WAVE Life Sciences (NASDAQ:WVE) Stock

WAVE Life Sciences

WAVE Life Sciences Ltd is a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines also known as oligonucleotides, targeting ribonucleic acid (RNA), to transform human health. RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Its toolkit of RNA-targeting modalities includes RNA editing, antisense silencing, and RNA interference, providing capabilities for designing and sustainably delivering candidates that optimally address disease biology. Its programs are for rare and prevalent diseases, including alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.

Wave Life Sciences Ltd. - Ordinary Shares

WAVE Life Sciences Ltd

HC Wainwright &amp; Co. analyst Andrew Fein reiterates WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) with a Buy and maintains $22 price target.

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HC Wainwright & Co. Reiterates Buy on WAVE Life Sciences, Maintains $22 Price Target

Wave Life Sciences Ltd.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) released data from the Phase 2 FORWARD-53 trial of WVE-N531, which is an exon-skipping oligonucleotide being investigated in boys with Duchenne muscular dystrophy (DMD) who are amenable <a target="_blank" href="https://www.benzinga.com/general/biotech" rel="noreferrer noopener">to exon 53 skipping</a>.
DMD is the most common hereditary neuromuscular disease. Mutations in the&nbsp;dystrophin&nbsp;gene lead to progressive muscle fiber <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/g44490973/wave-life-sciences-announces-positive-data-from-forward-53-clinical-trial-in-dmd-including-signifi" rel="noreferrer noopener">degeneration and weakness</a>.
The company on Wednesday said FORWARD-53 achieved all trial goals, demonstrating sustained exon skipping, muscle concentrations, and dystrophin restoration through 48 weeks and a 61-day tissue half-life that supports monthly dosing.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/10/41359843/wave-life-sciences-reveals-rna-editing-breakthrough-reports-first-ever-clinical-proof-of-mechanis" rel="noreferrer noopener">Wave Life Sciences Reveals RNA Editing Breakthrough, Reports First-Ever Clinical Proof-Of-Mechanism In Humans</a>
WVE-N531 continues to be safe and well-tolerated.
Additionally, the company said the data demonstrate substantial decreases in inflammation and necrosis, a statistically significant reversal of muscle fibrosis (28.6% reduction between weeks 24 and 48), and a transition from muscle regeneration to maturation.
A 50% decline in creatine kinase (CK) and decreases in IL-6 and MCP-1 were also observed.
Time-to-Rise (TTR) data demonstrate a statistically significant and clinically meaningful 3.8-second improvement versus natural history.
Additional functional benefits were observed on the North Star Ambulatory Assessment (NSAA) compared to natural history and in-hand grip strength compared to baseline.
On Wednesday, Wave also announced that it met with the U.S. Food and Drug Administration (FDA) on WVE-N531 to discuss its interim 24-week data and initial plans for the confirmatory trial.
Wave intends to file a New Drug Application in 2026 for accelerated approval of WVE-N531.
WVE-N531, as well as Wave&#8217;s programs for exons 52, 51, 45, and 44, collectively could address around 40% of the DMD population and represent over $2.4 billion in total market opportunity in the United States alone.
Wave expects to submit multiple clinical trial applications for other exon-skipping programs in 2026.
Price Action: WVE stock is up 14.9% at $10.85 at the last check on Wednesday.
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Wave Life Sciences Stock Jumps On Positive Data From Muscle Disorder Drug, Plans FDA Submission Next Year

WIIM

Wave Life Sciences shares are trading higher after the company announced its Phase 2 DMD trial results.

