L'intérêt à découvert pour Eli Lilly donne aux investisseurs une idée du degré auquel les investisseurs parient sur la baisse de l'action de Eli Lilly. Les données sur l'intérêt à découvert sont mises à jour toutes les deux semaines.

Eli Lilly (NYSE:LLY) Stock, Rapport sur les intérêts à découvert

Eli Lilly

Eli Lilly is a drug firm with a focus on neuroscience, cardiometabolic, cancer, and immunology. Lilly's key products include Verzenio for cancer; Mounjaro, Zepbound, Jardiance, Trulicity, Humalog, and Humulin for cardiometabolic; and Taltz and Olumiant for immunology.

Eli Lilly and Co

Liberty Media Corporation - Series A Liberty Live Common Stock

Liberty Live Group

LIBERTY LIVE SERIES B by Liberty Media Corporation

Liberty Media Corporation - Series C Liberty Live Common Stock

Tidal Trust II Defiance Daily Target 2X Long LLY ETF

Hims &amp; Hers Health Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIMS#NYSE">HIMS</a>) shares spiked higher in afternoon trading Tuesday after the company said it will offer Eli Lilly And Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) Zepbound <a href="https://www.benzinga.com/quote/HIMS">through its Telehealth platform</a>.
What To Know: In a blog post released Tuesday afternoon, Hims &amp; Hers Health announced that it&#8217;s expanding access to personalized weight loss care.
&#8220;We're committed to bringing our customers more treatment options that best suit their needs, and we've now expanded that choice even further by adding access to generic liraglutide and branded tirzepatide through our platform,&#8221; the company said.
Tirzepatide is the active ingredient in Eli Lilly&#8217;s diabetes and weight-loss drugs. Hims &amp; Hers said it will offer both Lilly&#8217;s Zepbound and Mounjaro on its platform, as well as generic versions of Novo Nordisk&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) liraglutide, per Reuters.
Check This Out: <a href="https://www.benzinga.com/economics/macro-economic-events/25/04/44588076/us-manufacturing-slips-into-contraction-as-tariff-driven-costs-hit-near-3-year-high">US Manufacturing Slips Into Contraction As Tariff-Driven Costs Hit Near 3-Year High</a>
&#8220;Medication helps the body manage the biological factors that affect weight. Nutrition fuels the body. Physical activity builds strength and resilience. And behavioral support helps form lasting habits that create real, lifelong change,&#8221; the company said.
&#8220;Through our platform, we're weaving all of these tools together to provide access to a truly comprehensive care experience to deliver the best solution for every individual.&#8221;
Hims &amp; Hers joins competitors Teladoc and LifeMD in offering Lilly&#8217;s Zepbound on its platform. The move comes after a U.S. judge shut down an injunction earlier this month that would have allowed companies to continue making compounded drugs. Regulators allow compounded versions of drugs to enter the market to meet demand when there is a shortage.
HIMS Price Action: <a href="http://benzinga.com/quote/hims">Hims &amp; Hers Health shares</a> were up 6.01% at $31.27 at the time of publication Tuesday afternoon, according to <a href="http://pro.benzinga.com">Benzinga Pro</a>.
Photo: Shutterstock.

News

Movers

Hims & Hers Health, Inc. Class A Common Stock

HIMS

Hims & Hers Health Stock Jumped Tuesday Afternoon: What Happened?

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders often look for circumstances when the market estimation of an option diverges away from its normal worth. Abnormal amounts of trading activity could push option prices to hyperbolic or underperforming levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>IRON</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>04/17/25</td>
<td>$50.00</td>
<td>$160.0K</td>
<td>4</td>
<td>2.0K</td>
</tr>
<tr>
<td>VRNA</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>05/16/25</td>
<td>$70.00</td>
<td>$55.4K</td>
<td>372</td>
<td>500</td>
</tr>
<tr>
<td>MRNA</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>01/16/26</td>
<td>$25.00</td>
<td>$28.3K</td>
<td>6.7K</td>
<td>302</td>
</tr>
<tr>
<td>HUM</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>04/17/25</td>
<td>$310.00</td>
<td>$25.5K</td>
<td>8.7K</td>
<td>173</td>
</tr>
<tr>
<td>AKRO</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>04/17/25</td>
<td>$40.00</td>
<td>$25.8K</td>
<td>0</td>
<td>150</td>
</tr>
<tr>
<td>HIMS</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>07/18/25</td>
<td>$37.00</td>
<td>$47.8K</td>
<td>839</td>
<td>114</td>
</tr>
<tr>
<td>LLY</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>05/16/25</td>
<td>$690.00</td>
<td>$37.0K</td>
<td>212</td>
<td>33</td>
</tr>
<tr>
<td>NVO</td>
<td>PUT</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>01/16/26</td>
<td>$77.50</td>
<td>$36.0K</td>
<td>1.4K</td>
<td>26</td>
</tr>
<tr>
<td>TMO</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>05/16/25</td>
<td>$470.00</td>
<td>$32.8K</td>
<td>2</td>
<td>11</td>
</tr>
<tr>
<td>MCK</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>01/15/27</td>
<td>$680.00</td>
<td>$124.6K</td>
<td>10</td>
<td>11</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These bullet-by-bullet explanations have been constructed using the accompanying table. 
• Regarding IRON (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IRON#NASDAQ">IRON</a>), we observe a call option trade with bearish sentiment. It expires in 16 day(s) on April 17, 2025. Parties traded 2000 contract(s) at a $50.00 strike. The total cost received by the writing party (or parties) was $160.0K, with a price of $80.0 per contract. There were 4 open contracts at this strike prior to today, and today 2000 contract(s) were bought and sold. 
• For VRNA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VRNA#NASDAQ">VRNA</a>), we notice a call option sweep that happens to be bearish, expiring in 45 day(s) on May 16, 2025. This event was a transfer of 241 contract(s) at a $70.00 strike. This particular call needed to be split into 19 different trades to become filled. The total cost received by the writing party (or parties) was $55.4K, with a price of $230.0 per contract. There were 372 open contracts at this strike prior to today, and today 500 contract(s) were bought and sold. 
• For MRNA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MRNA#NASDAQ">MRNA</a>), we notice a put option sweep that happens to be bearish, expiring in 290 day(s) on January 16, 2026. This event was a transfer of 59 contract(s) at a $25.00 strike. This particular put needed to be split into 12 different trades to become filled. The total cost received by the writing party (or parties) was $28.3K, with a price of $480.0 per contract. There were 6708 open contracts at this strike prior to today, and today 302 contract(s) were bought and sold. 
• Regarding HUM (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HUM#NYSE">HUM</a>), we observe a call option trade with bearish sentiment. It expires in 16 day(s) on April 17, 2025. Parties traded 37 contract(s) at a $310.00 strike. The total cost received by the writing party (or parties) was $25.5K, with a price of $690.0 per contract. There were 8768 open contracts at this strike prior to today, and today 173 contract(s) were bought and sold. 
• For AKRO (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AKRO#NASDAQ">AKRO</a>), we notice a call option sweep that happens to be bullish, expiring in 16 day(s) on April 17, 2025. This event was a transfer of 150 contract(s) at a $40.00 strike. This particular call needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $25.8K, with a price of $170.0 per contract. There were 0 open contracts at this strike prior to today, and today 150 contract(s) were bought and sold. 
• For HIMS (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIMS#NYSE">HIMS</a>), we notice a call option sweep that happens to be bearish, expiring in 108 day(s) on July 18, 2025. This event was a transfer of 90 contract(s) at a $37.00 strike. This particular call needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $47.8K, with a price of $532.0 per contract. There were 839 open contracts at this strike prior to today, and today 114 contract(s) were bought and sold. 
• Regarding LLY (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), we observe a put option trade with bullish sentiment. It expires in 45 day(s) on May 16, 2025. Parties traded 30 contract(s) at a $690.00 strike. The total cost received by the writing party (or parties) was $37.0K, with a price of $1236.0 per contract. There were 212 open contracts at this strike prior to today, and today 33 contract(s) were bought and sold. 
• Regarding NVO (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>), we observe a put option trade with bearish sentiment. It expires in 290 day(s) on January 16, 2026. Parties traded 24 contract(s) at a $77.50 strike. The total cost received by the writing party (or parties) was $36.0K, with a price of $1500.0 per contract. There were 1454 open contracts at this strike prior to today, and today 26 contract(s) were bought and sold. 
• For TMO (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TMO#NYSE">TMO</a>), we notice a call option trade that happens to be bearish, expiring in 45 day(s) on May 16, 2025. This event was a transfer of 10 contract(s) at a $470.00 strike. The total cost received by the writing party (or parties) was $32.8K, with a price of $3280.0 per contract. There were 2 open contracts at this strike prior to today, and today 11 contract(s) were bought and sold. 
• Regarding MCK (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MCK#NYSE">MCK</a>), we observe a call option trade with bearish sentiment. It expires in 654 day(s) on January 15, 2027. Parties traded 11 contract(s) at a $680.00 strike. The total cost received by the writing party (or parties) was $124.6K, with a price of $11330.0 per contract. There were 10 open contracts at this strike prior to today, and today 11 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more about unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Options

