La chaîne d'options affiche les données clés des options sur actions de Cullinan Therapeutics à différents prix d'exercice et dates d'expiration. Les traders utilisent ces informations pour analyser les transactions potentielles et évaluer le sentiment du marché pour Cullinan Therapeutics..

Cullinan Therapeutics (NASDAQ:CGEM) Stock, Chaîne d'Options

CULLINAN THERAPEUTICS INC

Cullinan Therapeutics

Cullinan Therapeutics Inc is a biopharmaceutical company. It has a diversified portfolio of clinical-stage assets that inhibit key drivers of disease or harness the immune system to eliminate diseased cells in both oncology and autoimmune diseases. Its understanding of oncology, immunology, and translational medicine, creates differentiated ideas, identifies the appropriate targets, and selects the optimal modality to develop transformative therapeutics across a variety of cancer and autoimmune indications. It has one reporting and one operating segment, which is the business of developing immunology and oncology therapies.

BofA Securities analyst Michael J. Funk <a href="https://www.benzinga.com/topic/telecommunications" target="_blank" rel="noreferrer noopener">reinstated coverage with</a> a Buy rating on T-Mobile US Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TMUS#NASDAQ">TMUS</a>) and separate company notes.
The telecom industry is often viewed as homogeneous. Still, Funk noted that AT&amp;T (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/T#NYSE">T</a>), rated as a Buy with a price target of $32; T-Mobile, rated Neutral with a price target of $255 and Verizon Communications Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/VZ#NYSE">VZ</a>), rated Neutral with a price target of $45, have unique characteristics tied to strategy, M&amp;A, metric prioritization and return on capital.
Also Read: <a href="https://www.benzinga.com/markets/tech/25/06/46069198/t-mobile-to-roll-out-satellite-data-service-this-october" target="_blank" rel="noreferrer noopener">T-Mobile Partners With Elon Musk&#8217;s SpaceX To Roll Out Satellite Data Service</a>
The analyst recommended a perceptive approach that prioritizes multiple expansion opportunities, return on capital, a well-defined fiber or wireless convergence strategy and estimates with greater upside potential than downside risk.
He noted that telecom stocks are under-owned by institutional investors and overlooked as being in a sleepy, mature industry.
However, since 2023, T-Mobile has posted a total return of 53%, AT&amp;T logged 84% and Verizon fell short of the S&amp;P 500 by 800bp at 27%, Funk wrote. Thus, the analyst said that company-specific factors, rather than industry strength or macro, are growing in importance as competition increases and strategies diverge.
AT&amp;T has the most excellent flexibility to compete effectively and return capital, which he noted as the best opportunity to drive stock performance.
Funk noted that AT&amp;T also offers the highest projected return on capital — dividends and buybacks in 2026 — at 7.2% of market cap.
The analyst noted that T-Mobile&#8217;s focus on net addition targets, coupled with a premium valuation, leaves less room for positive estimate revisions and multiple expansions.
He said Verizon is balancing responsible growth and protecting its premium subscriber base. Funk said its proposed acquisition of Frontier Communications adds execution uncertainty and should initially pressure free cash flow.
Territorial integrity is being tested, and competitive intensity is increasing, per the analyst. He noted that telcoms are expanding their broadband footprints through fiber builds, M&amp;A, joint ventures and fixed wireless access (FWA).
Funk noted that cable companies are signaling greater competition as they defend broadband markets and strive for broadband or wireless convergence. Consequently, the analyst noted fewer opportunities for price increases to be prevalent and drive growth in the price times quantity equation.
He said handset subsidies and buyout offers may increase as carriers and cable companies seek to catalyze churn, grow subscribers and lock in stickier converged customers.
Funk said executive and legislative actions, such as immigration and bonus depreciation, are tangential factors for telcom stock performance. The analyst noted the bonus tax depreciation passage was positive for AT&amp;T and Verizon and neutral for T-Mobile.
He estimated that reinstating bonus depreciation would increase AT&amp;T&#8217;s 2026E and 2027E free cash flow by 21% and 26%, respectively.
Immigration reform is a drag on wireless but is manageable, said Funk. The analyst estimated the immigration reform risk to be at least 2.1 million potential subscribers. However, he noted the risk is contained as 20% or less of subscribers at AT&amp;T, T-Mobile and Verizon are prepaid, and deep-value Mobile Virtual Network Operator (MVNO) brands are most likely to face material subscriber loss.
Price Actions: T-Mobile stock is down 1.18% at $237.91; Verizon is down 1.65% at $42.83 and AT&amp;T is slightly up at $28.34 at publication on Monday.
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Photo: Shutterstock

News

Price Target

Reiteration

Analyst Ratings

Trading Ideas

TMUS

Telecom Stocks Are No Longer One-Size-Fits-All, Analyst Says — Here's Which Company Stands Out

JP Morgan analyst Alexia Quadrani maintains Warner Music Gr (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WMG#NASDAQ">WMG</a>) with a Overweight and raises the price target from $32 to $33.

JP Morgan Maintains Overweight on Warner Music Gr, Raises Price Target to $33

BWG Global downgrades Chipotle Mexican Grill (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CMG#NYSE">CMG</a>) from Positive to Mixed.