Wave Life Sciences Ltd.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, today announced positive data from the Phase 2 FORWARD-53 trial of WVE-N531, which is an exon skipping oligonucleotide being investigated in boys with Duchenne muscular dystrophy (DMD) who are amenable to exon 53 skipping. The analysis was conducted after 48 weeks of treatment with 10 mg/kg WVE-N531 dosed every two weeks (Q2W).
FORWARD-53 achieved all trial goals, demonstrating sustained and industry-leading exon skipping, muscle concentrations and dystrophin restoration through 48 weeks and a 61-day tissue half-life that supports monthly dosing. WVE-N531 continues to be safe and well-tolerated.
Additionally, the data demonstrate substantial decreases in inflammation and necrosis, a statistically significant reversal of muscle fibrosis (28.6% reduction between week 24 to 48; p&lt;0.01), and a transition from regeneration to maturation of muscle. A 50% decline (&lt;0.001) in creatine kinase (CK), as well as decreases in IL-6 and MCP-1, were also observed. Time-to-Rise (TTR) data demonstrate a statistically significant and clinically meaningful 3.8-second improvement versus natural history (p&lt;0.05), which is the largest effect observed relative to any approved dystrophin restoration therapy at 48 weeks. Additional functional benefits were observed on the North Star Ambulatory Assessment (NSAA) versus natural history, and in hand grip strength versus baseline.

Wave Life Sciences Reports Phase 2 DMD Trial Results With Dystrophin Restoration

Wave Life Sciences shares are trading higher after the company reported better-than-expected Q4 financial results.

WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) reported quarterly earnings of $0.17 per share which beat the analyst consensus estimate of $(0.19) by 189.47 percent. This is a 213.33 percent increase over losses of $(0.15) per share from the same period last year. The company reported quarterly sales of $83.70 million which beat the analyst consensus estimate of $28.04 million by 198.55 percent. This is a 188.06 percent increase over sales of $29.06 million the same period last year.

Earnings

Earnings Beats

WAVE Life Sciences Q4 2024 GAAP EPS $0.17 Beats $(0.19) Estimate, Sales $83.70M Beat $28.04M Estimate

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This article was generated by Benzinga's automated content engine and reviewed by an editor.

ACNT

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CGEN

CHPT

CPIX

CRCT

CRDO

CRWD

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CXDO

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EOLS

EOSE

ESPR

EVGO

FSTR

FTEK

GENI

GIFI

HGTY

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INFU

INGM

KIDS

MASS

MFIN

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OLPX

ONON

OOMA

OWLT

PLUG

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PSFE

RIGL

ROST

SCOR

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STEM

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Earnings Scheduled For March 4, 2025

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our <a href="https://www.benzinga.com/analyst-stock-ratings">analyst ratings page</a>.
<ul>
<li>Jefferies analyst Roger Song initiated coverage on Wave Life Sciences Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) with a Buy rating and announced a price target of $26. WAVE Life Sciences shares closed at $10.48 on Monday. <a href="https://www.benzinga.com/quote/WVE/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>TD Securities analyst Andrew Charles initiated coverage on Kura Sushi USA, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/KRUS#NASDAQ">KRUS</a>) with a Hold rating and announced a price target of $72. Kura Sushi USA shares closed at $64.71 on Monday. <a href="https://www.benzinga.com/quote/KRUS/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Leerink Partners analyst Joseph Schwartz initiated coverage on Maze Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MAZE#NASDAQ">MAZE</a>) with an Outperform rating and announced a price target of $28. Maze Therapeutics shares closed at $10.82 on Monday. <a href="https://www.benzinga.com/quote/MAZE/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>RBC Capital analyst Leonid Timashev initiated coverage on Insmed Incorporated (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INSM#NASDAQ">INSM</a>) with an Outperform rating and announced a price target of $100. Insmed shares closed at $80.03 on Monday. <a href="https://www.benzinga.com/quote/INSM/analyst-ratings">See how other analysts view this stock</a>.</li>
<li>Keybanc analyst Tim Rezvan initiated coverage on Infinity Natural Resources, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/INR#NYSE">INR</a>) with an Overweight rating and announced a price target of $26. Infinity shares closed at $19.13 on Monday. <a href="https://www.benzinga.com/quote/INR/analyst-ratings">See how other analysts view this stock.</a></li>
</ul>
Considering buying INSM stock? Here&#8217;s what analysts think: 
<figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" width="1024" height="583" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/25132813/image-204-1024x583.png" alt="" class="wp-image-798137" style="width:585px;height:auto" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/25132813/image-204-1024x583.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/25132813/image-204-300x171.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/25132813/image-204-768x437.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/25132813/image-204.png 1142w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>
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Initiation