AKRO

IRON

MRNA

VRNA

10 Health Care Stocks With Whale Alerts In Today's Session

Financial giants have made a conspicuous bullish move on Eli Lilly. Our analysis of options history for Eli Lilly (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) revealed 156 unusual trades.
Delving into the details, we found 55% of traders were bullish, while 25% showed bearish tendencies. Out of all the trades we spotted, 108 were puts, with a value of $6,109,986, and 48 were calls, valued at $4,158,923.
<h3>Expected Price Movements</h3>
Analyzing the Volume and Open Interest in these contracts, it seems that the big players have been eyeing a price window from $390.0 to $1180.0 for Eli Lilly during the past quarter. 
<h3>Volume &amp; Open Interest Development</h3>
In terms of liquidity and interest, the mean open interest for Eli Lilly options trades today is 212.74 with a total volume of 6,503.00.
In the following chart, we are able to follow the development of volume and open interest of call and put options for Eli Lilly's big money trades within a strike price range of $390.0 to $1180.0 over the last 30 days.
<h3>Eli Lilly Option Activity Analysis: Last 30 Days</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1743524137_0.png" alt="Options Call Chart" />
<h3>Biggest Options Spotted:</h3>

<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Ask</th>
<th>Bid</th>
<th>Price</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th align="right">Open Interest</th>
<th align="right">Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>04/11/25</td>
<td>$22.45</td>
<td>$22.4</td>
<td>$22.4</td>
<td>$815.00</td>
<td>$223.7K</td>
<td align="right">54</td>
<td align="right">316</td>
</tr>
<tr>
<td>LLY</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>06/18/26</td>
<td>$87.3</td>
<td>$84.7</td>
<td>$85.94</td>
<td>$770.00</td>
<td>$222.7K</td>
<td align="right">10</td>
<td align="right">67</td>
</tr>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>04/11/25</td>
<td>$22.55</td>
<td>$22.35</td>
<td>$22.55</td>
<td>$815.00</td>
<td>$169.5K</td>
<td align="right">54</td>
<td align="right">115</td>
</tr>
<tr>
<td>LLY</td>
<td>PUT</td>
<td>SWEEP</td>
<td>NEUTRAL</td>
<td>06/18/26</td>
<td>$88.65</td>
<td>$82.95</td>
<td>$85.95</td>
<td>$770.00</td>
<td>$163.3K</td>
<td align="right">10</td>
<td align="right">34</td>
</tr>
<tr>
<td>LLY</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>06/18/26</td>
<td>$86.95</td>
<td>$84.85</td>
<td>$85.39</td>
<td>$770.00</td>
<td>$102.4K</td>
<td align="right">10</td>
<td align="right">133</td>
</tr>
</tbody>
</table>

<h3>About Eli Lilly</h3>
Eli Lilly is a drug firm with a focus on neuroscience, cardiometabolic, cancer, and immunology. Lilly's key products include Verzenio for cancer; Mounjaro, Zepbound, Jardiance, Trulicity, Humalog, and Humulin for cardiometabolic; and Taltz and Olumiant for immunology.
Having examined the options trading patterns of Eli Lilly, our attention now turns directly to the company. This shift allows us to delve into its present market position and performance
<h3>Where Is Eli Lilly Standing Right Now?</h3>
<ul>
<li>With a volume of 959,932, the price of LLY is down -1.09% at $816.88. </li>
<li>RSI indicators hint that the underlying stock may be approaching oversold.</li>
<li>Next earnings are expected to be released in 30 days.</li>
</ul>
<h3>Professional Analyst Ratings for Eli Lilly</h3>
In the last month, 1 experts released ratings on this stock with an average target price of $1100.0.
Unusual Options Activity Detected: Smart Money on the Move
Benzinga Edge's Unusual Options board spots potential market movers before they happen. See what positions big money is taking on your favorite stocks. <a href="https://www.benzinga.com/premium/ideas/benzinga-edge-checkout/?t=Be8be9arja3be22bz20&amp;adType=benzinga-insights&amp;ad=options-activity&amp;campaign=wallstreetadvantage">Click here for access</a>. 
&#x2A; Maintaining their stance, an analyst from Wells Fargo continues to hold a Overweight rating for Eli Lilly, targeting a price of $1100. 
Options are a riskier asset compared to just trading the stock, but they have higher profit potential. Serious options traders manage this risk by educating themselves daily, scaling in and out of trades, following more than one indicator, and following the markets closely.
If you want to stay updated on the latest options trades for Eli Lilly, <a href="https://www.benzinga.com/pro/">Benzinga Pro</a> gives you real-time options trades alerts.

Markets

Check Out What Whales Are Doing With LLY

Michael Kratsios, a former deputy to venture capitalist Peter Thiel and one of Silicon Valley's most influential tech policy figures, has taken charge of the U.S. government's AI strategy amid escalating competition with China's tech giants.
What Happened: Kratsios was confirmed by the Senate to lead the Office of Science and Technology Policy (OSTP) last week.
His appointment comes as the Donald Trump administration intensifies its scrutiny of China's growing AI capabilities, especially following the emergence of DeepSeek—a Chinese AI startup that developed a powerful model at <a href="https://in.benzinga.com/25/03/44392370/nvidia-destroys-420-billion-of-investor-wealth-since-deepseek-launch-valuation-hits-a-29-month-low-as-gtc-fails-to-ignite-stock">significantly lower costs</a> than its U.S. counterparts.
Having served in the first Trump administration and later overseeing research initiatives at the Department of Defense, Kratsios is no stranger to navigating the intersection of national security and technological innovation, <a href="https://www.wsj.com/politics/policy/trump-ai-michael-kratsios-peter-thiel-protege-1457e276?mod=hp_listb_pos3">reported</a> the Wall Street Journal.
See Also: <a href="https://www.benzinga.com/tech/25/03/44577187/sam-altman-led-openai-releases-open-weight-ai-model-with-reasoning-capabilities-as-deepseek-and-meta-taste-success">Sam Altman-Led OpenAI Releases Open-Weight AI Model With Reasoning Capabilities As DeepSeek And Meta Taste Success</a>
Before returning to government, Kratsios worked at Scale AI, a startup specializing in AI training data.
Now, one of Kratsios's immediate tasks is reviewing thousands of industry submissions for the administration's AI policy framework, the report noted.
He also brings a global perspective to the role, having previously advised U.S. allies against adopting Chinese telecom infrastructure, particularly Huawei Technologies's 5G equipment.
Kratsios will be working alongside other high-profile figures in the administration, including David Sacks, Trump's <a href="https://www.benzinga.com/24/12/42356067/venture-capitalist-david-sacks-appointed-as-white-house-ai-crypto-czar-by-trump">AI and crypto policy leader</a>, and Sriram Krishnan, a senior AI advisor.
Why It's Important: Previously, Chinese President Xi Jinping expressed concerns that the tensions with the U.S. <a href="https://in.benzinga.com/25/03/44161587/is-china-apprehensive-of-losing-the-trade-war-to-the-us-china-could-get-isolated-like-moscow-fears-xi-jinping">could lead to China&#8217;s isolation</a>, similar to the Soviet Union&#8217;s during the Cold War.
Moreover, in response to the U.S. economic offensive, China has reportedly been considering <a href="https://in.benzinga.com/news/global/25/03/44448798/china-ponders-export-limitations-to-quell-trumps-trade-onslaught">restricting certain exports</a> to the U.S.
In March 2025, the U.S. added over <a href="https://in.benzinga.com/news/global/25/03/44494896/us-adds-50-chinese-entities-to-export-restriction-list-curtailing-access-to-nvidia-amd-chips">50 Chinese entities to an export restriction</a> list, limiting their access to advanced technologies like those from Nvidia Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) and Advanced Micro Devices (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMD#NASDAQ">AMD</a>).
Meanwhile, China is <a href="https://in.benzinga.com/markets/25/03/44451449/china-courts-apple-pfizer-eli-lilly-amid-us-pressure-vice-premier-says-beijing-will-continue-to-improve-the-business-environment">actively courting multinational companies</a>, including Apple Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>) and Eli Lilly (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), to improve its business environment and attract foreign investment.
Photo by asiandelight on Shutterstock
Read Next:
<ul>
<li><a href="https://benzinga.com/25/03/44554189/openai-and-microsoft-back-mcp-standard-in-major-shift-toward-interoperable-ai-agents-that-can-think-click-and-navigate-the-web-but-google-ceo-sundar-pichai-appears-to-be-mulling-over-it-in-shakespearean-fashion-to-mcp-or-not-to-mcp" target="_blank" rel="noreferrer noopener">OpenAI And Microsoft Back MCP Standard For Web-Surfing AI Agents; Google's Sundar Pichai Asks A Shakespearean Question</a></li>
</ul>
Disclaimer:&nbsp;This content was partially produced with the help of&nbsp;<a href="https://www.benzinga.com/author/benzinga-neuro" target="_blank" rel="noreferrer noopener">Benzinga Neuro</a>&nbsp;and was reviewed and published by Benzinga editors.