Downgrades

BWG Global Downgrades Chipotle Mexican Grill to Mixed

Jones Trading analyst Jason Weaver initiates coverage on MFA Finl (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MFA#NYSE">MFA</a>) with a Hold rating.

Initiation

Jones Trading Initiates Coverage On MFA Finl with Hold Rating

Jefferies analyst Kelly Shi maintains Cogent Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/COGT#NASDAQ">COGT</a>) with a Buy and raises the price target from $23 to $28.

COGT

Jefferies Maintains Buy on Cogent Biosciences, Raises Price Target to $28

Circle Internet Group, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CRCL#NYSE">CRCL</a>) shares are trading over 7% higher Monday, extending a rally of more than 85% over the past month. Here&#8217;s a look at the key developments <a href="https://www.benzinga.com/node/45821941">fueling the move</a>.
What To Know: Circle, the issuer of the USDC stablecoin, kicked off June with an IPO priced at $31 per share. The stock opened for trading on the New York Stock Exchange at $69 per share and has continued to see strong momentum.
The IPO raised approximately $1.1 billion through the sale of 34 million Class A shares — 14.8 million from the company and 19.2 million from existing shareholders. Underwriters were also granted a 30-day option to purchase up to 5.1 million additional shares.
In late June, Circle shares continued <a href="https://www.benzinga.com/node/46056731">climbing after the</a> company announced a partnership with Fiserv to build stablecoin-enabled solutions for financial institutions and merchants within the Fiserv ecosystem.
The collaboration combines Circle's USDC platform and payments network with Fiserv's digital banking tools, expanding access to digital dollar infrastructure and connecting real-world payments to an internet-native financial layer.
Circle shares also got a boost after the Senate <a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/45995223/genius-stablecoin-bill-clears-senate-but-trumps-crypto-profits-loom-over-momentum" target="_blank" rel="noreferrer noopener">passed the GENIUS act</a>, or Guiding and Establishing National Innovation for U.S. Stablecoins Act. 
The stock has also attracted broad analyst attention over the last month, with several analysts initiating coverage with lofty price targets. Analyst firms including Needham, Cannacord Genuity and Barclays all announced price targets above $200.
Circle has a consensus price target of $183.75, according to Benzinga <a href="https://www.benzinga.com/quote/CRCL/analyst-ratings">analyst data</a>. Estimates range from a low of $80 to a high of $250.
Circle stock has rallied over 85% during the past month of trading, while the S&amp;P 500 has gained approximately 6.25%.
Related Link: <a href="https://www.benzinga.com/crypto/cryptocurrency/25/07/46278850/bonk-surges-58-in-7-days-why-is-it-outperforming-dogecoin-shiba-inu">Bonk Surges 58% In 7 Days: Why Is It Outperforming Dogecoin, Shiba Inu?</a>
CRCL Price Action: At the time of writing, Circle stock is trading 7.19% higher at $202.34, according to data from <a href="https://www.benzinga.com/pro/login">Benzinga Pro</a>.
Image via Shutterstock

Movers

CRCL

Circle Internet Group Stock Is Outperforming The S&P 500 Over The Past Month: What's Driving The Rally?

WIIM

UBER

Uber shares are trading higher after Wells Fargo maintained an Overweight rating and raised its price target from $100 to $120.

<a href="https://www.youtube.com/watch?v=Bi4eqS65UX8">https://www.youtube.com/watch?v=Bi4eqS65UX8</a>

Macro Notification

Politics

General

White House Says 12 Other Countries To Receive Trade Letters; Will Sign Executive Order Delaying July Deadline Of Tariffs To August 1; Letters Will Be Posted To Truth Social

