Dernières nouvelles pour Pfizer (NYSE:PFE) Stock

Pfizer

Pfizer is one of the world's largest pharmaceutical firms, with annual sales close to $50 billion (excluding covid-19-related product sales). While it historically sold many types of healthcare products and chemicals, now prescription drugs and vaccines account for the majority of sales. Top sellers include pneumococcal vaccine Prevnar 13, cancer drug Ibrance, and cardiovascular treatment Eliquis. Pfizer sells these products globally, with international sales representing close to 50% of total sales. Within international sales, emerging markets are a major contributor.

Pfizer Inc

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Starboard Value's Latest 13F Filing Reveals New Stakes In Kenvue By 21.91M Shares, Pfizer By 15.37M Shares, Healthcare Realty Trust By 20.18M Shares, And Riot Platforms By 12.70M Shares.

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Trump Order Halts Funding For School Covid Vaccine Mandates

On Thursday, Pfizer Inc.&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>)&nbsp;revealed results from the Phase 3 TALAPRO-2 study of Talzenna&nbsp;(talazoparib) in combination <a target="_blank" href="https://www.benzinga.com/pressreleases/25/02/b43696191/pfizers-talzenna-in-combination-with-xtandi-improves-survival-outcomes-in-metastatic-castration-re" rel="noreferrer noopener">with Xtandi&nbsp;(enzalutamide)</a>.
The trial demonstrated a statistically significant and clinically meaningful improvement in overall survival (OS) compared to placebo plus Xtandi in patients with metastatic castration-resistant prostate cancer (mCRPC), with or without homologous recombination repair (HRR) gene mutations.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/25/02/43636349/pfizer-astellas-tout-encouraging-data-from-keytruda-combo-regime-in-urothelial-cancer-showing-49-reduction-in-death-risk-vs-chemo" rel="noreferrer noopener">Pfizer/Astellas Tout Encouraging Data From Keytruda Combo Regime In Urothelial Cancer Showing 49% Reduction In Death Risk Vs. Chemo</a>
The TALAPRO-2 study evaluated two sets of patients, unselected (cohort 1) and selected for HRR gene-mutations (cohort 2).
Overall survival was a prespecified, alpha-protected key secondary endpoint.
After more than four years of median follow-up (52.5 months), the median OS in cohort 1 was 45.8 months with Talzenna in combination with Xtandi and 37.0 months with Xtandi and placebo, representing a 20% reduction in the risk of death, representing a nearly 9-month gain in median OS versus standard of care Xtandi.
In Cohort 2, a statistically significant and clinically meaningful improvement in OS was observed in patients with HRR-mutated mCRPC.
At a median follow-up of 44.2 months, the median OS was 45.1 months with Talzenna in combination with Xtandi and 31.1 months with Xtandi and placebo, a 38% reduction in the risk of death, representing a 14-month gain in median OS versus standard of care Xtandi in a patient population with a historically poor prognosis.
The OS improvement in the HRR-mutated population was observed in patients with BRCA and non-BRCA gene alterations.
At the time of the final analysis, updated radiographic progression-free survival (rPFS) and other secondary efficacy endpoints demonstrated maintained clinical benefit in both cohorts and were consistent with the primary analyses&nbsp;<a target="_blank" href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.pfizer.com%2Fnews%2Fpress-release%2Fpress-release-detail%2Fpfizer-announces-positive-talzennar-and-xtandir-combination&amp;esheet=54204140&amp;newsitemid=20250213091824&amp;lan=en-US&amp;anchor=previously+reported&amp;index=3&amp;md5=ea73e565cd9cb9796d6e5d091df9343c" rel="noreferrer noopener">previously reported</a>&nbsp;and published in&nbsp;The Lancet&nbsp;and&nbsp;Nature Medicine.
Price Action: Pfizer stock is up 0.04% at $25.65 at last check Friday.
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<li><a href="https://www.benzinga.com/government/regulations/25/02/43730124/apple-focuses-on-alibaba-baidu-partnership-in-race-to-bring-ai-features-to-china-by-mid-2025" target="_blank" rel="noreferrer noopener">Apple Focuses On Alibaba, Baidu Partnership In Race To Bring AI Features To China by Mid-2025</a></li>
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Image: Shutterstock

Large Cap

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Pfizer's Talzenna/Xtandi Combo Improves Survival Outcomes In Metastatic Castration-Resistant Prostate Cancer

Politics

Robert F. Kennedy Jr. Sworn In as HHS Secretary

The U.S. Senate voted on Thursday to confirm President Donald Trump's nomination of Robert F. Kennedy Jr. to lead the Department of <a href="https://www.benzinga.com/25/01/43306674/trumps-hhs-pick-robert-kennedy-jr-begins-senate-confirmation-hearings">Health and Human Services.&nbsp;</a>
The Details: The Senate voted 52 to 48 to confirm Kennedy as health secretary, with Sen. Mitch McConnell as the only Republican who voted "no." All Democrats voted against the nomination. 
As secretary of health, Kennedy will oversee several critical health agencies including the Food and Drug Administration, Centers for Disease Control and Prevention and the Centers for Medicare and Medicaid Services.&nbsp;
Kennedy takes the helm of the nation's health systems as health care costs are soaring and bird flu is spreading through wild birds and poultry farms, with the potential for a pandemic if the virus evolves to transmit between humans. 
Read More: <a href="https://www.benzinga.com/25/02/43663963/record-high-egg-prices-drive-inflation-higher-in-january">Record-High Egg Prices Drive Inflation Higher In January</a>
What To Watch: During his Senate <a href="https://www.benzinga.com/general/health-care/25/01/43321236/rfk-jr-and-big-pharma-stocks-to-watch-as-health-secretary-hopeful-answers-pointed-questions-on-drugs-insurance-trump-exec-orders">hearings in January</a>, Kennedy called out &#8220;rapacious behavior by insurance companies" and suggested he would support efforts to crack down on abusive tactics like denying care and overcharging the government.
Some insurers tied to Medicaid and Medicare are UnitedHealth Group Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UNH#NYSE">UNH</a>), the largest Medicare Advantage insurer in the U.S., and Elevance Health, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ELV#NYSE">ELV</a>), one of the largest Medicaid managed care organizations.&nbsp;
Kennedy has been an outspoken skeptic on vaccines for decades and pharmaceutical stocks could be affected by potential policy changes under his leadership. Some of the largest pharmaceutical companies that produce vaccines are Moderna, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MRNA#NASDAQ">MRNA</a>), Merck &amp; Company, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MRK#NYSE">MRK</a>) and Pfizer, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>)&nbsp;
While campaigning for president in 2024, Kennedy <a href="https://x.com/RobertKennedyJr/status/1804923391595696553">wrote a post</a> on social media doubting the safety and efficacy of bird flu vaccines in particular.&nbsp;
&#8220;There is no evidence these vaccines will work, and they appear to be dangerous,&#8221; Kennedy wrote.&nbsp;
He also attempted to push a conspiracy theory that stated deadly bird flu strains were being engineered in government labs in order to create a market for pharmaceutical companies to profit from vaccines. 
&#8220;We already know our public health agencies are out of control.&nbsp; We have to stop the runaway gain-of-function experiments and the highly lucrative pandemic vaccine experiments right now,&#8221; he wrote.&nbsp;
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Image: Shutterstock.