Government

Tech

Media

AAPL

NVDA

Who Is Peter Thiel's Protégé, Michael Kratsios, Now Leading Trump's AI Strategy Amid Rising Tech Tensions With China

Eli Lilly And Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), on Sunday, announced <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/n44552764/lillys-lepodisiran-reduced-levels-of-genetically-inherited-heart-disease-risk-factor-lipoprotein-a" rel="noreferrer noopener">positive Phase 2 results</a> for lepodisiran, an investigational small interfering RNA (siRNA) therapy designed to lower the production of lipoprotein(a) [Lp(a)], a genetically inherited risk factor for heart disease.
In the Phase 2 ALPACA study, lepodisiran significantly reduced Lp(a) levels by an average of 93.9% over the 60 to 180-day period after treatment with the highest tested dose (400 mg), meeting the primary endpoint.
Participants who received the 16 mg and 96 mg lepodisiran doses experienced a 40.8% reduction and a 75.2% reduction in Lp(a) levels over the same time period, respectively.
Also Read: <a target="_blank" href="https://www.benzinga.com/25/03/44544761/european-drug-regulator-gives-thumbs-down-to-eli-lillys-alzheimers-drug-analyst-says-it-is-incremental-win-for-biogen" rel="noreferrer noopener">European Drug Regulator Gives Thumbs Down To Eli Lilly&#8217;s Alzheimer&#8217;s Drug, Analyst Says It Is Incremental Win For Biogen</a>
Lepodisiran also met additional secondary endpoints, showing reductions in Lp(a) levels following one or two administrations of each of the three tested doses across all timepoints assessed throughout the nearly 18-month-long study.
Results from additional secondary endpoints showed:
<ul>
<li>Participants who received 400 mg of lepodisiran at both baseline and day 180 experienced a 94.8% reduction in average Lp(a) levels over the day 30 to 360 period, which remained 91.0% below baseline at day 360 (~1 year) and 74.2% below baseline at day 540 (~1.5 years).</li>
<li>Lepodisiran also reduced apolipoprotein B (apoB) levels, a separate cholesterol biomarker.</li>
<li>The highest dose (400 mg) of lepodisiran showed 14.1% and 13.7% ApoB reductions from baseline at day 60 and 180, respectively. A second 400 mg lepodisiran dose at day 180 sustained these apoB reductions through day 540.</li>
</ul>
Treatment-emergent adverse events (TEAEs) related to the study drug occurred in 1% (1/69) of the placebo group, 3% (1/36) of the 16 mg group, 12% (9/74) of the 96 mg group, and 14% (20/141) of the pooled 400 mg group. There were no serious adverse events related to lepodisiran treatment.
A single death occurred in the 16 mg dose group due to complications of chronic coronary disease.
One participant in the placebo group was withdrawn from the study drug due to a TEAE; however, no participants receiving lepodisiran experienced a TEAE leading to withdrawal from treatment or the study.
The ACCLAIM-Lp(a) Phase 3 clinical development program, investigating the effect of lepodisiran on the reduction of cardiovascular events in adults with elevated Lp(a), is currently enrolling.
Price Action: LLY stock is down 1.42% at $810.86 at the last check Monday.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/25/03/44544107/rokus-next-chapter-analyst-sees-big-gains-from-streaming-and-ad-expansion" target="_blank" rel="noreferrer noopener">Roku&#8217;s Next Chapter: Analyst Sees Big Gains From Streaming And Ad Expansion</a></li>
</ul>
Photo via Shutterstock

Biotech

Large Cap

Health Care

General

Eli Lilly's Cholesterol Drug Reduces Genetic Heart Disease Risk Factor By 93.9%

Palatin Technologies Inc.&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PTN#NYSE">PTN</a>) on Monday reported topline data with co-administered melanocortin-4 receptor (MC4R) agonist bremelanotide plus glucagon-like peptide-1/gastric inhibitory polypeptide <a target="_blank" href="https://www.benzinga.com/topic/weight-loss" rel="noreferrer noopener">(GLP-1/GIP) tirzepatide</a>.
Eli Lilly And Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) tirzepatide is available as Mounjaro and Zepbound for diabetes and weight loss.
Topline data results from the study were highly statistically significant for the study&#8217;s primary endpoint, which was percent weight loss in patients for the co-administration of MC4R agonist bremelanotide plus&nbsp;GLP-1/GLP tirzepatide compared to placebo, over the <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/n44558732/palatin-announces-mc4r-agonist-bremelanotide-co-administered-with-glp-1gip-tirzepatide-meets-prima" rel="noreferrer noopener">8-week treatment period</a>.
<ul>
<li>The co-administered group had a 4.4% reduction in weight compared to 1.6% for the placebo group.</li>
</ul>
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/25/03/44536083/palatin-technologies-touts-positive-results-from-mid-stage-study-for-experimental-drug-for-ulcerative-colitis-halts-patients-enrollment-citing-strategic-focus" rel="noreferrer noopener">Palatin Technologies Touts Positive Results From Mid-Stage Study For Experimental Drug For Ulcerative Colitis, Halts Patients Enrollment Citing Strategic Focus</a>
The primary analysis for additive effect demonstrated that:
<ul>
<li>40% of patients in the co-administered group achieved a 5% reduction in their body weight, compared to 27% for the tirzepatide alone group.</li>
<li>27% of patients in the co-administered group achieved a 6% reduction in their body weight, compared to 13% for the tirzepatide alone group.</li>
<li>19% of patients in the co-administered group achieved a 7% reduction in their body weight, compared to 0% for the tirzepatide alone group.</li>
</ul>
Over 50% of the lost weight was regained within two weeks after treatment cessation in both the co-administration and the tirzepatide-only groups, a common occurrence following the discontinuation of&nbsp;GLP-1/GIP therapy.
The data indicated that weight regain was effectively halted in the MC4R agonist bremelanotide group.
Additionally, co-administration of the MC4R agonist with the&nbsp;GLP-1/GIP therapy showed no increase in safety or tolerability concerns among patients.
Further data analysis is ongoing, including exploratory endpoints such as body composition and body mass index.
Palatin is advancing the development of its next-generation MC4R long-acting peptide and oral small molecule compounds as stand-alone treatments, as well as in combination with&nbsp;GLP-1/GIP (incretin therapy), and as monotherapy for multiple genetic obesity disorders.
Investigational New Drug applications are expected to be submitted in the fourth quarter of calendar 2025, with clinical data expected in the first half of 2026.
Price Action: PTN stock is down 14.6% at $0.5656 at the last check Monday.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/markets/emerging-markets/25/03/44563420/despite-us-expansion-taiwan-semiconductor-reaffirms-commitment-to-home-base-with-new-initiatives-reuters" target="_blank" rel="noreferrer noopener">Despite US Expansion, Taiwan Semiconductor Reaffirms Commitment To Home Base With New Initiatives: Reuters</a></li>
</ul>
Photo via Shutterstock.

Equities

Palatin Technologies' Obesity Drug Co-Administered With Eli Lilly's Blockbuster Drug Shows 4.4% Reduction In Weight

<ul>
<li>In Phase 2 ALPACA results, lepodisiran significantly reduced levels of genetically inherited cardiovascular risk factor, with some patients sustaining reductions for nearly 1.5 years</li>
<li>These data were presented at the American College of Cardiology 2025 Scientific Sessions and simultaneously published in the New England Journal of Medicine (NEJM)</li>
</ul>

Reported Earlier, Lilly's Investigational siRNA Therapy Lepodisiran Shows Near-Complete Lp(a) Suppression For Up To 1.5 Years In Phase 2 Study

Benzinga examined the prospects for<a href="http://www.benzinga.com/trading-ideas" target="_blank" rel="noreferrer noopener"> many investors' favorite stocks</a> over the last week — here's a look at some of our top stories.
U.S. stock markets declined this week amid escalating trade tensions and inflation concerns. The S&amp;P 500 fell 2%, the Dow Jones Industrial Average dropped 1.7%, and the Nasdaq Composite decreased by 2.7%, marking one of the worst weeks in recent years.
President Donald Trump's announcement of a 25% tariff on imported automobiles and parts contributed to market volatility. Automotive stocks were notably impacted; General Motors (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GM#NYSE">GM</a>) tumbled over 7%, and Ford (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/F#NYSE">F</a>) slid 3.9%. Conversely, electric vehicle manufacturers like Tesla (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>) edged up 0.4%, as their U.S.-based production is less affected by the tariffs.
Beyond the auto sector, economic indicators added to investor unease. The Federal Reserve's preferred inflation gauge, the core Personal Consumption Expenditures (PCE) price index, rose 0.4% in February, bringing the annual rate to 2.8%, above the Fed's 2% target. Additionally, consumer spending data fell short of expectations, exacerbating fears of economic slowdown amid President Trump's tariff policies.
Benzinga provides daily reports on the stocks most popular with investors. Here are a few of this past week's most bullish and bearish posts that are worth another look.

The Bulls
<a href="https://www.benzinga.com/trading-ideas/long-ideas/25/03/44512999/chevron-hits-52-week-high-warren-buffetts-5th-largest-holding-is-on-fire-but-should-you-buy">"Chevron Hits 52-Week High: Warren Buffett's 5th Largest Holding Is On Fire — But Should You Buy?"</a>, by Surbhi Jain, reports that Chevron Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CVX#NYSE">CVX</a>) hit a 52-week high as rising oil prices and Warren Buffett's ongoing support strengthened investor confidence.
<a href="https://www.benzinga.com/media/25/03/44515782/microsoft-halts-expansion-plans-yet-analysts-still-rank-it-among-top-investment-picks">"Microsoft Halts Expansion Plans, Yet Analysts Still Rank It Among Top Investment Picks"</a>, by Anusuya Lahiri, explains why analysts remain bullish on Microsoft Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSFT#NASDAQ">MSFT</a>) despite the tech giant pausing major data center expansions amid concerns of AI overcapacity.
<a href="https://www.benzinga.com/analyst-ratings/upgrades/25/03/44477982/carvana-analyst-says-its-time-to-buy-the-potential-amazon-of-auto-retail">"Carvana Analyst Says It's Time To Buy The Potential ‘Amazon Of Auto Retail'"</a>, by Adam Eckert, reports that Morgan Stanley analyst Adam Jonas upgraded Carvana Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CVNA#NYSE">CVNA</a>) from Equal-Weight to Overweight, raising the price target from $260 to $280, citing the company's potential to dominate auto retail akin to Amazon.com Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>).
For additional bullish calls of the past week, check out the following:
<a href="https://www.benzinga.com/news/earnings/25/03/44504468/concentrix-shares-pop-on-strong-q1-results-raised-revenue-guidance">Concentrix Shares Pop On Strong Q1 Results, Raised Revenue Guidance</a>
<a href="https://www.benzinga.com/trading-ideas/technicals/25/03/44517249/stock-of-the-day-will-the-move-higher-in-sysco-continue">Stock Of The Day – Will The Move Higher In Sysco Continue?</a>
<a href="https://www.benzinga.com/trading-ideas/technicals/25/03/44460563/tesla-jumps-10-on-china-fsd-optimism-tariff-easing-hopes">Tesla Jumps 10% On China FSD Optimism, Tariff Easing Hopes</a>