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders will search for circumstances when the market estimation of an option diverges heavily from its normal worth. High amounts of trading activity could push option prices to exaggerated or underestimated levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>META</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>07/11/25</td>
<td>$730.00</td>
<td>$125.0K</td>
<td>4.6K</td>
<td>8.4K</td>
</tr>
<tr>
<td>GOOGL</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$190.00</td>
<td>$710.2K</td>
<td>12.9K</td>
<td>4.7K</td>
</tr>
<tr>
<td>GOOG</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>07/18/25</td>
<td>$177.50</td>
<td>$36.0K</td>
<td>2.3K</td>
<td>1.0K</td>
</tr>
<tr>
<td>ASST</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>12/19/25</td>
<td>$10.00</td>
<td>$112.9K</td>
<td>1.9K</td>
<td>215</td>
</tr>
<tr>
<td>TTD</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/18/26</td>
<td>$67.50</td>
<td>$195.5K</td>
<td>263</td>
<td>208</td>
</tr>
<tr>
<td>CHTR</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>01/15/27</td>
<td>$200.00</td>
<td>$45.9K</td>
<td>434</td>
<td>140</td>
</tr>
<tr>
<td>NFLX</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>07/11/25</td>
<td>$1250.00</td>
<td>$30.6K</td>
<td>234</td>
<td>99</td>
</tr>
<tr>
<td>ASTS</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>03/20/26</td>
<td>$60.00</td>
<td>$46.9K</td>
<td>538</td>
<td>57</td>
</tr>
<tr>
<td>DIS</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>08/15/25</td>
<td>$60.00</td>
<td>$31.7K</td>
<td>20</td>
<td>5</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These itemized elaborations have been created using the accompanying table. 
• For META (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/META#NASDAQ">META</a>), we notice a call option trade that happens to be bearish, expiring in 4 day(s) on July 11, 2025. This event was a transfer of 200 contract(s) at a $730.00 strike. The total cost received by the writing party (or parties) was $125.0K, with a price of $625.0 per contract. There were 4610 open contracts at this strike prior to today, and today 8468 contract(s) were bought and sold. 
• For GOOGL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GOOGL#NASDAQ">GOOGL</a>), we notice a call option sweep that happens to be bearish, expiring in 39 day(s) on August 15, 2025. This event was a transfer of 2000 contract(s) at a $190.00 strike. This particular call needed to be split into 61 different trades to become filled. The total cost received by the writing party (or parties) was $710.2K, with a price of $355.0 per contract. There were 12950 open contracts at this strike prior to today, and today 4725 contract(s) were bought and sold. 
• Regarding GOOG (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GOOG#NASDAQ">GOOG</a>), we observe a call option trade with bullish sentiment. It expires in 11 day(s) on July 18, 2025. Parties traded 100 contract(s) at a $177.50 strike. The total cost received by the writing party (or parties) was $36.0K, with a price of $360.0 per contract. There were 2370 open contracts at this strike prior to today, and today 1078 contract(s) were bought and sold. 
• For ASST (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ASST#NASDAQ">ASST</a>), we notice a call option sweep that happens to be bearish, expiring in 165 day(s) on December 19, 2025. This event was a transfer of 807 contract(s) at a $10.00 strike. This particular call needed to be split into 18 different trades to become filled. The total cost received by the writing party (or parties) was $112.9K, with a price of $140.0 per contract. There were 1910 open contracts at this strike prior to today, and today 215 contract(s) were bought and sold. 
• Regarding TTD (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TTD#NASDAQ">TTD</a>), we observe a call option sweep with bearish sentiment. It expires in 346 day(s) on June 18, 2026. Parties traded 100 contract(s) at a $67.50 strike. This particular call needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $195.5K, with a price of $1955.0 per contract. There were 263 open contracts at this strike prior to today, and today 208 contract(s) were bought and sold. 
• For CHTR (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CHTR#NASDAQ">CHTR</a>), we notice a call option trade that happens to be bearish, expiring in 557 day(s) on January 15, 2027. This event was a transfer of 2 contract(s) at a $200.00 strike. The total cost received by the writing party (or parties) was $45.9K, with a price of $22990.0 per contract. There were 434 open contracts at this strike prior to today, and today 140 contract(s) were bought and sold. 
• For NFLX (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NFLX#NASDAQ">NFLX</a>), we notice a call option trade that happens to be bullish, expiring in 4 day(s) on July 11, 2025. This event was a transfer of 7 contract(s) at a $1250.00 strike. The total cost received by the writing party (or parties) was $30.6K, with a price of $4385.0 per contract. There were 234 open contracts at this strike prior to today, and today 99 contract(s) were bought and sold. 
• For ASTS (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ASTS#NASDAQ">ASTS</a>), we notice a call option trade that happens to be bearish, expiring in 256 day(s) on March 20, 2026. This event was a transfer of 50 contract(s) at a $60.00 strike. The total cost received by the writing party (or parties) was $46.9K, with a price of $938.0 per contract. There were 538 open contracts at this strike prior to today, and today 57 contract(s) were bought and sold. 
• For DIS (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DIS#NYSE">DIS</a>), we notice a call option trade that happens to be bullish, expiring in 39 day(s) on August 15, 2025. This event was a transfer of 5 contract(s) at a $60.00 strike. The total cost received by the writing party (or parties) was $31.7K, with a price of $6352.0 per contract. There were 20 open contracts at this strike prior to today, and today 5 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more about unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Options