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RFK Jr. Has Been Confirmed As The Next Health And Human Services Secretary

<ul>
<li>TALZENNA + XTANDI is the first PARP inhibitor plus ARPI combination to demonstrate statistically significant and clinically meaningful improvement in overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) regardless of HRR mutation status</li>
<li>TALZENNA + XTANDI improved median OS by almost 9 months in unselected patients (Cohort 1) and by 14 months in patients selected for HRR mutations (Cohort 2) versus standard of care XTANDI</li>
</ul>
<a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.pfizer.com%2F&amp;esheet=54204140&amp;newsitemid=20250213091824&amp;lan=en-US&amp;anchor=Pfizer+Inc.&amp;index=1&amp;md5=d505a66876c5e067f1ef8d767e8cc803">Pfizer Inc.</a> (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) today announced positive results from the Phase 3 TALAPRO-2 study of TALZENNA&#xAE; (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI&#xAE; (enzalutamide), an androgen receptor pathway inhibitor (ARPI), demonstrating a statistically significant and clinically meaningful improvement in overall survival (OS) compared to placebo plus XTANDI in patients with metastatic castration-resistant prostate cancer (mCRPC), with or without homologous recombination repair (HRR) gene mutations. The TALAPRO-2 results will be presented at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium in San Francisco and featured in the <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.asco.org%2Fabout-asco%2Fpress-center%2Fnews-releases%2Fadvances-prostate-cancer-treatment-community-based-screening&amp;esheet=54204140&amp;newsitemid=20250213091824&amp;lan=en-US&amp;anchor=ASCO+GU+official+Press+Program&amp;index=2&amp;md5=3756fc2af6e212e90acb4ac0baf9aad6">ASCO GU official Press Program</a>.
The TALAPRO-2 study evaluated two sets of patients, unselected (cohort 1) and selected for HRR gene-mutations (cohort 2). Overall survival was a prespecified, alpha-protected key secondary endpoint. After more than four years of median follow-up (52.5 months), the median OS in cohort 1 was 45.8 months with TALZENNA in combination with XTANDI, and 37.0 months with XTANDI and placebo (Hazard Ratio [HR] of 0.80; 95% Confidence Interval [CI], 0.66-0.96; p=0.015), representing a 20% reduction in the risk of death. This represents a nearly 9-month gain in median OS versus standard of care XTANDI. Data from cohort 1 will be presented today at ASCO GU in an oral presentation (Abstract LBA18) by Dr. Neeraj Agarwal, global lead investigator for TALAPRO-2.
In Cohort 2, a statistically significant and clinically meaningful improvement in OS was observed in patients with HRR-mutated mCRPC. At a median follow-up of 44.2 months, the median OS was 45.1 months with TALZENNA in combination with XTANDI, and 31.1 months with XTANDI and placebo (HR of 0.62; 95% CI, 0.48-0.81; p=0.0005), a 38% reduction in the risk of death. This result represents a 14-month gain in median OS versus standard of care XTANDI in a patient population with a historically poor prognosis. The OS improvement in the HRR-mutated population was observed in patients in both BRCA and non-BRCA gene alterations. Dr. Karim Fizazi, Institut Gustave Roussy, University of Paris-Saclay will share data from Cohort 2 at ASCO GU today (Abstract LBA141).

Pfizer Announces Phase 3 TALAPRO-2 Study Results: TALZENNA + XTANDI Shows Significant OS Improvement In mCRPC Patients; 9-Month OS Gain In Unselected Paitents, 14-Month In Paitents Selected For HRR Mutations, Secondary Endpoint Met; To Be Presented at ASCO GU Symposium

ViiV Healthcare, the global specialist HIV company majority owned by GlaxoSmithKline plc (GSK), with Pfizer Inc. and Shionogi as shareholders, is pleased to announce it has successfully completed negotiations with the pan-Canadian Pharmaceutical Alliance (pCPA) for&nbsp;APRETUDE (cabotegravir tablets and extended release injectable suspension) for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection in at-risk individuals who are HIV-1 negative.1
ViiV Healthcare is committed to ensuring timely public access for APRETUDE to help reduce the risk of sexually acquired HIV-1 infection and make progress towards global targets of ending HIV by 2030, which Canada endorsed.2,3&nbsp;ViiV Healthcare recognizes the pCPA's efforts and shared commitment to achieving this goal. This milestone underscores the need to expedite public reimbursement and as such, ViiV Healthcare looks forward to working with provincial and territorial governments and other stakeholders to make APRETUDE available through public drug plans.
APRETUDE is the first and only long-acting injectable approved in Canada and is indicated for at-risk adults and adolescents aged 12 years and older and weighing at least 35 kg for PrEP to reduce the risk of sexually acquired HIV-1 infection. APRETUDE for PrEP has demonstrated superior efficacy to daily oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF tablets) in reducing the risk of HIV acquisition in two clinical trials, giving Canadians more options for PrEP.1&nbsp;