The Bears
<a href="https://www.benzinga.com/general/biotech/25/03/44500068/novo-nordisk-stock-sinks-to-52-week-lows-weight-loss-boom-losing-steam">"Novo Nordisk Stock Sinks To 52-Week Lows: Weight Loss Boom Losing Steam?"</a>, by Surbhi Jain, reports that Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) shares have plunged 44% year-over-year, hitting a 52-week low amid investor concerns over competition from Eli Lilly and Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) and the company's recent $2 billion acquisition of rights to a Chinese obesity drug.
<a href="https://www.benzinga.com/trading-ideas/technicals/25/03/44513787/nike-stock-hits-52-week-lows-is-the-sneaker-king-losing-its-step">"Nike Stock Hits 52-Week Lows: Is The Sneaker King Losing Its Step?"</a>, by Surbhi Jain, shows Nike Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NKE#NYSE">NKE</a>) tumbling to a 52-week low as slowing sales in China and rising competition challenge the global sneaker giant's dominance.
<a href="https://www.benzinga.com/25/03/44475805/homebuilders-kb-home-lennar-cut-prices-as-homebuyer-demand-has-slowed-materially">"Homebuilders KB Home, Lennar Cut Prices As Homebuyer Demand Has Slowed Materially"</a>, by Erica Kollmann, reports that KB Home (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/KBH#NYSE">KBH</a>) and Lennar Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LEN#NYSE">LEN</a>) are reducing home prices and offering incentives as elevated mortgage rates have significantly dampened buyer demand.
For more bearish takes, be sure to see these posts:
<a href="https://www.benzinga.com/25/03/44517020/ev-maker-mullen-automotive-to-further-cut-costs-and-slash-workforce">EV Maker Mullen Automotive To Further Cut Costs And Slash Workforce: Details</a>
<a href="https://www.benzinga.com/25/03/44465410/snow-white-disappoints-at-box-office-will-remake-hurt-disneys-marvel-magic-in-2025">‘Snow White' Disappoints At Box Office: Will Remake Hurt Disney's Marvel Magic In 2025?</a>
<a href="https://www.benzinga.com/news/offerings/25/03/44511664/why-is-teslas-chinese-rival-nio-stock-diving-today">Why Is Tesla's Chinese Rival NIO Stock Diving Today? (UPDATED)</a>

Keep up with all the latest breaking news and trading ideas by following <a href="https://twitter.com/Benzinga" target="_blank" rel="noreferrer noopener">Benzinga</a><a href="http://twitter.com/Benzinga" target="_blank" rel="noreferrer noopener"> on X</a>.
Image created using artificial intelligence via Midjourney.

AMZN

CVNA

MSFT

TSLA

Benzinga Bulls And Bears: Chevron, Microsoft, Nike — And Tariffs Have Automotive Sector Reeling

Last week, Microsoft Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSFT#NASDAQ">MSFT</a>) co-founder and philanthropist Bill Gates lamented the growing divide between the U.S. and China, saying it's blocking access to critical climate and technology innovations.
What Happened: In a wide-ranging interview during an Express Adda event, Gates praised China's leadership in renewable energy, artificial intelligence, and battery technology, while expressing concern that geopolitical tensions are hindering global collaboration on major challenges like climate change.
"China has been absolutely a pioneer," Gates said, noting its dominance in solar panel manufacturing, battery innovation, and AI research. "It's a real shame for the world that the U.S.-China tension means that the willingness to access those goods is quite limited."
See Also:&nbsp;<a href="https://www.benzinga.com/tech/25/03/44506409/steve-jobs-warned-34-years-ago-about-america-being-hollowed-out-by-foreign-manufacturing-a-concern-trump-now-echoes" target="_blank" rel="noreferrer noopener">Steve Jobs Warned 34 Years Ago About America Being ‘Hollowed Out' By Foreign Manufacturing — A Concern Trump Now Echoes</a>
Gates underscored the scale of China's contributions, calling the country "out in front" on critical green technologies and saying its research institutions have achieved "deep" scientific capabilities.
He pointed to electric vehicles as an area where American tariffs are impeding progress, noting, "There just won't be many Chinese EVs sold in the United States" due to high import barriers.
Subscribe to the&nbsp;<a href="https://bztechtrends.beehiiv.com/subscribe" target="_blank" rel="noreferrer noopener">Benzinga Tech Trends newsletter</a>&nbsp;to get all the latest tech developments delivered to your inbox.
Why It's Important: Gates' comments come as the U.S. and China remain locked in strategic and economic competition, particularly around semiconductors, clean energy, and AI.
Earlier this week, the U.S. added over <a href="https://in.benzinga.com/news/global/25/03/44494896/us-adds-50-chinese-entities-to-export-restriction-list-curtailing-access-to-nvidia-amd-chips">50 Chinese entities to an</a> export restriction list, aiming to curb China&#8217;s advancements in AI and semiconductor technology. This move is part of a broader strategy to limit China&#8217;s access to cutting-edge technology from companies like NVIDIA Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) and Advanced Micro Devices, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMD#NASDAQ">AMD</a>).
Meanwhile, China has been <a href="https://in.benzinga.com/markets/25/03/44451449/china-courts-apple-pfizer-eli-lilly-amid-us-pressure-vice-premier-says-beijing-will-continue-to-improve-the-business-environment">actively courting multinational companies</a>, including Apple Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>) and Eli Lilly and Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), to improve its business environment amidst these pressures.
China is reportedly considering <a href="https://in.benzinga.com/news/global/25/03/44448798/china-ponders-export-limitations-to-quell-trumps-trade-onslaught">export restrictions</a> in response to U.S. economic actions.
Additionally, talks are ongoing about a <a href="https://in.benzinga.com/news/global/25/03/44235317/trump-xi-discuss-potential-birthday-summit-amid-rising-trade-tensions-report">possible &#8220;birthday summit&#8221; between</a> Donald Trump and Chinese President Xi Jinping in June.
<figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio"> 
<div class="wp-block-embed__wrapper">
<iframe loading="lazy" title="Bill Gates Exclusive Interview on Future of Tech, AI &amp; Global Impact &#x7C; Bill Gates Latest Interview" width="500" height="281" src="https://www.youtube.com/embed/Iq1yfTbrWyw?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe>
</div>
</figure>
Check out more of Benzinga&#8217;s Consumer Tech coverage by&nbsp;<a href="https://www.benzinga.com/topic/consumer-tech" target="_blank" rel="noreferrer noopener">following this link</a>.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/tech/25/03/44487688/signal-touts-gold-standard-encryption-as-trump-administration-leak-spotlight-intensifies-our-code-is-regularly-scrutinized" target="_blank" rel="noreferrer noopener">Signal Touts ‘Gold Standard' Encryption As Trump Administration Leak Spotlight Intensifies: ‘Our Code Is Regularly Scrutinized'</a></li>
</ul>
Disclaimer: This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.
Photo courtesy: Shutterstock

Global

Microsoft Co-Founder Bill Gates Praises China As A Pioneer In Solar, Batteries, And AI: Warns Tensions Are Stifling Global Innovation

LLY RISES 8 POINTS AFTER ALERT
<figure class="wp-block-image size-large"><img decoding="async" src="https://contributor-assets.benzinga.com/wp-content/uploads/2025/03/28202809/Screenshot-2025-03-28-at-4.24.08%E2%80%AFPM-996x1024.png" alt="" class="wp-image-9235" /></figure>
Eli Lilly &amp; Co. (LLY) today experienced a Power Inflow, a significant event for those who follow where smart money goes and value order flow analytics in their trading decisions.&nbsp;
Today, at 10:33 AM on March 28th, a significant trading signal occurred for Eli Lilly &amp; Co. (LLY) as it demonstrated a Power Inflow at a price of $821.70. This indicator is crucial for traders who want to know directionally where institutions and so-called "smart money" moves in the market. They see the value of utilizing order flow analytics to guide their trading decisions. The Power Inflow points to a possible uptrend in Lilly&#8217;s stock, marking a potential entry point for traders looking to capitalize on the expected upward movement. Traders with this signal closely watch for sustained momentum in Lillys stock price, interpreting this event as a bullish sign.
Signal description
Order flow analytics, aka transaction or market flow analysis, separate and study both the retail and institutional volume rate of orders (flow). It involves analyzing the flow of buy and sell orders, along with size, timing, and other associated characteristics and patterns, to gain insights and make more informed trading decisions. This particular indicator is interpreted as a bullish signal by active traders.&nbsp;
The Power Inflow occurs within the first two hours of the market open and generally signals the trend that helps gauge the stock&#8217;s overall direction, powered by institutional activity in the stock, for the remainder of the day.&nbsp;
By incorporating order flow analytics into their trading strategies, market participants can better interpret market conditions, identify trading opportunities, and potentially improve their trading performance. But let's not forget that while watching smart money flow can provide valuable insights, it is crucial to incorporate effective risk management strategies to protect capital and mitigate potential losses. Employing a consistent and effective risk management plan helps traders navigate the uncertainties of the market in a more controlled and calculated manner, increasing the likelihood of long-term success
If you want to stay updated on the latest options trades for LLY, <a href="https://benzinga.grsm.io/register174">Benzinga Pro</a> gives you real-time options trades alerts.&nbsp;
<a href="https://benzinga.com/apis?_gl=1&#x2A;1hlgn5i&#x2A;_ga&#x2A;MTY1NjE2NTYxMi4xNzE0NzQ4MTAy&#x2A;_ga_V7ZK73W7N0&#x2A;MTcxNDc0ODEwMi4xLjEuMTcxNDc0ODQyOC4wLjAuMA..">Market News and Data brought to you by Benzinga APIs</a> and include firms, like&nbsp; &nbsp; <a href="https://www.tradepulse.net">https://www.tradepulse.net</a>&nbsp; which are responsible for parts of the data within this article. 
&#xA9; 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
After Market Close UPDATE:The price at the time of the Power Inflow was $821.70. The returns on the High price ($829.78) and Close price ($822.51) after the Power Inflow are respectively 1.0% and 0.1%. The result underlines the importance of a trading plan that includes Profit Targets and Stop Losses that reflect your appetite for risk.
Past Performance is not indicative of future results