ASST

ASTS

CHTR

GOOG

GOOGL

NFLX

9 Communication Services Stocks With Whale Alerts In Today's Session

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders often look for circumstances when the market estimation of an option diverges away from its normal worth. Abnormal amounts of trading activity could push option prices to hyperbolic or underperforming levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>TSLA</td>
<td>PUT</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>07/11/25</td>
<td>$290.00</td>
<td>$27.4K</td>
<td>7.7K</td>
<td>77.5K</td>
</tr>
<tr>
<td>RIVN</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$15.00</td>
<td>$100.0K</td>
<td>30.7K</td>
<td>13.2K</td>
</tr>
<tr>
<td>AMZN</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>07/11/25</td>
<td>$222.50</td>
<td>$25.2K</td>
<td>1.7K</td>
<td>8.3K</td>
</tr>
<tr>
<td>BABA</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>09/19/25</td>
<td>$130.00</td>
<td>$53.1K</td>
<td>11.5K</td>
<td>2.0K</td>
</tr>
<tr>
<td>CMG</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>10/17/25</td>
<td>$62.50</td>
<td>$36.2K</td>
<td>216</td>
<td>1.8K</td>
</tr>
<tr>
<td>XPEV</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>08/15/25</td>
<td>$17.00</td>
<td>$46.1K</td>
<td>486</td>
<td>1.2K</td>
</tr>
<tr>
<td>GM</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>01/16/26</td>
<td>$57.50</td>
<td>$30.9K</td>
<td>2.4K</td>
<td>310</td>
</tr>
<tr>
<td>PDD</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>10/17/25</td>
<td>$120.00</td>
<td>$45.0K</td>
<td>1.5K</td>
<td>233</td>
</tr>
<tr>
<td>JD</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>01/16/26</td>
<td>$32.50</td>
<td>$57.6K</td>
<td>2.5K</td>
<td>169</td>
</tr>
<tr>
<td>MCD</td>
<td>PUT</td>
<td>SWEEP</td>
<td>NEUTRAL</td>
<td>08/15/25</td>
<td>$290.00</td>
<td>$30.2K</td>
<td>836</td>
<td>126</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These bullet-by-bullet explanations have been constructed using the accompanying table. 
• Regarding TSLA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>), we observe a put option trade with neutral sentiment. It expires in 4 day(s) on July 11, 2025. Parties traded 42 contract(s) at a $290.00 strike. The total cost received by the writing party (or parties) was $27.4K, with a price of $653.0 per contract. There were 7736 open contracts at this strike prior to today, and today 77537 contract(s) were bought and sold. 
• For RIVN (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RIVN#NASDAQ">RIVN</a>), we notice a call option trade that happens to be bearish, expiring in 39 day(s) on August 15, 2025. This event was a transfer of 2500 contract(s) at a $15.00 strike. The total cost received by the writing party (or parties) was $100.0K, with a price of $40.0 per contract. There were 30735 open contracts at this strike prior to today, and today 13289 contract(s) were bought and sold. 
• Regarding AMZN (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMZN#NASDAQ">AMZN</a>), we observe a put option sweep with bullish sentiment. It expires in 4 day(s) on July 11, 2025. Parties traded 100 contract(s) at a $222.50 strike. This particular put needed to be split into 4 different trades to become filled. The total cost received by the writing party (or parties) was $25.2K, with a price of $252.0 per contract. There were 1781 open contracts at this strike prior to today, and today 8309 contract(s) were bought and sold. 
• Regarding BABA (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BABA#NYSE">BABA</a>), we observe a call option sweep with bearish sentiment. It expires in 74 day(s) on September 19, 2025. Parties traded 292 contract(s) at a $130.00 strike. This particular call needed to be split into 12 different trades to become filled. The total cost received by the writing party (or parties) was $53.1K, with a price of $182.0 per contract. There were 11532 open contracts at this strike prior to today, and today 2027 contract(s) were bought and sold. 
• Regarding CMG (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CMG#NYSE">CMG</a>), we observe a call option sweep with bearish sentiment. It expires in 102 day(s) on October 17, 2025. Parties traded 250 contract(s) at a $62.50 strike. This particular call needed to be split into 14 different trades to become filled. The total cost received by the writing party (or parties) was $36.2K, with a price of $145.0 per contract. There were 216 open contracts at this strike prior to today, and today 1846 contract(s) were bought and sold. 
• Regarding XPEV (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/XPEV#NYSE">XPEV</a>), we observe a put option sweep with bullish sentiment. It expires in 39 day(s) on August 15, 2025. Parties traded 531 contract(s) at a $17.00 strike. This particular put needed to be split into 3 different trades to become filled. The total cost received by the writing party (or parties) was $46.1K, with a price of $87.0 per contract. There were 486 open contracts at this strike prior to today, and today 1293 contract(s) were bought and sold. 
• For GM (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GM#NYSE">GM</a>), we notice a call option trade that happens to be bullish, expiring in 193 day(s) on January 16, 2026. This event was a transfer of 103 contract(s) at a $57.50 strike. The total cost received by the writing party (or parties) was $30.9K, with a price of $300.0 per contract. There were 2413 open contracts at this strike prior to today, and today 310 contract(s) were bought and sold. 
• For PDD (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PDD#NASDAQ">PDD</a>), we notice a call option trade that happens to be bullish, expiring in 102 day(s) on October 17, 2025. This event was a transfer of 100 contract(s) at a $120.00 strike. The total cost received by the writing party (or parties) was $45.0K, with a price of $450.0 per contract. There were 1505 open contracts at this strike prior to today, and today 233 contract(s) were bought and sold. 
• For JD (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/JD#NASDAQ">JD</a>), we notice a call option sweep that happens to be bearish, expiring in 193 day(s) on January 16, 2026. This event was a transfer of 146 contract(s) at a $32.50 strike. This particular call needed to be split into 3 different trades to become filled. The total cost received by the writing party (or parties) was $57.6K, with a price of $395.0 per contract. There were 2513 open contracts at this strike prior to today, and today 169 contract(s) were bought and sold. 
• Regarding MCD (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MCD#NYSE">MCD</a>), we observe a put option sweep with neutral sentiment. It expires in 39 day(s) on August 15, 2025. Parties traded 53 contract(s) at a $290.00 strike. This particular put needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $30.2K, with a price of $570.0 per contract. There were 836 open contracts at this strike prior to today, and today 126 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