ViiV Healthcare And The Pan-Canadian Pharmaceutical Alliance Finalize Negotiations For APRETUDE For HIV-1 Pre-Exposure Prophylaxis

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders often look for circumstances when the market estimation of an option diverges away from its normal worth. Abnormal amounts of trading activity could push option prices to hyperbolic or underperforming levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>PFE</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>03/21/25</td>
<td>$27.50</td>
<td>$48.6K</td>
<td>44.4K</td>
<td>7.2K</td>
</tr>
<tr>
<td>ACAD</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>06/20/25</td>
<td>$20.00</td>
<td>$157.6K</td>
<td>109</td>
<td>1.9K</td>
</tr>
<tr>
<td>TEM</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>04/17/25</td>
<td>$65.00</td>
<td>$28.5K</td>
<td>2.8K</td>
<td>840</td>
</tr>
<tr>
<td>ZTS</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>02/21/25</td>
<td>$180.00</td>
<td>$43.0K</td>
<td>1.4K</td>
<td>316</td>
</tr>
<tr>
<td>EBS</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>09/19/25</td>
<td>$11.00</td>
<td>$43.8K</td>
<td>4</td>
<td>200</td>
</tr>
<tr>
<td>BMRN</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>02/21/25</td>
<td>$65.00</td>
<td>$29.2K</td>
<td>1.3K</td>
<td>159</td>
</tr>
<tr>
<td>HUM</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>04/17/25</td>
<td>$245.00</td>
<td>$191.7K</td>
<td>141</td>
<td>125</td>
</tr>
<tr>
<td>HIMS</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>02/21/25</td>
<td>$37.00</td>
<td>$69.7K</td>
<td>1.0K</td>
<td>87</td>
</tr>
<tr>
<td>EXEL</td>
<td>CALL</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>02/21/25</td>
<td>$17.00</td>
<td>$29.5K</td>
<td>98</td>
<td>50</td>
</tr>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>02/21/25</td>
<td>$800.00</td>
<td>$37.5K</td>
<td>843</td>
<td>31</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These bullet-by-bullet explanations have been constructed using the accompanying table. 
• For PFE (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>), we notice a call option sweep that happens to be bullish, expiring in 37 day(s) on March 21, 2025. This event was a transfer of 2561 contract(s) at a $27.50 strike. This particular call needed to be split into 21 different trades to become filled. The total cost received by the writing party (or parties) was $48.6K, with a price of $19.0 per contract. There were 44426 open contracts at this strike prior to today, and today 7236 contract(s) were bought and sold. 
• For ACAD (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ACAD#NASDAQ">ACAD</a>), we notice a call option sweep that happens to be bullish, expiring in 128 day(s) on June 20, 2025. This event was a transfer of 901 contract(s) at a $20.00 strike. This particular call needed to be split into 8 different trades to become filled. The total cost received by the writing party (or parties) was $157.6K, with a price of $175.0 per contract. There were 109 open contracts at this strike prior to today, and today 1920 contract(s) were bought and sold. 
• For TEM (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TEM#NASDAQ">TEM</a>), we notice a call option trade that happens to be bearish, expiring in 64 day(s) on April 17, 2025. This event was a transfer of 20 contract(s) at a $65.00 strike. The total cost received by the writing party (or parties) was $28.5K, with a price of $1425.0 per contract. There were 2849 open contracts at this strike prior to today, and today 840 contract(s) were bought and sold. 
• For ZTS (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ZTS#NYSE">ZTS</a>), we notice a call option sweep that happens to be bearish, expiring in 9 day(s) on February 21, 2025. This event was a transfer of 200 contract(s) at a $180.00 strike. This particular call needed to be split into 6 different trades to become filled. The total cost received by the writing party (or parties) was $43.0K, with a price of $215.0 per contract. There were 1473 open contracts at this strike prior to today, and today 316 contract(s) were bought and sold. 
• Regarding EBS (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EBS#NYSE">EBS</a>), we observe a call option trade with bearish sentiment. It expires in 219 day(s) on September 19, 2025. Parties traded 200 contract(s) at a $11.00 strike. The total cost received by the writing party (or parties) was $43.8K, with a price of $219.0 per contract. There were 4 open contracts at this strike prior to today, and today 200 contract(s) were bought and sold. 
• Regarding BMRN (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BMRN#NASDAQ">BMRN</a>), we observe a call option trade with bullish sentiment. It expires in 9 day(s) on February 21, 2025. Parties traded 150 contract(s) at a $65.00 strike. The total cost received by the writing party (or parties) was $29.2K, with a price of $195.0 per contract. There were 1333 open contracts at this strike prior to today, and today 159 contract(s) were bought and sold. 
• For HUM (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HUM#NYSE">HUM</a>), we notice a call option trade that happens to be bearish, expiring in 64 day(s) on April 17, 2025. This event was a transfer of 65 contract(s) at a $245.00 strike. The total cost received by the writing party (or parties) was $191.7K, with a price of $2950.0 per contract. There were 141 open contracts at this strike prior to today, and today 125 contract(s) were bought and sold. 
• For HIMS (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIMS#NYSE">HIMS</a>), we notice a call option trade that happens to be bullish, expiring in 9 day(s) on February 21, 2025. This event was a transfer of 81 contract(s) at a $37.00 strike. The total cost received by the writing party (or parties) was $69.7K, with a price of $861.0 per contract. There were 1026 open contracts at this strike prior to today, and today 87 contract(s) were bought and sold. 
• For EXEL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EXEL#NASDAQ">EXEL</a>), we notice a call option trade that happens to be neutral, expiring in 9 day(s) on February 21, 2025. This event was a transfer of 18 contract(s) at a $17.00 strike. The total cost received by the writing party (or parties) was $29.5K, with a price of $1640.0 per contract. There were 98 open contracts at this strike prior to today, and today 50 contract(s) were bought and sold. 
• Regarding LLY (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), we observe a call option trade with bearish sentiment. It expires in 9 day(s) on February 21, 2025. Parties traded 5 contract(s) at a $800.00 strike. The total cost received by the writing party (or parties) was $37.5K, with a price of $7518.0 per contract. There were 843 open contracts at this strike prior to today, and today 31 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more about unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Options