Technicals

Opinion

Signals

Trading Ideas

Eli Lilly Stock Up 1% After Key Signal, Despite S&P 500's ~2% Drop

President Trump Says Will Be Announcing Pharma Tariffs Soon

European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) issued an opinion that does not recommend Eli Lilly and Co's (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) donanemab be granted marketing authorization for the treatment of early symptomatic Alzheimer's disease. Lilly will seek <a target="_blank" href="https://www.benzinga.com/general/health-care" rel="noreferrer noopener">re-examination by CHMP</a>.
Kisunla (donanemab) is <a target="_blank" href="https://investor.lilly.com/news-releases/news-release-details/lillys-statement-about-chmp-opinion-issued-donanemab" rel="noreferrer noopener">used</a> to treat adults with early symptomatic Alzheimer's disease (AD), which includes mild cognitive impairment (MCI) or mild dementia stage of disease.
Also Read: <a target="_blank" href="https://www.benzinga.com/25/03/44175948/alzheimers-drugs-from-eli-lilly-and-biogen-still-deemed-too-costly-for-nhs-funding" rel="noreferrer noopener">Alzheimer's Drugs From Eli Lilly And Biogen Still Deemed Too Costly For NHS Funding</a>
In October 2024, Eli Lilly released results from the TRAILBLAZER-ALZ 6 Phase&nbsp;3b&nbsp;study to investigate different dosing regimens of donanemab and their effect on amyloid-related imaging abnormalities with edema/effusion (ARIA-E) in adults with early&nbsp;<a target="_blank" href="https://www.benzinga.com/general/biotech/24/10/41608511/eli-lilly-says-new-data-can-potentially-provide-path-to-improved-donanemab-profile-by-lower-risk-" rel="noreferrer noopener">symptomatic Alzheimer's disease</a>.
The data showed a reduction in amyloid-related imaging abnormalities with edema/effusion (ARIA-E) at the 24-week primary endpoint for people receiving a slightly modified titration of donanemab in adults with early symptomatic Alzheimer's disease.
On Thursday, Eli Lilly expanded its LillyDirect digital healthcare platform to offer connections to independent in-person and telehealth options for <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/n44513552/lillydirect-platform-expands-to-facilitate-access-to-alzheimers-disease-care" rel="noreferrer noopener">Alzheimer's patients in the U.S.</a>
William Blair views "the CHMP's negative opinion on Kisunla as unsurprising, given the initial negative opinion for Leqembi, but nonetheless view it as an incremental win for Biogen Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BIIB#NASDAQ">BIIB</a>) and Eisai."
Analyst Myles Minter writes that given that the CHMP changed its stance to support Biogen's Leqembi after a formal review, it's highly likely that Lilly will challenge Friday's decision. Historically, appeals in European marketing application authorization (MAA) filings have led to a reversal about 25% of the time.
William Blair estimates that Leqembi's sales in the EU could reach $1.3 billion by 2031. Analyst Minter sees Leqembi as a growth driver for Biogen, especially if advancements like a potential subcutaneous version get approved. However, sales are growing more slowly than expected.
The analyst reiterates Biogen's Outperform rating but acknowledges that without substantial M&amp;A activity, this is a show-me story about returning to growth with the current portfolio.
Price Action: BIIB stock is down 1% at $138.92, and LLY stock is down 0.26% at $819.55&nbsp;at the last check Friday.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/general/biotech/25/03/44538151/european-commission-declines-to-renew-marketing-authorization-of-translarna-duchenne-muscular-disorder" target="_blank" rel="noreferrer noopener">European Commission Declines To Renew Marketing Authorization Of Translarna Duchenne Muscular Disorder</a></li>
</ul>
Image via Shutterstock

Analyst Color

Analyst Ratings

BIIB

European Drug Regulator Gives Thumbs Down To Eli Lilly's Alzheimer's Drug, Analyst Says It Is Incremental Win For Biogen

Eli Lilly (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) has outperformed the market over the past 20 years by 6.51% on an annualized basis producing an average annual return of 14.67%. Currently, Eli Lilly has a market capitalization of $738.30 billion. 
Buying $1000 In LLY: If an investor had bought $1000 of LLY stock 20 years ago, it would be worth $16,007.60 today based on a price of $822.00 for LLY at the time of writing.
<h3>Eli Lilly's Performance Over Last 20 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1743118208_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much $1000 Invested In Eli Lilly 20 Years Ago Would Be Worth Today

ONVO

Organovo Says with The Closing Of The Sale Of Its FXR Program To Lilly, It Has Received Upfront Payments And Anticipates Future Milestone Payments

Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) has been on a tear in the <a href="https://www.benzinga.com/topic/weight-loss-drug">weight loss drug</a> race, but its stock is slimming down for all the wrong reasons.
Shares have plunged 44.14% over the past year, 17.4% year-to-date, and 19.27% in the last month.
The Novo Nordisk stock fell to a fresh 52-week low of $72.15 — a far cry from its peak of $148.15.
<h2 class="wp-block-heading">NVO Stock Chart: A Bearish Picture</h2>
<figure class="wp-block-image size-full"><a href="https://www.benzinga.com/pro/?utm_source=BZprocontent&amp;t=be2bearmibe3na1"><img loading="lazy" decoding="async" width="631" height="489" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/26121310/Screenshot-2025-03-26-at-9.42.58-PM.png" alt="" class="wp-image-843028" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/26121310/Screenshot-2025-03-26-at-9.42.58-PM.png 631w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/26121310/Screenshot-2025-03-26-at-9.42.58-PM-300x232.png 300w" sizes="(max-width: 631px) 100vw, 631px" /></a></figure>
<a href="https://www.benzinga.com/pro/?utm_source=BZprocontent&amp;t=be2bearmibe3na1" target="_blank" rel="noreferrer noopener">Chart created using Benzinga Pro</a>
The stock is firmly in bearish territory, trading below its eight, 20, and 50-day exponential moving averages. It&#8217;s a sign that selling pressure isn't letting up. 
The eight-day simple moving average (SMA) of $77.11, 20-day SMA of $81.23 and 50-day SMA of $82.94 all flash bearish signals, while the 200-day SMA of $111.72 highlights just how deep this decline has been.
Adding insult to injury, the MACD (moving average convergence/divergence) reading of a negative 3.04 and RSI (relative strength index) of 32.37 suggest further downside risk.
Read Also: <a href="https://www.benzinga.com/insights/news/25/03/44474102/if-you-invested-1000-in-this-stock-5-years-ago-you-would-have-this-much-today">If You Invested $1000 In This Stock 5 Years Ago, You Would Have This Much Today</a>
<h2 class="wp-block-heading">A New Obesity Drug Bet: Too Little, Too Late?</h2>
While Novo Nordisk is busy betting on the future with its latest <a href="https://www.benzinga.com/general/biotech/25/03/44459637/novo-nordisk-to-pay-around-2-billion-for-obesity-drug-from-china-based-biotech">$2 billion deal</a> to acquire rights to a Chinese obesity drug from United Laboratories International, investors remain unimpressed. 
The treatment, UBT251, is designed to challenge Eli Lilly &amp; Co's (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) &#8216;Triple G&#8217; obesity drug, retatrutide, which has already shown promising weight loss results, <a href="https://www.cnbc.com/2025/03/25/healthy-returns-novo-nordisk-buys-united-laboratories-obesity-drug.html">reported</a> CNBC.
But with UBT251 still in early-stage trials, Lilly's blockbuster could hit the market first, leaving Novo Nordisk playing catch-up.
<h2 class="wp-block-heading">Trouble Ahead?</h2>
Novo Nordisk's weight loss empire is facing pressure on multiple fronts—technical signals scream bearish, competition is heating up, and Wall Street is questioning whether the company can maintain its dominance. 
As investors digest the latest drug deal, Novo Nordisk stock bulls may need more than a new obesity treatment to revive the stock's momentum. For now, the trend remains sharply downward.
Read Next: 
<ul>
<li><a href="https://www.benzinga.com/general/health-care/25/03/44490348/exclusive-vivani-medical-subdermal-semaglutide-implant-shows-20-weight-loss-in-animal-study-with-potential-for-once-yearly-dosing" target="_blank" rel="noreferrer noopener">EXCLUSIVE: Vivani Medical Subdermal Semaglutide Implant Shows 20% Weight Loss In Animal Study, With Potential For Once-Yearly Dosing</a></li>
</ul>
Image: Shutterstock

Novo Nordisk Stock Sinks To 52-Week Lows: Weight Loss Boom Losing Steam?