AMZN

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Citigourp Global Markets 2% Protected Notes Linked To The Djia

RIVN

TSLA

XPEV

10 Consumer Discretionary Stocks With Whale Alerts In Today's Session

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders will search for circumstances when the market estimation of an option diverges heavily from its normal worth. High amounts of trading activity could push option prices to exaggerated or underestimated levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>NVDA</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>07/11/25</td>
<td>$160.00</td>
<td>$90.6K</td>
<td>93.2K</td>
<td>122.5K</td>
</tr>
<tr>
<td>AAPL</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>07/11/25</td>
<td>$210.00</td>
<td>$61.3K</td>
<td>20.7K</td>
<td>19.3K</td>
</tr>
<tr>
<td>ORCL</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>07/11/25</td>
<td>$240.00</td>
<td>$34.2K</td>
<td>2.3K</td>
<td>15.3K</td>
</tr>
<tr>
<td>PLTR</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>07/11/25</td>
<td>$135.00</td>
<td>$50.9K</td>
<td>8.4K</td>
<td>14.0K</td>
</tr>
<tr>
<td>BTBT</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$3.00</td>
<td>$80.7K</td>
<td>15.9K</td>
<td>8.2K</td>
</tr>
<tr>
<td>DDOG</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>07/11/25</td>
<td>$155.00</td>
<td>$34.8K</td>
<td>4.0K</td>
<td>5.8K</td>
</tr>
<tr>
<td>AMD</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>09/19/25</td>
<td>$125.00</td>
<td>$38.0K</td>
<td>12.7K</td>
<td>3.7K</td>
</tr>
<tr>
<td>RGTI</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>10/17/25</td>
<td>$15.00</td>
<td>$112.7K</td>
<td>1.6K</td>
<td>3.0K</td>
</tr>
<tr>
<td>AI</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>07/18/25</td>
<td>$27.50</td>
<td>$28.2K</td>
<td>7.4K</td>
<td>1.1K</td>
</tr>
<tr>
<td>WDC</td>
<td>PUT</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$60.00</td>
<td>$150.0K</td>
<td>345</td>
<td>1.0K</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These itemized elaborations have been created using the accompanying table. 
• For NVDA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>), we notice a call option sweep that happens to be bearish, expiring in 4 day(s) on July 11, 2025. This event was a transfer of 537 contract(s) at a $160.00 strike. This particular call needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $90.6K, with a price of $168.0 per contract. There were 93233 open contracts at this strike prior to today, and today 122529 contract(s) were bought and sold. 
• For AAPL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>), we notice a call option sweep that happens to be bullish, expiring in 4 day(s) on July 11, 2025. This event was a transfer of 224 contract(s) at a $210.00 strike. This particular call needed to be split into 7 different trades to become filled. The total cost received by the writing party (or parties) was $61.3K, with a price of $275.0 per contract. There were 20716 open contracts at this strike prior to today, and today 19387 contract(s) were bought and sold. 
• For ORCL (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ORCL#NYSE">ORCL</a>), we notice a call option sweep that happens to be bearish, expiring in 4 day(s) on July 11, 2025. This event was a transfer of 199 contract(s) at a $240.00 strike. This particular call needed to be split into 5 different trades to become filled. The total cost received by the writing party (or parties) was $34.2K, with a price of $172.0 per contract. There were 2370 open contracts at this strike prior to today, and today 15369 contract(s) were bought and sold. 
• Regarding PLTR (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PLTR#NASDAQ">PLTR</a>), we observe a call option sweep with bearish sentiment. It expires in 4 day(s) on July 11, 2025. Parties traded 100 contract(s) at a $135.00 strike. This particular call needed to be split into 3 different trades to become filled. The total cost received by the writing party (or parties) was $50.9K, with a price of $509.0 per contract. There were 8451 open contracts at this strike prior to today, and today 14096 contract(s) were bought and sold. 
• For BTBT (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BTBT#NASDAQ">BTBT</a>), we notice a call option sweep that happens to be bearish, expiring in 39 day(s) on August 15, 2025. This event was a transfer of 1000 contract(s) at a $3.00 strike. This particular call needed to be split into 45 different trades to become filled. The total cost received by the writing party (or parties) was $80.7K, with a price of $80.0 per contract. There were 15949 open contracts at this strike prior to today, and today 8287 contract(s) were bought and sold. 
• Regarding DDOG (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DDOG#NASDAQ">DDOG</a>), we observe a call option sweep with bullish sentiment. It expires in 4 day(s) on July 11, 2025. Parties traded 200 contract(s) at a $155.00 strike. This particular call needed to be split into 20 different trades to become filled. The total cost received by the writing party (or parties) was $34.8K, with a price of $174.0 per contract. There were 4024 open contracts at this strike prior to today, and today 5861 contract(s) were bought and sold. 
• For AMD (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMD#NASDAQ">AMD</a>), we notice a call option sweep that happens to be bullish, expiring in 74 day(s) on September 19, 2025. This event was a transfer of 22 contract(s) at a $125.00 strike. This particular call needed to be split into 3 different trades to become filled. The total cost received by the writing party (or parties) was $38.0K, with a price of $1730.0 per contract. There were 12780 open contracts at this strike prior to today, and today 3757 contract(s) were bought and sold. 
• Regarding RGTI (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGTI#NASDAQ">RGTI</a>), we observe a call option sweep with bearish sentiment. It expires in 102 day(s) on October 17, 2025. Parties traded 500 contract(s) at a $15.00 strike. This particular call needed to be split into 20 different trades to become filled. The total cost received by the writing party (or parties) was $112.7K, with a price of $225.0 per contract. There were 1627 open contracts at this strike prior to today, and today 3046 contract(s) were bought and sold. 
• For AI (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AI#NYSE">AI</a>), we notice a call option trade that happens to be bullish, expiring in 11 day(s) on July 18, 2025. This event was a transfer of 912 contract(s) at a $27.50 strike. The total cost received by the writing party (or parties) was $28.2K, with a price of $31.0 per contract. There were 7417 open contracts at this strike prior to today, and today 1156 contract(s) were bought and sold. 
• Regarding WDC (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WDC#NASDAQ">WDC</a>), we observe a put option trade with bearish sentiment. It expires in 39 day(s) on August 15, 2025. Parties traded 1000 contract(s) at a $60.00 strike. The total cost received by the writing party (or parties) was $150.0K, with a price of $150.0 per contract. There were 345 open contracts at this strike prior to today, and today 1067 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