ACAD

BMRN

EXEL

Hims & Hers Health, Inc. Class A Common Stock

HIMS

10 Health Care Stocks With Whale Alerts In Today's Session

Macro Economic Events

Global

Economics

STLA

TSLA

House Speaker Johnson Says He Believes The White House Is Considering Exemptions To Reciprocal Tariffs Including Autos And Pharmaceuticals

<a href="https://www.businesswire.com/news/home/20250207460554/en/U.S.-FDA-Approves-Pfizer%E2%80%99s-ADCETRIS%C2%AE-Combination-Regimen-for-the-treatment-of-RelapsedRefractory-Diffuse-Large-B-Cell-Lymphoma">https://www.businesswire.com/news/home/20250207460554/en/U.S.-FDA-Approves-Pfizer%E2%80%99s-ADCETRIS%C2%AE-Combination-Regimen-for-the-treatment-of-RelapsedRefractory-Diffuse-Large-B-Cell-Lymphoma</a>
<ul>
<li>Approval is based on positive data from the Phase 3 ECHELON-3 trial, which demonstrated ADCETRIS regimen reduced the risk of death by 37%, a statistically significant, clinically meaningful improvement in overall survival (OS), compared to lenalidomide and rituximab plus placebo</li>
<li>ECHELON-3 is the first Phase 3 trial to demonstrate OS advantage over lenalidomide and rituximab plus placebo for patients with at least 2 prior lines of therapy with R/R diffuse large B-cell lymphoma (DLBCL)</li>
<li>Milestone represents the eighth FDA-approved indication for ADCETRIS, reinforcing its use as a standard of care for certain lymphomas</li>
</ul>

U.S. FDA Approves Pfizer's ADCETRIS Combination Regimen For The Treatment Of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-brentuximab-vedotin-lenalidomide-and-rituximab-relapsed-or-refractory-large-b-cell#:~:text=On%20February%2011%2C%202025%2C%20the,%2Dcell%20lymphoma%20(DLBCL)%20not

Reported Feb 11, 2025 FDA Approves Brentuximab Vedotin With Lenalidomide And Rituximab For Relapsed Or Refractory Large B-Cell Lymphoma

Whales with a lot of money to spend have taken a noticeably bullish stance on Pfizer.
Looking at options history for Pfizer (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) we detected 15 trades.
If we consider the specifics of each trade, it is accurate to state that 53% of the investors opened trades with bullish expectations and 26% with bearish.
From the overall spotted trades, 3 are puts, for a total amount of $345,963 and 12, calls, for a total amount of $1,524,951.
<h3>Expected Price Movements</h3>
Taking into account the Volume and Open Interest on these contracts, it appears that whales have been targeting a price range from $20.0 to $30.0 for Pfizer over the last 3 months. 
<h3>Volume &amp; Open Interest Development</h3>
Looking at the volume and open interest is a powerful move while trading options. This data can help you track the liquidity and interest for Pfizer's options for a given strike price. Below, we can observe the evolution of the volume and open interest of calls and puts, respectively, for all of Pfizer's whale trades within a strike price range from $20.0 to $30.0 in the last 30 days. 
<h3>Pfizer Call and Put Volume: 30-Day Overview</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1739304945_0.png" alt="Options Call Chart" />
<h3>Noteworthy Options Activity:</h3>

<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Ask</th>
<th>Bid</th>
<th>Price</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>PFE</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>02/21/25</td>
<td>$0.98</td>
<td>$0.93</td>
<td>$0.98</td>
<td>$25.00</td>
<td>$245.0K</td>
<td>5.8K</td>
<td>2.5K</td>
</tr>
<tr>
<td>PFE</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>02/21/25</td>
<td>$0.98</td>
<td>$0.98</td>
<td>$0.98</td>
<td>$25.00</td>
<td>$232.7K</td>
<td>5.8K</td>
<td>2.4K</td>
</tr>
<tr>
<td>PFE</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>08/15/25</td>
<td>$1.6</td>
<td>$1.53</td>
<td>$1.53</td>
<td>$25.00</td>
<td>$229.5K</td>
<td>4.4K</td>
<td>13</td>
</tr>
<tr>
<td>PFE</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>02/21/25</td>
<td>$1.0</td>
<td>$0.85</td>
<td>$1.0</td>
<td>$25.00</td>
<td>$217.7K</td>
<td>5.8K</td>
<td>9.6K</td>
</tr>
<tr>
<td>PFE</td>
<td>CALL</td>
<td>SWEEP</td>
<td>NEUTRAL</td>
<td>09/19/25</td>
<td>$3.55</td>
<td>$3.5</td>
<td>$3.5</td>
<td>$23.00</td>
<td>$175.5K</td>
<td>680</td>
<td>500</td>
</tr>
</tbody>
</table>

