| Aug 21, 2026 | Jason Adair | CHIEF BUSINESS OFFICER | SELL | 41.832K | $40.05 | $4.7M |
| Aug 19, 2026 | Katherine Rielly-Gauvin | DIRECTOR | SELL-OPTIONS | — | $38.31 | $3.9M |
| Aug 17, 2026 | Rajeev Saggar | CHIEF MEDICAL OFFICER | SELL | 29.534K | $39.41 | $5.8M |
| Jul 27, 2026 | Dana Boyle | CHIEF ACCOUNTING OFFICER | SELL | 1.600K | $87.53 | $140K |
| Jul 27, 2026 | Jason Adair | CHIEF BUSINESS OFFICER | SELL | 688.000 | $87.53 | $60K |
| Jul 22, 2026 | Stephen M Bloch | DIRECTOR | SELL | 200.000K | $88.93 | $17.8M |
| Jul 20, 2026 | Stephen M Bloch | DIRECTOR | SELL | 78.596K | $79.97 | $6.3M |
| Jul 13, 2026 | Sanjeev Khindri | CHIEF DEVELOPMENT OFFICER | SELL | 1.185K | $71.51 | $85K |
| Jul 10, 2026 | Sarah Krepp | CHIEF HUMAN RESOURCE OFFICER | SELL | 4.685K | $71.51 | $562K |
| Jul 10, 2026 | Michael Kaseta | CFO AND COO | SELL | 7.551K | $71.51 | $1.5M |
| Jul 10, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 7.082K | $71.51 | $2.5M |
| Jul 10, 2026 | Jason Adair | CHIEF BUSINESS OFFICER | SELL-OPTIONS | 2.388K | $71.51 | $562K |
| Jul 10, 2026 | Russell Schundler | GENERAL COUNSEL | SELL | 4.570K | $71.51 | $1.1M |
| Jul 10, 2026 | Rajeev Saggar | CHIEF MEDICAL OFFICER | SELL | 1.908K | $71.51 | $710K |
| Jul 10, 2026 | Scott Moomaw | CHIEF COMMERCIAL OFFICER | SELL | 2.073K | $71.51 | $682K |
| Jul 10, 2026 | Dana Boyle | CHIEF ACCOUNTING OFFICER | SELL | 5.823K | $71.51 | $644K |
| Jul 6, 2026 | Stephen M Bloch | DIRECTOR | SELL | 75.000K | $80.68 | $6.1M |
| Jul 1, 2026 | Stephen M Bloch | DIRECTOR | SELL | 25.000K | $79.47 | $2.0M |
| Jun 22, 2026 | Stephen M Bloch | DIRECTOR | SELL | 100.000K | $75.74 | $7.6M |
| Jun 12, 2026 | Stephen M Bloch | DIRECTOR | SELL | 196.111K | $71.45 | $14.0M |
| Jun 11, 2026 | Sarah Krepp | CHIEF HUMAN RESOURCE OFFICER | SELL | 24.880K | $70.28 | $1.7M |
| Jun 10, 2026 | Stephen M Bloch | DIRECTOR | SELL | 388.223K | $68.61 | $26.6M |
| Jun 8, 2026 | Sanjeev Khindri | CHIEF DEVELOPMENT OFFICER | SELL | 4.134K | $65.46 | $271K |
| Jun 8, 2026 | Stephen M Bloch | DIRECTOR | SELL | 220.835K | $64.64 | $14.3M |
| Jun 4, 2026 | Paul B Manning | — | SELL | 200.000K | $63.91 | $12.8M |
| Jun 4, 2026 | Stephen M Bloch | DIRECTOR | SELL | 84.800K | $64.95 | $5.5M |
| Jun 1, 2026 | Sarah Krepp | CHIEF HUMAN RESOURCE OFFICER | SELL | 276.000 | $60.87 | $17K |
| Jun 1, 2026 | Arthur S Kirsch | DIRECTOR | SELL | 30.000K | $57.71 | $1.7M |
| May 27, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 6.428K | $62.18 | $400K |
| May 21, 2026 | Raman Singh | DIRECTOR | SELL-OPTIONS | — | $34.78 | $1.5M |
| May 21, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 75.000K | $61.01 | $4.6M |
| May 19, 2026 | Caligan Partners LP, EDWARD DAVID JOHNSON | DIRECTOR | p / s | — | $59.98 | — |
| May 18, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 75.000K | $58.91 | $4.4M |
| May 13, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 75.000K | $57.32 | $4.3M |
| May 11, 2026 | Stephen M Bloch | DIRECTOR | SELL | 318.893K | $50.23 | $16.0M |
| May 8, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 75.000K | $45.89 | $3.4M |
| May 5, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 75.000K | $40.99 | $3.1M |
| Apr 27, 2026 | Dana Boyle | CHIEF ACCOUNTING OFFICER | SELL | 1.576K | $37.78 | $60K |
| Apr 27, 2026 | Jason Adair | CHIEF BUSINESS OFFICER | SELL | 688.000 | $41.65 | $29K |
| Apr 17, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 18.839K | $40.60 | $765K |
| Apr 14, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 53.300K | $40.21 | $2.1M |
| Apr 14, 2026 | Michael Kaseta | CFO AND COO | SELL | 52.419K | $21.46 | $5.5M |
| Apr 10, 2026 | Scott Moomaw | CHIEF COMMERCIAL OFFICER | SELL | 3.082K | $38.34 | $404K |
| Apr 10, 2026 | Jason Adair | CHIEF BUSINESS OFFICER | SELL-OPTIONS | 2.947K | $38.37 | $280K |
| Apr 10, 2026 | Dana Boyle | CHIEF ACCOUNTING OFFICER | SELL | 1.922K | $38.37 | $196K |
| Apr 10, 2026 | Michael Kaseta | CFO AND COO | SELL | 6.080K | $21.07 | $1.6M |
| Apr 10, 2026 | Sarah Krepp | CHIEF HUMAN RESOURCE OFFICER | SELL | 1.378K | $38.37 | $175K |
| Apr 10, 2026 | Rajeev Saggar | CHIEF MEDICAL OFFICER | SELL | 1.203K | $38.37 | $354K |
| Apr 10, 2026 | Russell Schundler | GENERAL COUNSEL | SELL | 3.525K | $38.37 | $525K |
| Apr 10, 2026 | Roger Jeffs | CHIEF EXECUTIVE OFFICER | SELL | 26.010K | $39.06 | $2.1M |