AAPL

BTBT

DDOG

NVDA

ORCL

PLTR

RGTI

10 Information Technology Stocks With Whale Alerts In Today's Session

Ramit Sethi is one of the few financial gurus who is okay with people spending their money on discretionary items. Some of these purchases may seem like a waste of money, and while he's okay with it, there are some caveats.&nbsp;
Sethi is only okay with people making those types of purchases if they can afford it, and there's one common mistake people make that convinces them that it's okay to bite more than they can chew. He's talking about people who <a href="https://www.youtube.com/watch?v=NgFZH47Tjoo">take out long-term loans</a> with monthly payments, and he's specifically pointing the finger at people who buy trucks.
"This is not a financial strategy. This is a trap," Sethi explains.
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Sethi went on to share that he's talked with many people who are struggling with their finances but somehow have a truck with a loan. There's a lot of pride involved in that truck, and monthly loan payments make it seem more affordable. Sethi breaks down why this type of thinking is flawed.
<h2 class="wp-block-heading">Do You Really Need The Truck?</h2>
Sethi angled some of the discussion specifically to people who buy trucks. He mentioned someone who earns $65,000 per year and bought a $90,000 truck with a loan. Sethi said that the person can't afford the truck even though the monthly loan payments fit in the budget.
The issue with using monthly loan payments in this way is that it takes up space in your monthly budget for multiple years. That's several years of not being able to invest that money or use it to cover expenses. Sethi explained that he's had many conversations with people who are in financial trouble because of their trucks and SUVs, but he then pondered if those individuals really need those vehicles.
It's possible to rent the vehicles instead or downgrade to a used model. He also finds it ironic that some of the same people who criticize women who buy expensive handbags proceed to buy trucks that they cannot afford.&nbsp;
Trending: Invest early in CancerVax's breakthrough tech aiming to disrupt a $231B market. <a href="https://www.benzinga.com/money/this-company-may-have-found-a-way-to-treat-cancer-by-tricking-the-bodys-immune-system-and-early-studies-show-some-promise-find-out-how-you-can-invest-in-the-future-of-cancer-treatment">Back a bold new approach to cancer treatment with high-growth potential.</a>
<h2 class="wp-block-heading">Interest Will Accumulate In Long-Term Loans</h2>
Most people need loans to buy homes and cars, but considering how interest accumulates in lengthy loans can make you think twice before buying something that you can't afford. All loans are amortized so that the bulk of your initial payments go toward interest.
Sethi explains that you can end up paying thousands of additional dollars by taking out a lengthy auto loan. While 30-year mortgages are the norm for homes, most people shouldn't be taking out seven-year auto loans.
You can find more affordable cars in the used car market and end up with a loan that has fewer years on it. Car dealers want you to think about covering something within your monthly budget because they can then have you commit to a long-term loan that has lower monthly payments. This may sound good at the moment, but interest payments will make the vehicle far more expensive.
See Also: Tired of Grid Failures and Charging Deserts? This Startup Has a Solar Fix and $25M+ in Sales — <a href="https://www.benzinga.com/money/meet-the-company-seeking-to-give-americans-energy-independence-and-learn-how-you-can-become-an-early-investor">Now Raising at $3/Share</a>
<h2 class="wp-block-heading">Pay Off Debt Quickly</h2>
A mortgage here and an auto loan there can quickly add up as you make your regular purchases each month. The gravity of debt can feel unsettling for people who are financially struggling, and that's why it is important to pay it off as quickly as possible.
If you make an additional payment toward your auto loan or mortgage each month, you get to directly reduce the principal instead of only making the amortized monthly payment. After paying off your auto loan, you can use that momentum to pay off your mortgage sooner.
It's incredibly freeing once you pay off your debt, but you shouldn't rush to put yourself in debt. Long-term loans restrict your ability to buy other products and services, and you should walk into any big purchase knowing how much you can afford. If you end up with a loan, it's a good idea to pay it off before it matures.
Read Next: Many are using retirement income calculators to check if they&#8217;re on pace —<a href="https://www.benzinga.com/money/how-do-i-calculate-my-retirement-income-adv"> here&#8217;s a breakdown on what&#8217;s behind this formula.</a>
Image: Shutterstock

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Ramit Sethi Explains How Opting For Monthly Loan Payments Can Hurt Your Financial Progress: 'This Is Not A Financial Strategy. This Is A Trap.'