<h3>About Pfizer</h3>
Pfizer is one of the world's largest pharmaceutical firms, with annual sales close to $50 billion (excluding covid-19-related product sales). While it historically sold many types of healthcare products and chemicals, now prescription drugs and vaccines account for the majority of sales. Top sellers include pneumococcal vaccine Prevnar 13, cancer drug Ibrance, and cardiovascular treatment Eliquis. Pfizer sells these products globally, with international sales representing close to 50% of total sales. Within international sales, emerging markets are a major contributor.
In light of the recent options history for Pfizer, it's now appropriate to focus on the company itself. We aim to explore its current performance.
<h3>Current Position of Pfizer</h3>
<ul>
<li>Currently trading with a volume of 22,984,668, the PFE's price is down by -1.26%, now at $25.55. </li>
<li>RSI readings suggest the stock is currently is currently neutral between overbought and oversold.</li>
<li>Anticipated earnings release is in 78 days.</li>
</ul>
<h3>What The Experts Say On Pfizer</h3>
In the last month, 2 experts released ratings on this stock with an average target price of $31.0.
Unusual Options Activity Detected: Smart Money on the Move
Benzinga Edge's Unusual Options board spots potential market movers before they happen. See what positions big money is taking on your favorite stocks. <a href="https://www.benzinga.com/premium/ideas/benzinga-edge-checkout/?t=Be8be9arja3be22bz20&amp;utm_source=benzinga-insights">Click here for access</a>. 
&#x2A; An analyst from Guggenheim downgraded its action to Buy with a price target of $33. 
&#x2A; Consistent in their evaluation, an analyst from Citigroup keeps a Neutral rating on Pfizer with a target price of $29. 
Options are a riskier asset compared to just trading the stock, but they have higher profit potential. Serious options traders manage this risk by educating themselves daily, scaling in and out of trades, following more than one indicator, and following the markets closely.
If you want to stay updated on the latest options trades for Pfizer, <a href="https://benzinga.grsm.io/register174">Benzinga Pro</a> gives you real-time options trades alerts.

Markets

Pfizer's Options Frenzy: What You Need to Know

On Monday, Pfizer Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>)&nbsp;and Astellas Pharma Inc. (OTC:<a class="ticker" href="https://www.benzinga.com/stock/ALPMF#OTC">ALPMF</a>) (OTC:<a class="ticker" href="https://www.benzinga.com/stock/ALPMY#OTC">ALPMY</a>) released additional follow-up results from the Phase 3 EV-302 trial (also known as KEYNOTE-A39) of Padcev&nbsp;(enfortumab vedotin) plus Keytruda (pembrolizumab) in patients with previously untreated locally advanced or metastatic <a target="_blank" href="https://www.benzinga.com/pressreleases/25/02/b43610057/pfizer-and-astellas-padcev-enfortumab-vedotin-ejfv-plus-keytruda-pembrolizumab-shows-long-term-eff" rel="noreferrer noopener">urothelial cancer (la/mUC)</a>.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/25/02/43463168/pfizer-q4-earnings-revenue-and-eps-beat-seagen-and-covid-19-products-show-strength-issues-strong-fy25-outlook" rel="noreferrer noopener">Pfizer Q4 Earnings: Revenue And EPS Beat, Seagen And COVID-19 Products Show Strength, Issues Strong FY25 Outlook</a>
The results showed a sustained overall survival (OS) and progression-free survival (PFS) benefit consistent with the findings of the primary analysis after an additional 12 months of follow-up (median follow-up of 29.1 months).
<ul>
<li>Results showed enfortumab vedotin plus pembrolizumab reduced the risk of death by 49% versus chemotherapy.</li>
<li>The median OS was 33.8 months for the combination versus 15.9 months for chemotherapy.</li>
<li>The OS benefit was observed in all prespecified subgroups, including cisplatin eligible and ineligible subgroups.</li>
<li>Enfortumab vedotin plus pembrolizumab also reduced the risk of disease progression or death by 52% versus chemotherapy.</li>
<li>The median PFS was 12.5 months for the combination versus 6.3 months for chemotherapy.</li>
<li>The safety profile was consistent with previous findings and no new safety concerns were identified.</li>
</ul>
In addition to longer follow-up data, an exploratory analysis evaluating treatment outcomes and safety profile in patients with confirmed complete response (cCR) will also be presented.
<ul>
<li>Among patients evaluable for response, a confirmed objective response rate (cORR) was 67.5% for enfortumab vedotin plus pembrolizumab compared to 44.2% for chemotherapy.</li>
<li>Median duration of response (DOR) was 23.3 months for the combination and 7.0 months for chemotherapy.</li>
<li>A cCR was achieved in 30.4% of patients treated with enfortumab vedotin plus pembrolizumab and 14.5% of patients treated with chemotherapy.</li>
<li>The median duration of cCR was not reached for the combination and 15.2 months for chemotherapy.</li>
<li>In patients with cCR, grade ≥3 treatment-related adverse events occurred in 61.7% of patients in the enfortumab vedotin plus pembrolizumab arm compared to 71.9% in the chemotherapy arm. There were no treatment-related deaths in the cCR subgroup.</li>
</ul>
Price Action: PFE stock is down 1.29% at $25.54 at the last check on Tuesday.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/news/earnings/25/02/43629316/marriott-tops-q4-estimates-as-2025-outlook-pressures-stock" target="_blank" rel="noreferrer noopener">Marriott Tops Q4 Estimates As 2025 Outlook Pressures Stock</a></li>
</ul>
Image via Shutterstock

ALPMF

ALPMY

Pfizer/Astellas Tout Encouraging Data From Keytruda Combo Regime In Urothelial Cancer Showing 49% Reduction In Death Risk Vs. Chemo

The results showed a sustained overall survival (OS) and progression-free survival (PFS) benefit consistent with the findings of the primary analysis after an additional 12 months of follow-up (median follow-up of 29.1 months). These data will be presented during a rapid oral session (Abstract 664) at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) 2025 in San Francisco, CA, on February 14 at 4:10pm PT.