Markets

Morgan Stanley Market Vectors Rupee/USD ETN

INSM

KRUS

MAZE

This Insmed Analyst Begins Coverage On A Bullish Note; Here Are Top 5 Initiations For Tuesday

Jefferies analyst Roger Song initiates coverage on WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) with a Buy rating and announces Price Target of $26.

Jefferies Initiates Coverage On WAVE Life Sciences with Buy Rating, Announces Price Target of $26

WVE-007 is a novel, long-acting GalNAc-siRNA targeting INHBE mRNA – a genetically validated target that provides a new approach for healthy, sustainable weight loss (fat loss with muscle preservation)
Proof-of-concept clinical data from INLIGHT are expected in 2025

Wave Life Sciences Initiates Phase 1 INLIGHT Clinical Trial Of WVE-007 In Obesity

Entering 2025 having demonstrated rapid translation of genetic insights to positive clinical data; advancing clinically validated and multi-modal pipeline with the potential to treat well over 100 million patients
CTAs submitted for Phase 1 INLIGHT clinical trial of WVE-007, a novel, long-acting, muscle-sparing GalNAc-siRNA approach for obesity targeting INHBE grounded in human genetics; proof-of-concept clinical data expected in 2025
Pioneering entirely new therapeutic field of RNA editing and building on positive WVE-006 proof-of mechanism clinical data; expect multidose AATD data, new preclinical data from hepatic and extra-hepatic RNA editing programs and candidate selections in 2025
Expect feedback from regulators and 48-week FORWARD-53 data for WVE-N531 in DMD in 1Q 2025; positive interim data demonstrated highly consistent dystrophin expression and best-in-class muscle delivery
Advancing WVE-003 – only allele-selective treatment for HD; planning underway for potentially registrational Phase 2/3 study with caudate atrophy as a primary endpoint and IND submission expected 2H 2025
Well-capitalized with expected runway into 2027

Guidance

Wave Life Sciences Announces 2025 Plans, Phase 1 INLIGHT Trial For Obesity Target WVE-007; RNA Editing Advancements With WVE-006; Regulatory Feedback And 48-Week Data For WVE-N531 In DMD Expected Q1 2025; Phase 2/3 Study For HD Treatment WVE-003 In Planning; Capital Runway To 2027

WVE-007 is a novel approach for treating obesity and is designed to silence INHBE to achieve healthy, sustainable weight loss through fat burning, muscle maintenance and the potential for once or twice-annual administration
WVE-007 is Wave's first siRNA program to enter clinical development and uses best-in-class oligonucleotide chemistry and GalNAc delivery
Wave expects to initiate the first-in-human study of WVE-007 in 1Q 2025
CAMBRIDGE, Mass., Dec. 23, 2024 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, today announced the submission of its first clinical trial application (CTA) for WVE-007 in obesity. WVE-007 is an investigational GalNAc-conjugated small interfering RNA (siRNA) designed to silence Inhibin&nbsp;βE (INHBE) gene expression, which would induce fat burning (lipolysis) to decrease body weight without impacting muscle mass. Wave expects CTA approval and initiation of the first-in-human study of WVE-007 in the first quarter of 2025.

Wave Life Sciences Announces Submission Of First Clinical Trial Application For WVE-007 In Obesity

Mizuho analyst Salim Syed maintains WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) with a Outperform and raises the price target from $19 to $22.

Mizuho Maintains Outperform on WAVE Life Sciences, Raises Price Target to $22

Truist Securities analyst Joon Lee maintains WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) with a Buy and raises the price target from $17 to $36.