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Reuters Cites EU Sources Saying EU Will Not Be Receiving Letter Setting Out Higher Tariffs From The United States

Strategy (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSTR#NASDAQ">MSTR</a>) on Monday announced the launch of a $4.2 billion ATM stock offering, aiming to scale its Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) holdings and <a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/45800186/bitcoin-stock-strategy-buy-or-sell-what-technicals-reveal-for-michael-saylors-mstr">enhance capital flexibility</a>.
What Happened: The <a href="https://www.strategy.com/strd-atm-launch-07-07-2025">offering</a> involves the sale of its 10.00% Series A Perpetual Stride Preferred Stock (STRD), as unveiled during an investor <a href="https://x.com/saylor/status/1942200866158596465">presentation</a> by CEO Phong Lee and Executive Chairman Michael Saylor.
The proceeds will be used to purchase more Bitcoin, fund general corporate operations, and support dividend payments for other preferred stock classes, including (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/STRK#NASDAQ">STRK</a>) and (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/STRF#NASDAQ">STRF</a>). 
The company plans to sell the shares in a gradual, market-aware manner, potentially via block trades or negotiated deals.
This move follows a brief pause in Bitcoin purchases from June 30 to July 6, marking the first break in BTC accumulation in over three months. In late May, Strategy <a href="https://www.benzinga.com/markets/cryptocurrency/25/05/45564703/strategy-unveils-2-1b-at-the-market-program-to-acquire-more-bitcoin">announced</a> a $2.1 billion ATM program for acquiring BTC.
The new offering is part of Strategy's expanded "42/42" capital plan, which aims to raise $84 billion for Bitcoin acquisitions by 2027, double its original "21/21" goal. The firm disclosed that the plan is already 38% complete.
In Q2, Strategy raised $6.8 billion via ATM sales of MSTR common stock and preferred shares STRK, STRF, and the initial STRD offering. Also Read: <a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/46168953/strategy-adds-4980-bitcoin-ups-total-stack-to-42-billion">Strategy Adds 4,980 Bitcoin, Ups Total Stack To $42 Billion</a>
Why It Matters: In a post on X on July 5, Saylor emphasized that MSTR, BTC, and STRK represent three forms of Bitcoin exposure.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true"><a href="https://twitter.com/search?q=%24MSTR&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$MSTR</a> is amplified Bitcoin. <a href="https://twitter.com/search?q=%24BTC&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$BTC</a> is pure Bitcoin. <a href="https://twitter.com/search?q=%24STRK&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$STRK</a> is structured Bitcoin. All three are winning this year. <a href="https://t.co/SzEa5ykOC2">pic.twitter.com/SzEa5ykOC2</a>
&mdash; Michael Saylor (@saylor) <a href="https://twitter.com/saylor/status/1941561468362604684?ref_src=twsrc%5Etfw">July 5, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
As of now, Strategy holds 597,325 BTC, worth over $65 billion, purchased at an average price of $70,982 per coin, totaling $42.4 billion in cost. This amounts to 2.8% of Bitcoin's total supply, resulting in $22.6 billion in unrealized profits.
In Q2, the company reported $14.05 billion in paper gains and a $4.04 billion deferred tax liability, highlighting the scale and impact of its crypto-focused strategy.
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President Donald Trump sent markets into a tailspin Monday after officially announcing sweeping 25% tariffs on all imports from Japan and <a href="https://www.benzinga.com/topic/tariffs">South Korea, starting Aug. 1. </a>
The new tariffs apply to all goods from the two Asian economies and are in addition to any existing sector-specific duties.
The new 25% tariffs follow earlier duties set on April 2 — 24% for Japan and 25% for South Korea — after the U.S. claimed trade barriers and currency practices raised effective rates to 46% and 50%, respectively. The hike comes after a 90-day negotiation window, announced April 9, which expired without deals.
In official letters sent to both governments, Trump said the tariffs are necessary to correct "unsustainable trade deficits" caused by "years of tariff and non-tariff policies and trade barriers." He added that any goods transshipped to evade the duties will be charged the higher rate.
Trump emphasized the measure was moderate, saying the 25% rate is "far less than what is needed to eliminate the trade deficit disparity." He also invited Japanese and South Korean firms to move production to the U.S., promising quick and professional regulatory approvals.
Trump stated that if trading partners were to raise their own tariffs, the U.S. would match that increase by adding the same percentage to its newly announced 25% tariff rate.