Active traders have new, highly powered tools at their disposal as Direxion rolls out four single-stock <a href="https://www.benzinga.com/topic/leveraged-etfs">leveraged and inverse exchange-traded funds.</a> 
These ETFs, focused on Eli Lilly &amp; Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) and Palo Alto Networks Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PANW#NASDAQ">PANW</a>), offer traders a way to multiply their bets—or hedge against downturns—in the booming pharmaceutical and cybersecurity sectors.
The latest additions include:
<ul>
<li>The Direxion Daily LLY Bull 2X Shares (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ELIL#NASDAQ">ELIL</a>)</li>
<li>Direxion Daily LLY Bear 1X Shares (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ELIS#NASDAQ">ELIS</a>)</li>
<li>The Direxion Daily PANW Bull 2X Shares (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PALU#NASDAQ">PALU</a>) and </li>
<li>Direxion Daily PANW Bear 1X Shares (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PALD#NASDAQ">PALD</a>).</li>
</ul>
Read Also: <a href="https://www.benzinga.com/markets/25/03/44451449/china-courts-apple-pfizer-eli-lilly-amid-us-pressure-vice-premier-says-beijing-will-continue-to-improve-the-business-environment">China Courts Apple, Pfizer, Eli Lilly Amid US Pressure, Vice Premier Says Beijing &#8216;Will Continue To Improve The Business Environment&#8217;</a>
<h2 class="wp-block-heading">Why Eli Lilly, Palo Alto Networks?</h2>
According to Direxion CEO Douglas Yones, these two stocks are prime candidates for leveraged trading given Eli Lilly's dominance in healthcare innovation and Palo Alto Networks' leading position in cybersecurity. 
The ETFs allow traders to play short-term moves in these stocks with amplified exposure &#8211; ideal for those looking to capitalize on momentum or protect against volatility.
Recent performance highlights the appeal: Eli Lilly has gained 9.99% in the past year but slid 6.85% over the last month, while Palo Alto Networks has soared 32.51% year-over-year and held a modest 0.21% gain in the past month.
<h2 class="wp-block-heading">High Risk, High Reward</h2>
While these ETFs open up fresh opportunities, they are not designed for buy-and-hold investors. Leveraged and inverse funds are built for short-term trading strategies and come with increased risk. Unlike traditional ETFs, these products track a single stock rather than an index, making them highly volatile.
For traders with a high-risk tolerance, Direxion's latest ETFs offer a way to trade fast-moving stocks with leverage. Just make sure to understand the risks before diving in.
Read Next: 
<ul>
<li><a href="https://www.benzinga.com/analyst-ratings/analyst-color/25/03/44463078/buy-the-dip-strategy-amid-market-chaos-why-a-billion-dollar-fund-is-buying-these-four-stocks">Buy-the-Dip Strategy Amid Market Chaos: Why A Billion Dollar Fund Is Buying These Four Stocks</a></li>
</ul>
Image: Shutterstock

Specialty ETFs

New ETFs

ETFs

ELIL

ELIS

PALD

PALU

PANW

Eli Lilly, Palo Alto Networks Traders Take Note: Direxion's New Leveraged ETFs Are Here

Everybody loves a great growth stock. We all know the stories of the incredible wealth delivered by fast-growing companies that keep growing for a long period of time.
Fortunes have been made by investors who correctly selected the best growth stocks and stayed invested for a long period of time regardless of economic changes and market gyrations.
With a seemingly endless supply of news and gyrations, as we start 2025, this is one of the most important lessons we can learn from market history.
Of course, finding and holding a great growth stock is not that easy.
For every Amazon, there are a dozen Pet.Coms, eToys and Webvans.
For every Bill Gates and Steve Jobs, there are thousands of others whose stabs at technological greatness are still in a box of useless junk in the back of a garage.
Here's a new tool to help you find the growth stocks that will last.
It is not enough to find these great companies to earn massive returns. You have to hold on through the market&#8217;s ups and downs and the endless wave of BS that the media will throw at the company over the years.
In bear markets, these stocks can get crushed.
Investors who are confident enough to not just hold on but buy more stand to make the kind of gains most people only dream about.
There is a reason that very few people make as much as they should off these great growth stocks.
Finding them and then holding them for a long time is hard to do.
This is where the new <a href="https://www.benzinga.com/screener/top-growth-stocks">Benzinga growth ranking</a> can help you become a better growth stock investor.
I designed these ratings to help identify companies with strong long-term growth prospects.
These companies are selling more of their products and services and seeing profits grow along with revenues. 
We are not looking for flash in the pan one hit wonder stocks. We want those that have been growing sales and profits and are likely to continue to do so.
Here are five companies that receive high grades from the Benzinga ranking system for growth right now:
Corporación América Airports S.A. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CAAP#NYSE">CAAP</a>) operates a portfolio of airports across Latin America and Europe, with its crown jewel assets in Argentina. This is a textbook example of an emerging market infrastructure play with monopolistic tendencies. CAAP controls hard-to-replicate assets that directly benefit from long-term air traffic growth, tourism recovery and currency normalization.
Despite facing Argentina&#8217;s well-documented macro risks, the business has turned the corner operationally, with international diversification and cost controls setting the stage for margin expansion.
Historically, CAAP&#8217;s sales have been cyclical, heavily impacted by Argentina&#8217;s economy and global air travel disruptions like the pandemic. Revenues collapsed in 2020 but have since rebounded sharply, with 2023 sales surpassing pre-pandemic levels. Earnings have been volatile but are stabilizing, with 2023 showing significant EBITDA growth and a return to profitability. The current trajectory suggests a multi-year upside if Argentina&#8217;s economy doesn&#8217;t implode.
Blue Bird Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BLBD#NASDAQ">BLBD</a>), the oldest U.S. school bus maker, has methodically pivoted into electric vehicles. While the core business is solid, the real story is the company&#8217;s leadership in EV school buses. With government funding pouring in and school districts warming up to electrification, Blue Bird is grabbing market share.
It's not flashy, but it is predictable and levered to a secular trend.
Blue Bird&#8217;s sales have historically been steady, reflecting school district budget cycles. Earnings were thin for years, but recent federal incentives for EV buses have ignited a surge in revenue and profits. Fiscal 2023 saw record sales and a massive jump in adjusted EBITDA, driven by higher pricing power and EV penetration. The company now boasts a record backlog, setting the table for continued growth.
NVIDIA Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) has transformed from a graphics chip designer into the undisputed leader of AI infrastructure. The company&#8217;s GPUs are now essential tools for training large AI models, creating a near-insurmountable moat. Its data center segment has become the primary growth engine, dwarfing the original gaming business. NVIDIA is the shovel seller in the AI gold rush and it sells every shovel it can make.
Historically, NVIDIA has delivered incredible top-line and bottom-line growth, particularly over the past five years. Revenue soared from $11 billion in 2019 to over $60 billion in 2024, with margins expanding alongside. EPS has followed suit, driven by both sales growth and operating leverage. The recent AI boom has supercharged growth, with triple-digit year-over-year revenue increases in recent quarters.
Eli Lilly and Company (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) has morphed into a pharmaceutical juggernaut, thanks largely to its success in diabetes and obesity treatments. Drugs like Mounjaro and Zepbound are redefining the market with massive commercial potential.
Combine that with a robust pipeline and Lilly&#8217;s execution, and you&#8217;ve got a healthcare powerhouse that&#8217;s just getting warmed up.
Historically, Lilly has grown revenue steadily, but the last three years have accelerated thanks to its metabolic drugs. Sales crossed $40 billion in 2023, up from $22 billion five years prior. Earnings have also exploded, with operating margins expanding due to high-margin drug sales.
The company&#8217;s forward growth outlook remains extremely strong.
Palantir Technologies Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PLTR#NASDAQ">PLTR</a>) is a unique software player, originally built for government intelligence and defense but is now making serious inroads into commercial markets.
Palantir&#8217;s platforms are sticky, complex, and mission-critical, which translates into strong pricing power and customer retention.
Historically, Palantir has posted consistent revenue growth north of 20% annually since going public. Sales have risen from $743 million in 2019 to over $2 billion in 2023. The company struggled with profitability early but recently posted GAAP profits, signaling a shift toward scale. Margins are improving as commercial contracts ramp, offering a compelling long-term growth story.
Earnings and sales growth across this group are either strong or downright explosive.
CAAP is rebounding nicely as air traffic picks up and Latin American economies stabilize, with recent double-digit revenue growth.
Blue Bird is riding the EV wave, posting record sales and margins as its backlog grows.
NVIDIA is simply a rocket ship, with sales and profits more than doubling as AI demand soars.
Eli Lilly is hitting its stride with obesity drugs, driving top and bottom-line growth at a blistering pace. Palantir is scaling into profitability while maintaining impressive revenue growth, setting up years of compounding ahead.
Simply put, these are companies in the right place at the right time, and the runway for continued growth looks wide open.
Finding Undervalued Stocks &amp; Managing Risk in a Volatile Market
Live on Tuesday, March 25, at 6 PM ET: Learn how to identify undervalued stocks with strong credit, protect your trades with options and take advantage of prime opportunities in today's volatile market with Tim Melvin, Ryan Faloona and Anne-Marie Baiynd. 
Register <a href="https://benzinga.zoom.us/webinar/register/WN_OJ2FBspHSJSSVNlW8zGapw">HERE</a> —spots are limited!
Photo: Shutterstock