Truist Securities Maintains Buy on WAVE Life Sciences, Raises Price Target to $36

WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) reported quarterly losses of $(0.47) per share which missed the analyst consensus estimate of $(0.28) by 67.86 percent.

Earnings Misses

WAVE Life Sciences Q3 2024 GAAP EPS $(0.47) Misses $(0.28) Estimate

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Avadel Pharmaceuticals plc - American Depositary Shares each representing one Ordinary Share

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The Beachbody Company, Inc. Class A Common Stock

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Earnings Scheduled For November 12, 2024

WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) is preparing to release its quarterly earnings on Tuesday, 2024-11-12. Here's a brief overview of what investors should keep in mind before the announcement.
Analysts expect WAVE Life Sciences to report an earnings per share (EPS) of $-0.29.
Anticipation surrounds WAVE Life Sciences's announcement, with investors hoping to hear about both surpassing estimates and receiving positive guidance for the next quarter.
New investors should understand that while earnings performance is important, market reactions are often driven by guidance.
<h3>Earnings History Snapshot</h3>
During the last quarter, the company reported an EPS missed by $0.04, leading to a 5.75% drop in the share price on the subsequent day.
Here's a look at WAVE Life Sciences's past performance and the resulting price change:

<table>
<thead>
<tr>
<th>Quarter</th>
<th>Q2 2024</th>
<th>Q1 2024</th>
<th>Q4 2023</th>
<th>Q3 2023</th>
</tr>
</thead>
<tbody>
<tr>
<td>EPS Estimate</td>
<td>-0.21</td>
<td>-0.21</td>
<td>-0.23</td>
<td>-0.18</td>
</tr>
<tr>
<td>EPS Actual</td>
<td>-0.25</td>
<td>-0.24</td>
<td>-0.15</td>
<td>0.07</td>
</tr>
<tr>
<td>Price Change %</td>
<td>-6.0%</td>
<td>-2.0%</td>
<td>8.0%</td>
<td>1.0%</td>
</tr>
</tbody>
</table>

<img src="https://www.benzinga.com/files/images/story/2024/1731333748_0.png" alt="eps graph" />
<h3>Tracking WAVE Life Sciences's Stock Performance</h3>
Shares of WAVE Life Sciences were trading at $16.44 as of November 08. Over the last 52-week period, shares are up 202.21%. Given that these returns are generally positive, long-term shareholders are likely bullish going into this earnings release. 
<a href="https://www.benzinga.com/quote/WVE/earnings">To track all earnings releases for WAVE Life Sciences visit their earnings calendar on our site.</a>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

What's Next: WAVE Life Sciences's Earnings Preview

B. Riley Securities analyst Madison El-Saadi maintains WAVE Life Sciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WVE#NASDAQ">WVE</a>) with a Buy and raises the price target from $19 to $22.

B. Riley Securities Maintains Buy on WAVE Life Sciences, Raises Price Target to $22

Press Releases

Wave Life Sciences Reports Third Quarter 2024 Financial Results and Provides Business Update

Wave Life Sciences to Present at Jefferies London Healthcare Conference

Wave Life Sciences to Present at Upcoming Investor Conferences

Wave Life Sciences to Present at 43rd Annual J.P. Morgan Healthcare Conference

Wave Life Sciences Announces Submission of First Clinical Trial Application for WVE-007 (siRNA Targeting INHBE) in Obesity

Wave Life Sciences Highlights Strategic Priorities and Expected 2025 Milestones Ahead of J.P. Morgan Presentation

Wave Life Sciences Announces Initiation of Phase 1 INLIGHT Clinical Trial of WVE-007 in Obesity

Wave Life Sciences Fourth Quarter and Full Year 2024 Financial Results Scheduled for March 4, 2025

Wave Life Sciences Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update

Wave Life Sciences Announces Positive Data from FORWARD-53 Clinical Trial in DMD Including Significant Functional Benefit and Reversal of Muscle Damage after 48 Weeks of Dosing with WVE-N531

Alumis

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