Pfizer, Astellas Announce Additional Follow-up Results From Phase 3 EV-302 Clinical Trial; Report Enfortumab Vedotin Plus Pembrolizumab Continues To Demonstrate Superior Efficacy Versus Chemotherapy

Super Bowl LIX aired on Sunday, Feb. 9, 2025 and the Philadelphia Eagles defeated the Kansas City Chiefs 40-22, ending the Chiefs' attempt to be the first three-peat <a href="https://www.benzinga.com/general/sports/25/02/43583513/eagles-fly-over-chiefs-40-22-as-super-bowl-lix-tests-potential-137-million-viewership-for-fox">Super Bowl winners.</a>
The game also featured dozens of commercials advertising products and showcasing new movies and television shows. They also featured many celebrity cameos.
What Happened: Super Bowl LIX commercials were <a href="https://www.benzinga.com/general/sports/25/02/43560232/super-bowl-lix-commercials-ai-celebs-muppets-warren-buffett-linked-brand-take-the-spotlight">priced between $7 million and $8 million</a> for a 30-second slot by Fox Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/FOX#NASDAQ">FOX</a>)(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/FOXA#NASDAQ">FOXA</a>), which had the media rights to the game.
Fox was able to secure $8 million or more for some last-second advertising inventory ahead of Sunday's game.
This author tracked all the commercials, from the singing of the National Anthem to the final round of ads after the Eagles won the Super Bowl. View the 2024 and 2023 Super Bowl commercials <a href="https://www.benzinga.com/general/sports/24/02/37076429/super-bowl-commercials-2024-complete-list-of-super-bowl-lviii-ads-and-companies-behind-them">here </a>and <a href="https://www.benzinga.com/general/entertainment/23/02/30883140/super-bowl-commercials-2023-the-complete-list-of-super-bowl-lvii-ads-and-the-companies-behi">here</a>. 
The tweet below shows the Super Bowl LIX commercial tracking in real time during the big game.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Super Bowl LIX Commercial Thread. Feel free to retweet. After National Anthem: Misson: Impossible The Final Reckoning Trailer <a href="https://twitter.com/search?q=%24PARA&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$PARA</a> Sketches <a href="https://twitter.com/search?q=%24SKX&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$SKX</a> TurboTax <a href="https://twitter.com/search?q=%24INTU&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$INTU</a> NASCAR on Fox <a href="https://twitter.com/search?q=%24FOX&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$FOX</a> After Con Toss: Lilo &amp; Stitch Live Action Spot <a href="https://twitter.com/search?q=%24DIS&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$DIS</a> YouTubeTV <a href="https://twitter.com/search?q=%24GOOG&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$GOOG</a>
&mdash; Chris Katje (@chriskatje) <a href="https://twitter.com/chriskatje/status/1888740049883173010?ref_src=twsrc%5Etfw">February 10, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
Here&#8217;s a list of the Super Bowl LIX commercials and the companies behind them.
After National Anthem:
<ul>
<li>"Mission: Impossible – The Final Reckoning" Trailer, Paramount (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PARA#NASDAQ">PARA</a>)(NASDA:PARAA)</li>
<li>Skechers (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SKX#NYSE">SKX</a>)</li>
<li>TurboTax, brand of Intuit Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INTU#NASDAQ">INTU</a>)</li>
<li>NASCAR on Fox</li>
</ul>
After Coin Toss:
<ul>
<li>Lilo &amp; Stitch live action movie teaser for Disney (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DIS#NYSE">DIS</a>)</li>
<li>YouTube TV, brand of Alphabet Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GOOG#NASDAQ">GOOG</a>)(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GOOGL#NASDAQ">GOOGL</a>)</li>
</ul>
After Kickoff, During First Quarter:
<ul>
<li>Dunkin'</li>
<li>"How to Train Your Dragon" live action movie trailer, Comcast (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CMCSA#NASDAQ">CMCSA</a>)</li>
<li>Pfizer Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>)</li>
<li>"Thunderbolts" trailer, Marvel film from Disney</li>
<li>MSC Cruises</li>
<li>Little Caesars</li>
<li>Fox News</li>
<li>T-Mobile (NASDA:TMUS) with Starlink</li>
<li>Homes.com, brand of CoStar Group (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CSGP#NASDAQ">CSGP</a>)</li>
<li>Meta Platforms (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/META#NASDAQ">META</a>) with Ray-Ban</li>
<li>IndyCar racing on Fox</li>
<li>Doritos, brand of PepsiCo (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PEP#NASDAQ">PEP</a>)</li>
<li>Cirkul</li>
<li>Michelob Ultra, brand of Anheuser-Busch InBev (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BUD#NYSE">BUD</a>)</li>
</ul>
After End of First Quarter, During Second Quarter:
<ul>
<li>Disney+ and Hulu streaming platforms</li>
<li>Ritz, brand of Mondelez International (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MDLZ#NASDAQ">MDLZ</a>)</li>
<li>Red Bull</li>
<li>Squarespace</li>
<li>"The Floor" on Fox</li>
<li>Local Ad</li>
<li>Mountain Dew Baja Blast, brand of PepsiCo</li>
<li>Instacart, brand of Maplebear (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CART#NASDAQ">CART</a>)</li>
<li>Coors Light, brand of Molson Coors Beverage (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TAP#NYSE">TAP</a>)</li>
<li>Stand Up to Hate</li>
<li>FanDuel Kick of Destiny challenge, brand of Flutter Entertainment (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/FLUT#NYSE">FLUT</a>)</li>
<li>"Extracted" on Fox</li>
<li>Uber Eats, brand of Uber Technologies (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UBER#NYSE">UBER</a>)</li>
<li>WeatherTech</li>
<li>TurboTax, brand of Intuit</li>
<li>NASCAR on Fox</li>
<li>Google Pixel phone with Gemini AI</li>
<li>UFL on Fox</li>
<li>Rocket Companies (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/RKT#NYSE">RKT</a>)</li>
<li>He Gets Us</li>
<li>Liquid Death</li>
<li>HexClad</li>
<li>Duracell, brand of Berkshire Hathaway (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BRK#NYSE">BRK</a>)(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BRK#NYSE">BRK</a>)</li>