BLBD

CAAP

PLTR

5 Stocks That Could Be The Next Nvidia

Whales with a lot of money to spend have taken a noticeably bullish stance on Eli Lilly.
Looking at options history for Eli Lilly (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) we detected 9 trades.
If we consider the specifics of each trade, it is accurate to state that 55% of the investors opened trades with bullish expectations and 33% with bearish.
From the overall spotted trades, 4 are puts, for a total amount of $203,125 and 5, calls, for a total amount of $303,548.
<h3>Projected Price Targets</h3>
Taking into account the Volume and Open Interest on these contracts, it appears that whales have been targeting a price range from $600.0 to $890.0 for Eli Lilly over the last 3 months. 
<h3>Analyzing Volume &amp; Open Interest</h3>
Looking at the volume and open interest is a powerful move while trading options. This data can help you track the liquidity and interest for Eli Lilly's options for a given strike price. Below, we can observe the evolution of the volume and open interest of calls and puts, respectively, for all of Eli Lilly's whale trades within a strike price range from $600.0 to $890.0 in the last 30 days. 
<h3>Eli Lilly Option Volume And Open Interest Over Last 30 Days</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1742824902_0.png" alt="Options Call Chart" />
<h3>Biggest Options Spotted:</h3>

<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Ask</th>
<th>Bid</th>
<th>Price</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th align="right">Open Interest</th>
<th align="right">Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>03/28/25</td>
<td>$12.3</td>
<td>$11.5</td>
<td>$12.08</td>
<td>$845.00</td>
<td>$97.1K</td>
<td align="right">287</td>
<td align="right">107</td>
</tr>
<tr>
<td>LLY</td>
<td>PUT</td>
<td>SWEEP</td>
<td>NEUTRAL</td>
<td>03/28/25</td>
<td>$10.5</td>
<td>$9.0</td>
<td>$9.67</td>
<td>$840.00</td>
<td>$96.5K</td>
<td align="right">467</td>
<td align="right">101</td>
</tr>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>09/19/25</td>
<td>$72.2</td>
<td>$71.1</td>
<td>$72.2</td>
<td>$880.00</td>
<td>$72.2K</td>
<td align="right">292</td>
<td align="right">1</td>
</tr>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>03/20/26</td>
<td>$131.15</td>
<td>$126.8</td>
<td>$128.0</td>
<td>$840.00</td>
<td>$64.0K</td>
<td align="right">15</td>
<td align="right">5</td>
</tr>
<tr>
<td>LLY</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>01/16/26</td>
<td>$90.9</td>
<td>$86.75</td>
<td>$86.75</td>
<td>$840.00</td>
<td>$43.3K</td>
<td align="right">643</td>
<td align="right">2</td>
</tr>
</tbody>
</table>

<h3>About Eli Lilly</h3>
Eli Lilly is a drug firm with a focus on neuroscience, cardiometabolic, cancer, and immunology. Lilly's key products include Verzenio for cancer; Mounjaro, Zepbound, Jardiance, Trulicity, Humalog, and Humulin for cardiometabolic; and Taltz and Olumiant for immunology.
In light of the recent options history for Eli Lilly, it's now appropriate to focus on the company itself. We aim to explore its current performance.
<h3>Present Market Standing of Eli Lilly</h3>
<ul>
<li>Trading volume stands at 186,963, with LLY's price up by 1.03%, positioned at $846.22.</li>
<li>RSI indicators show the stock to be is currently neutral between overbought and oversold.</li>
<li>Earnings announcement expected in 38 days.</li>
</ul>
<h3>What The Experts Say On Eli Lilly</h3>
1 market experts have recently issued ratings for this stock, with a consensus target price of $1100.0.
Unusual Options Activity Detected: Smart Money on the Move
Benzinga Edge's Unusual Options board spots potential market movers before they happen. See what positions big money is taking on your favorite stocks. <a href="https://www.benzinga.com/premium/ideas/benzinga-edge-checkout/?t=Be8be9arja3be22bz20&amp;adType=benzinga-insights&amp;ad=options-activity&amp;campaign=wallstreetadvantage">Click here for access</a>. 
&#x2A; An analyst from Wells Fargo has decided to maintain their Overweight rating on Eli Lilly, which currently sits at a price target of $1100. 
Options trading presents higher risks and potential rewards. Astute traders manage these risks by continually educating themselves, adapting their strategies, monitoring multiple indicators, and keeping a close eye on market movements. Stay informed about the latest Eli Lilly options trades with real-time alerts from <a href="https://www.benzinga.com/pro/">Benzinga Pro</a>.

Eli Lilly Unusual Options Activity

On Sunday, Chinese Vice Premier He Lifeng met with top executives from Apple Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>), Pfizer Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>), Mastercard Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MA#NYSE">MA</a>), Eli Lilly and Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), Cargill, and other major firms.
What Happened: "China will continue to improve the business environment and welcome more investment by multinational companies in China, sharing opportunities for development," he told the leaders, describing the country's economy as "highly resilient" and "full of vitality."
Executives from medical device maker Medtronic PLC (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MDT#NYSE">MDT</a>) and investment management firm Conning were also in attendance, reported Reuters, citing a statement from China's Ministry of Commerce.
However, the statement did not specify where the meeting took place.
Many of the executives are in Beijing to attend the China Development Forum, where further high-level meetings, including a possible session with President Xi Jinping, are expected later this week, the report noted, citing unnamed sources.
See Also:&nbsp;<a href="https://www.benzinga.com/25/03/44272657/alibaba-chairperson-says-everyone-is-concerned-about-tariffs-as-he-expects-levies-on-chinese-evs" target="_blank" rel="noreferrer noopener">Alibaba's Joseph Tsai Says ‘Everyone Is Concerned About Tariffs,' As He Expects Levies On Chinese EVs</a>
Why It's Important: Beijing has ramped up efforts to attract foreign capital amid a slowing economy and fresh <a href="https://in.benzinga.com/news/global/25/03/44448798/china-ponders-export-limitations-to-quell-trumps-trade-onslaught">U.S. tariff headwinds</a> under President Donald Trump.
While American companies made up the largest group at this year's forum, sources say fewer U.S. CEOs attended compared to last year—signaling ongoing caution in cross-border corporate relations, the report noted.
Previously, the Chinese President expressed concerns about the possibility of China facing isolation similar to the Soviet Union during the Cold War. The ongoing trade war has heightened <a href="https://in.benzinga.com/25/03/44161587/is-china-apprehensive-of-losing-the-trade-war-to-the-us-china-could-get-isolated-like-moscow-fears-xi-jinping">fears of economic isolation</a>.
 Despite these challenges, <a href="https://in.benzinga.com/general/market-summary/25/03/44273552/ray-dalio-says-china-is-way-ahead-in-ai-and-robotics-us-lags-in-mass-production">China remains a leader</a> in technological advancements, particularly in artificial intelligence and robotics, according to investor Ray Dalio.
Image via Shutterstock
Read Next:
<ul>
<li><a href="https://www.benzinga.com/news/25/02/44055314/mrbeast-lost-millions-on-amazons-beast-games-now-hes-looking-to-raise-hundreds-of-millions-to-take-h" target="_blank" rel="noreferrer noopener">MrBeast Lost Millions On Amazon's ‘Beast Games'—Now He's Looking To Raise Hundreds Of Millions To Take His Brand To The Next Level</a></li>
</ul>
Disclaimer:&nbsp;This content was partially produced with the help of&nbsp;<a href="https://www.benzinga.com/author/benzinga-neuro" target="_blank" rel="noreferrer noopener">Benzinga Neuro</a>&nbsp;and was reviewed and published by Benzinga editors.

Economics

China Courts Apple, Pfizer, Eli Lilly Amid US Pressure, Vice Premier Says Beijing 'Will Continue To Improve The Business Environment'