<li>OpenAI</li>
<li>CoffeeMate, brand of Nestle (OTC:<a class="ticker" href="https://www.benzinga.com/stock/NSRGY#OTC">NSRGY</a>)</li>
<li>NFL youth organizations</li>
<li>Ram Truck, brand of Stellantis (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/STLA#NYSE">STLA</a>)</li>
<li>Hellmann's, brand of Unilever (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UL#NYSE">UL</a>)</li>
<li>Pringles, brand of Kellanova (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/K#NYSE">K</a>)</li>
<li>Budweiser, brand of Anheuser-Busch InBev</li>
<li>Nike Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NKE#NYSE">NKE</a>)</li>
<li>NYU Langone Health</li>
<li>Novartis Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVS#NYSE">NVS</a>)</li>
</ul>
After End of Second Quarter, During Halftime, During Third Quarter:
<ul>
<li>IndyCar on Fox</li>
<li>MyFitnessPal</li>
<li>Yahoo!, brand of Apollo Global (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/APO#NYSE">APO</a>) and Verizon Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/VZ#NYSE">VZ</a>)</li>
<li>Southwest Airlines (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LUV#NYSE">LUV</a>)</li>
<li>Jewel-Osco, brand of Albertsons (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ACI#NYSE">ACI</a>)</li>
<li>Bayer Aspirin</li>
<li>"The Masked Singer" on Fox</li>
<li>Fox Nation streaming platform</li>
<li>On Holding (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ONON#NYSE">ONON</a>)</li>
<li>Angel Soft, brand of Georgia-Pacific</li>
<li>Reese's Lava Cup, brand of The Hershey Company (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HSY#NYSE">HSY</a>)</li>
<li>NFL ad</li>
<li>Tubi streaming platform, brand of Fox</li>
<li>Fox shows</li>
<li>Local ad</li>
<li>Local ad</li>
<li>Salesforce Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CRM#NYSE">CRM</a>)</li>
<li>DoorDash Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DASH#NASDAQ">DASH</a>)</li>
<li>Meta Platforms</li>
<li>Stand Up to Hate</li>
<li>Nerds</li>
<li>Lay's, brand of PepsiCo</li>
<li>"M3gan 2.0" trailer, distributed by Comcast</li>
<li>Taco Bell, brand of Yum! Brands (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/YUM#NYSE">YUM</a>)</li>
<li>Nerdwallet</li>
<li>Häagen-Dazs</li>
<li>Tubi</li>
<li>Fox Nation</li>
<li>Bud Light, brand of Anheuser-Busch InBev</li>
<li>Hims &amp; Hers Health Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIMS#NYSE">HIMS</a>)</li>
<li>Poppi</li>
<li>TV shows on Fox</li>
</ul>
After End of Third Quarter, During Fourth Quarter:
<ul>
<li>Salesforce Inc</li>
<li>Ramp</li>
<li>Tullamore Dew whiskey</li>
<li>Toyota (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TM#NYSE">TM</a>)</li>
<li>Sandals Resorts</li>
<li>Local Ad</li>
<li>Jeep, brand of Stellantis</li>
<li>Tubi streaming platform</li>
<li>Fox News</li>
<li>Stella Artois, brand of Anheuser-Busch InBev</li>
<li>Dove, brand of Unilever</li>
<li>Booking.com (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BKNG#NASDAQ">BKNG</a>)</li>
<li>UFL on Fox</li>
<li>Bosch</li>
<li>Totino's Pizza Rolls, brand of General Mills (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GIS#NYSE">GIS</a>)</li>
<li>GoDaddy (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GDDY#NYSE">GDDY</a>)</li>
<li>Fetch</li>
<li>TV shows on Fox</li>
</ul>
End of Game, Eagles win 40-22, Final Ad Spot After Game:
<ul>
<li>Progressive (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PGR#NYSE">PGR</a>)</li>
<li>Adidas (OTC:<a class="ticker" href="https://www.benzinga.com/stock/ADDYY#OTC">ADDYY</a>)</li>
<li>Cirkul</li>
<li>Vrbo, brand of Expedia Group (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EXPE#NASDAQ">EXPE</a>)</li>
<li>Universal Resorts</li>
<li>Energy Transfer (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ET#NYSE">ET</a>)</li>
</ul>
The list includes all the Super Bowl LIX commercials that aired from the playing of the national anthem to the first ad break after the Eagles won.
Read Also:<a href="https://www.benzinga.com/general/sports/25/02/43578857/if-you-invested-in-bitcoin-instead-of-buying-super-bowl-tickets-each-year-since-2012-heres-how-much-youd-have-today"> If You Invested in Bitcoin Instead of Buying Super Bowl Tickets Each Year Since 2012, Here&#8217;s How Much You&#8217;d Have Today</a>
Winners and Losers: While everyone will have their own favorites and ads they wish they'd never seen, here's a look at some of the winners and losers.
USA Today asks consumers to <a href="https://admeter.usatoday.com/2025">vote </a>on their favorite Super Bowl commercials each year via the Ad Meter.
Here are the top 10 highest rated ads as of Monday morning:
<ol>
<li>Budweiser – "First Delivery"</li>
<li>Lay's – "The Little Farmer"</li>
<li>Michelob Ultra – "The ULTRA Hustle"</li>
<li>Stella Artois – "David and Dave</li>
<li>NFL – "Somebody"</li>
<li>NFL – "Flag 50"</li>
<li>Bud Light – "Big Men on Cul-De-Sac"</li>
<li>Uber Eats – "Century of Cravings"</li>
<li>Hellmann's – "When Sally Met Hellmann's"</li>
<li>Pfizer – "Knock Out"</li>
</ol>
Here are the 10 lowest rated ads as of Monday morning:
<ol>
<li>Tubi – "The Z Suite"</li>
<li>Fetch – "The Big Reward"</li>
<li>CoffeeMate – "Foam Diva"</li>
<li>Cirkul – "You Got Cirkul"</li>
<li>OpenAI – "ChatGPT: The Intelligence Age"</li>
<li>Squarespace – "A Tale As Old As Websites"</li>
<li>T-Mobile – "A New Era in Connectivity"</li>
<li>DoorDash – "DashPass Math"</li>
<li>Hims &amp; Hers – "Sick of the System"</li>
<li>GoDaddy – "Act Like You Know"</li>
</ol>
The list of winners shows that Anheuser-Busch InBev continues the tradition of unforgettable Super Bowl beer ads once again, taking four places on the top 10 list.
The list of losers shows that companies like CoffeeMate and Hims &amp; Hers, which had their first ever Super Bowl commercials may not have hit the mark with consumers watching.
Read Next: 
<ul>
<li><a href="EXCLUSIVE: Is Super Bowl $7M Ad Cost Worth It? 61% Say No, 18% Say They Looked Up Companies After Last Year's NFL Championship">EXCLUSIVE: Is Super Bowl $7M Ad Cost Worth It? 61% Say No, 18% Say They Looked Up Companies After Last Year&#8217;s NFL Championship</a></li>
</ul>
Photo: Shutterstock