<a href="https://www.cnbc.com/2025/03/21/zepbound-copycats-tirzepatide-compounding-online-fda-ban.html">https://www.cnbc.com/2025/03/21/zepbound-copycats-tirzepatide-compounding-online-fda-ban.html</a>
<ul>
<li>Compounding pharmacies were largely supposed to stop making versions of tirzepatide this week, but it's still available on some popular websites like Amble, EllieMD, Willow and Mochi Health.</li>
<li>Pharmacies were able to make copycat versions of Eli Lilly's Zepbound and Mounjaro while the drugs were in shortage. But the FDA declared the shortage over late last year.</li>
<li>Mass compounding of Novo Nordisk's semaglutide — the active ingredient in Wegovy and Ozempic — is supposed to stop by the end of May.</li>
</ul>
This week was supposed to mark the end of <a href="https://www.cnbc.com/2024/12/24/fda-zepbound-shortage-impact-compounding-pharmacies-patients.html">compounding pharmacies</a> making copycat versions of <a href="https://www.cnbc.com/quotes/LLY/">Eli Lilly</a>'s weight-loss drug <a href="https://www.cnbc.com/2024/12/04/eli-lilly-zepbound-causes-more-weight-loss-than-novo-nordisk-wegovy-trial.html">Zepbound</a> and its diabetes drug Mounjaro. Online, it doesn't look like much has changed.&nbsp;
Popular websites like Amble, EllieMD, Willow and Mochi Health are all still advertising versions of tirzepatide, the active ingredient in Zepbound. Some, like Ivim, have stopped taking new patients.
&nbsp;
Mochi Health has no plans to stop, and neither do the four pharmacies it uses to supply patients with the medications, said Mochi CEO Myra Ahmad. The company uses a network of about 500 providers to write prescriptions for weight-loss drugs, including compounded versions. It's betting that offering personalized versions of the drugs will keep the company out of the crosshairs.&nbsp;
"It can be different dosing schedules … some patients prefer to go up in dosage much more slowly," Ahmad said. "Some patients like to mix a number of other medications into their compounded formulations, depending on the side effects that they're having. Some patients have side effects with any additives and brand name formulations. Compounding really opens up the door for so much personalization."&nbsp;
Amble, EllieMD and Willow didn't respond to CNBC's request for comment.&nbsp;
Compounding is where pharmacies mix ingredients of a drug to create a specialized version for specific patients. Say someone is allergic to a dye in a branded medication or needs a liquid form and the main manufacturer only sells capsules. In that case, the patient can turn to a compounded version.
When drugs are in shortage, they can be compounded in larger quantities to help fill the gap.&nbsp;
&nbsp;
Copycat versions of Lilly's Mounjaro and Zepbound and <a href="https://www.cnbc.com/quotes/NVO/">Novo Nordisk</a>'s Wegovy and Ozempic have been <a href="https://www.cnbc.com/2025/02/21/fda-shortage-of-novo-nordisks-wegovy-and-ozempic-drugs-is-resolved.html">widely available</a> in recent years because the U.S. Food and Drug Administration listed the brand versions as being in short supply.&nbsp;
That created a booming business for pharmacies compounding the highly popular class of weight loss and diabetes medications called <a href="https://www.cnbc.com/2024/05/14/healthy-returns-1-in-8-adults-have-taken-glp-1s-like-ozempic-survey.html">GLP-1s</a>.
But late last year, the FDA said all doses of Mounjaro and Zepbound were readily available and took the drug off its shortage list, spelling the end for mass compounding of the drug. After months of legal challenges, the FDA gave smaller pharmacies until early March to stop and larger pharmacies until this week before it started enforcing its rules.
The larger facilities aren't allowed to compound tirzepatide at all anymore. Smaller ones aren't supposed to make products that are essentially copies of a commercially available drug, a moniker with some wiggle room. The FDA sees essential copies as those that have a dosage within 10% of the commercially available drug or combine two or more commercially available drugs.
Mochi insists all of its prescriptions are personalized, including doses that differ from the standard Zepbound strengths. Other websites like EllieMD are advertising tirzepatide mixed with vitamin B12.&nbsp;
Scott Brunner, CEO of the Alliance for Pharmacy Compounding, said formulations or dosage strengths that aren't commercially available aren't considered a copy. However, combining two drugs into one — like adding vitamin B6 or B12 — would be considered a copy under a strict reading of FDA guidance.&nbsp;
"FDA guidance are pretty clear about what is and is not a copy," Brunner said. "And I would say any compounding pharmacy or outsourcing facility that continues to prepare copies of tirzepatide injection after today are putting themselves in a certain amount of legal risks."&nbsp;
John Herr, pharmacist and owner of Town &amp; Country Compounding Pharmacy, stopped compounding tirzepatide earlier this month. He didn't want to take the risk even though his 300 to 400 patients on it have been calling nonstop to complain about losing access.
Town &amp; Country, based in Ramsey, New Jersey, was charging patients about $200 a month — about one-fifth the list price for Zepbound and less than half the price Lilly charges self-paying patients.&nbsp;
What happens next is an open question. Enforcing the ban on mass compounding of tirzepatide mostly falls to the FDA. The agency didn't immediately respond to CNBC's request for comment.
Lilly can try to sue companies that continue, but it hasn't had much luck in the past. A Florida judge last year <a href="https://www.biospace.com/lilly-suffers-legal-loss-in-tirzepatide-case-against-compounding-pharmacy">dismissed</a> one of Lilly's cases, saying the company was trying to enforce a law that only the FDA can.&nbsp;
Ahmad, the CEO of Mochi, said she isn't worried about Lilly taking legal action against her providers. The way she sees it, they have established patient-physician relationships with the autonomy to decide how best to manage their patients.
The next two months will be informative. Mass compounding of <a href="https://www.cnbc.com/2025/02/21/fda-shortage-of-novo-nordisks-wegovy-and-ozempic-drugs-is-resolved.html">semaglutide</a> — the active ingredient in Novo Nordisk's Ozempic and Wegovy — needs to stop by the end of May, according to the FDA.
<a href="https://www.cnbc.com/quotes/HIMS/">Hims &amp; Hers Health</a> has already <a href="https://x.com/AndrewDudum/status/1896339552127824255">said</a> it will stop selling commercially available doses of semaglutide when the time comes. Customers who have a personalized dosing regimen will be able to continue without any change, the company added.&nbsp;

'Zepbound Copycats Remain Online Despite FDA Ban' - CNBC

Press Releases

Lilly's EBGLYSS® (lebrikizumab-lbkz) single monthly maintenance injection achieved completely clear skin at three years in half of patients with moderate-to-severe atopic dermatitis

Lilly's baricitinib delivered high rates of hair regrowth for adolescents with severe alopecia areata in Phase 3 BRAVE-AA-PEDS study

Contracts

Organovo Announces Close of the Sale of FXR Program to Eli Lilly and Company

Lilly announces details of presentations at 2025 American Association for Cancer Research (AACR) Annual Meeting

The Radoff-JEC Group Nominates Three Highly Qualified Candidates for Election to the Atea Pharmaceuticals Board of Directors

Organovo Provides Business Update

Global Radiotherapy Market Expected to Reach $9.62 Billion By 2030 Realizing Growth Due to Technological Advancements

LillyDirect platform expands to facilitate access to Alzheimer's disease care

Lilly's lepodisiran reduced levels of genetically inherited heart disease risk factor, lipoprotein(a), by nearly 94% from baseline at the highest tested dose in adults with elevated levels

Kanvas Bio Publishes New Research on its Novel Spectral Imaging Platform, a Transformative Tool for Microbiome Drug Discovery and Development

ABBV

ATNM

AVIR

CARM

COYA

INCY

MEIP

RIBT

SYBX

TSX:PHO

Axsome Therapeutics

AstraZeneca PLC - American Depositary Shares

AstraZeneca

Bristol-Myers Squibb Company Common Stock

Bristol-Myers Squibb

Corcept Therapeutics Incorporated - Common Stock

Corcept Therapeutics

Elanco Animal Health Incorporated Common Stock

Elanco Animal Health

GSK plc American Depositary Shares (Each representing two Ordinary Shares)

HUTCHMED (China) Limited - American Depositary Shares

HUTCHMED (China)

Haleon plc American Depositary Shares (Each representing two Ordinary Shares)

Haleon

Intra-Cellular Therapies Inc. - Common Stock

Jazz Pharmaceuticals plc - Ordinary Shares

Jazz Pharmaceuticals

Johnson & Johnson

Merck & Co

Novo Nordisk

Novartis

Organon

Prestige Consumer Healthcare Inc. Common Stock

Prestige Consumer

Pfizer

Dr. Reddy's Laboratories Ltd Common Stock

Dr Reddy's Laboratories

Royalty Pharma plc - Class A Ordinary Shares

Royalty Pharma

Sanofi

Takeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)

Takeda Pharmaceutical Co

Teva Pharmaceutical Industries Limited American Depositary Shares

Teva Pharmaceutical Indus

Verona Pharma plc - American Depositary Shares

Verona Pharma

Viatris

Zoetis

Wells Fargo

Truist Securities

Citigroup

B of A Securities

Wolfe Research

Untitled design - 2025-03-31T165341.547

TNXP

VRTX

Tonix&#39;s Experimental Non-Opioid Analgesic Treatment For Fibromyalgia Could Start Bringing Relief Later This Year

Screenshot 2025-02-24 at 11.35.34 PM

BRTX

BioRestorative Therapies Receives FDA Fast Track Approval For BRTX-100 To Treat Chronic Lumbar Disc Disease

Screenshot 2024-11-20 at 6.30.30 PM

BioRestorative Ends Q3 In &#39;Strong&#39; Financial Position, Reports Positive Data For Its Phase 2 BRTX-100 Chronic Back Pain Trial

Screenshot 2024-09-30 at 9.13.36 PM

The Rush For Non-Addictive Painkillers To Counter The Opioid Crisis Puts Two Companies Closer To FDA Decisions

Screenshot 2024-09-10 at 4.29.40 PM

Armed With Its Patent Portfolio, BioRestorative Therapies Has Success In The Laboratory And At The Negotiating Table: Is Profitability Close Behind?

Screenshot 2024-08-22 at 5.32.58 PM

RDHL

RedHill&#39;s Opaganib Shows Diabetes And Obesity Potential With Positive In Vivo Results

Screenshot 2024-07-10 at 9.08.28 PM

AXSM

A Redux Of The Lyrica-Cymbalta Fibromyalgia War Of The 2010s May Look More Like David Vs. Goliath

Screenshot 2024-06-18 at 1.15.14 AM

BioRestorative Therapies Enters Preclinical Assessment Of Its Patented Stem-Cell Technology Prior To First-In-Human Studies

Screenshot 2024-05-16 at 5.52.00 PM

ELAB

Elevai Labs (NASDAQ: ELAB) Acquires Rights To Develop Muscle Loss Prevention Assets For Anticipated Use In Anti-Obesity Treatments, Launches Two New Subsidiaries

Comments

Eli Lilly

Intérêt court

Eli Lilly (NYSE:LLY) Stock, Rapport sur les intérêts à découvert

Les gens regardent aussi

Notizie

PARTENAIRE / CONTRIBUTEUR

BENZINGA MONDIAL