Sports

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ADDYY

BKNG

CART

CMCSA

CSGP

DASH

EXPE

FLUT

FOXA

GDDY

GOOG

GOOGL

INTU

MDLZ

NSRGY

ONON

PARA

PARAA

TMUS

UBER

Super Bowl Commercials 2025: Complete List of Super Bowl LIX Ads And Companies Behind Them

Guggenheim analyst Vamil Divan reiterates Pfizer (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) with a Buy and maintains $33 price target.

Price Target

Reiteration

Analyst Ratings

Guggenheim Reiterates Buy on Pfizer, Maintains $33 Price Target

Pfizer, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) shares moved higher on Wednesday. The sector has seen volatility amid Robert F. Kennedy Jr.&#8217;s nomination as the secretary of the Department of Health and <a href="https://www.benzinga.com/general/biotech/25/02/43463168/pfizer-q4-earnings-revenue-and-eps-beat-seagen-and-covid-19-products-show-strength-issues-strong-fy25-outlook">Human Services</a>.
The Details: According to <a href="https://www.nbcnews.com/politics/congress/senate-panel-advances-rfk-jrs-nomination-health-secretary-rcna190438">NBC</a>, the Senate Finance Committee voted 14-13 along party lines to pass Kennedy&#8217;s nomination to the full chamber for a final vote. Sen. Bill Cassidy (R-La.), who ultimately voted to advance the nomination, initially struggled with his decision.
Cassidy, who is a doctor and the chair of the Health, Education, Labor and Pensions Committee, voted to forward the nomination for a final vote after meeting with Kennedy and Vice President JD Vance. 
Kennedy committed to collaborating with the senator if confirmed. Cassidy said, &#8220;Mr. Kennedy and the administration committed that he and I would have an unprecedentedly close collaborative working relationship if he is confirmed. We will meet or speak multiple times a month.&#8221;
In addition, Kennedy pledged to keep the Centers for Disease Control and Prevention&#8217;s immunization advisory committee intact and to leave the agency&#8217;s statements affirming that vaccines do not cause autism on its website.
The volatility in the sector may stem from investors&#8217; concerns about Kennedy&#8217;s potential impact if confirmed as secretary. Specifically, investors might worry about changes in vaccine policies or regulations, which could affect the profitability of companies like Pfizer.
What Else: Pfizer reported earnings for the 2024 fiscal year fourth quarter on Tuesday after the market closed. It reported adjusted earnings per share of 63 cents, beating the analysts&#8217; estimate of 47 cents and sales of $17.76 billion, beating analysts&#8217; estimate of $17.40 billion.
Pfizer reaffirmed its guidance for 2025 fiscal-year revenue of $61 billion to $64 billion, compared to the analysts&#8217; estimate of $63.02 billion. The company guided adjusted earnings per share from $2.80 to $3, versus analysts estimate of $2.94.
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PFE Price Action: At the time of writing, Pfizer stock is closed 2.08% higher at $26.44, according to data from <a href="https://www.benzinga.com/pro/">Benzinga Pro</a>.
Photo: Shutterstock

Movers

What's Going On With Pfizer Shares Wednesday?

WIIM

Shares of vaccine stocks are trading higher as the sector sees volatility amid Robert F. Kennedy Jr.'s nomination as HHS secretary. Sen. Senator Bill Cassidy said Kennedy committed to cooperation and would not remove vaccine information from the CDC website if confirmed.

Pfizer Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) shares are trading lower Tuesday after the Senate Finance Committee voted to advance Robert F. Kennedy Jr.'s nomination for <a href="https://www.benzinga.com/25/02/43468887/robert-f-kennedy-nomination-advances-to-full-senate-vaccine-stocks-drop">Secretary of Health and Human Service</a>.
What&#8217;s Going On: The committee voted 14-13 along party lines, sending Kennedy's nomination to the full Senate for consideration. Kennedy, a vocal critic of vaccines, has a history of questioning their safety and efficacy, which has raised concerns among investors in pharmaceutical companies that manufacture them.
Republican Senator Bill Cassidy supported Kennedy's nomination despite voicing concerns about his stance on vaccines. Cassidy noted he had "very intense conversations" with Kennedy and Vice President J.D. Vance before deciding to vote in favor of advancing the nomination. He cited commitments from the administration on shared priorities, including healthy food initiatives and a "pro-American agenda."
The drop in vaccine-related stocks comes as investors weigh the potential impact of Kennedy's leadership on public health policy and the pharmaceutical industry. Insurance stocks could also see movement as Kennedy has expressed strong criticism of the industry. During his Senate hearings, he condemned what he called "rapacious behavior by insurance companies" and indicated he would support measures to curb abusive practices such as care denial and overcharging the government.
PFE Price Action: Pfizer shares were down 1.45% at $25.78 at the time of writing, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro.</a>
<figure class="wp-block-image size-large is-resized"><a href="https://bzresearch.myclickfunnels.com/benzinga-pro-content-webinar-registration/?utm_source=BZprocontent020425&amp;t=be2bearmibe3na1"><img loading="lazy" decoding="async" width="1024" height="538" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/04132754/Screenshot-2025-02-04-at-13.27.25-1024x538.png" alt="" class="wp-image-765451" style="width:393px;height:auto" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/04132754/Screenshot-2025-02-04-at-13.27.25-1024x538.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/04132754/Screenshot-2025-02-04-at-13.27.25-300x158.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/04132754/Screenshot-2025-02-04-at-13.27.25-768x403.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/02/04132754/Screenshot-2025-02-04-at-13.27.25.png 1512w" sizes="(max-width: 1024px) 100vw, 1024px" /></a></figure>
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Image Via Shutterstock.

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