Earlier in the week, U.S. officials a separate deadline for reaching a deal with the European Union — before EU goods are subjected to duties of up to 50% — was set for Wednesday.
The tariff developments comes as the U.S. sets a separate deadline for reaching a trade agreement with the European Union. Without a deal, EU goods could face duties as high as 50%, compounding global trade concerns.
<h1 class="wp-block-heading">Stocks Slip, Dollar Rallies After Sweeping Tariffs</h1>
By midday trading in New York, the S&amp;P 500 dropped 0.9% to 6,220 points, while the Dow Jones Industrial Average tumbled 1.1%, losing more than 450 points to 44,320.
The CBOE Volatility Index (VIX) — also known as the market&#8217;s fear gauge — rallied 11%. Each S&amp;P 500 sector traded in the red with cyclical stocks underperforming. Tesla Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>) was the worst performer in both the S&amp;P 500 and the Nasdaq 100.
The EV giant sank 7.4% after Elon Musk announced the launch of the America Party, a new political movement aimed at challenging both Democrats and Republicans over federal spending in Washington. 
In currency markets, the U.S. dollar index surged 0.6%, marking its strongest session in nearly three weeks, as investors fled to the greenback amid rising global uncertainty.
The greenback jumped over 1% against the Japanese yen and gained 1.2% against the South Korean won.
U.S. Treasury yields moved higher, with the 10-year bond yield climbing four basis points to 4.39%. Higher tariffs typically stoke inflation fears, which in turn can pressure bond prices and lift yields.
Gold pared earlier losses, buoyed by demand for safe-haven assets in the face of rising trade tensions.
Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) edged down 0.7% to $108,000, extending its streak to 46 consecutive sessions without breaking its all-time high of $112,000.
<figure class="wp-block-table is-style-stripes"> 
<table class="has-fixed-layout">
<tbody>
<tr>
<td>Major Indices</td>
<td>Price</td>
<td>Chg %</td>
</tr>
<tr>
<td>Nasdaq 100</td>
<td>22,700.46</td>
<td>-0.7%</td>
</tr>
<tr>
<td>S&amp;P 500</td>
<td>6,223.21</td>
<td>-0.9%</td>
</tr>
<tr>
<td>Dow Jones</td>
<td>44,321.98</td>
<td>-1.1%</td>
</tr>
<tr>
<td>Russell 2000</td>
<td>2,212.65</td>
<td>-1.6%</td>
</tr>
</tbody>
</table>
<figcaption class="wp-element-caption">Updated by 1:00 p.m. ET</figcaption></figure>
According to&nbsp;<a href="https://www.benzinga.com/pro/?utm_source=BZprocontent&amp;t=be2bearmibe3na1">Benzinga Pro</a>&nbsp;data:
<ul class="wp-block-list">
<li>The&nbsp;Vanguard S&amp;P 500 ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/VOO#NYSE">VOO</a>) slumped 0.9% to $569.94.</li>
<li>The&nbsp;SPDR Dow Jones Industrial Average&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DIA#NYSE">DIA</a>) fell 1.1% to $443.18.</li>
<li>The tech-heavy&nbsp;Invesco QQQ Trust Series&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>)&nbsp;slipped 0.8% to $551.92.</li>
<li>The&nbsp;iShares Russell 2000 ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/IWM#NYSE">IWM</a>) tumbled 1.5% to $219.79.</li>
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Jasper Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/JSPR#NASDAQ">JSPR</a>) stock is experiencing a steep decline on Monday, plummeting by nearly 55%. This significant drop is accompanied by an exceptionally high trading volume of 9.9 million shares, vastly exceeding its average daily volume of 251.9K, according to data from <a href="https://www.benzinga.com/pro/feature/newsfeed">Benzinga Pro</a>.
<h2 class="wp-block-heading">What Happened?</h2>
The company reported updated data from the BEACON Phase 1b/2a study of subcutaneous briquilimab in adult chronic spontaneous urticaria (CSU) participants and provided an update on the program. It reported <a href="https://www.benzinga.com/pressreleases/25/01/g42869894/jasper-therapeutics-reports-positive-data-from-beacon-study-of-briquilimab-in-chronic-spontaneous-" target="_blank" rel="noreferrer noopener">preliminary data in January</a>.
The primary endpoints are briquilimab&#8217;s safety and tolerability, and the secondary endpoints are focused on <a target="_blank" href="https://www.benzinga.com/pressreleases/25/07/g46271172/jasper-therapeutics-reports-clinical-data-update-from-briquilimab-studies-in-chronic-spontaneous-u" rel="noreferrer noopener">clinical activity and PK/PD</a>.
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Primary measurements used to assess clinical activity were the sum of the Hives Severity Score and the daily Itch Severity Score (ISS), as measured via the Urticaria Activity Score over 7 days (UAS7) on a 0 to 42-point scale.
Briquilimab administration resulted in disease control in the 240mg and 360mg single-dose cohorts.
Eight of nine (89%) participants enrolled across both cohorts achieved a complete response, and seven of nine (78%) achieved a clinical response by week 2.
Reductions in UAS7 scores were reported with a mean change from baseline at 4 weeks of 28.3 points in the 240mg single-dose cohort and 22.9 points in the 360mg single-dose cohort.
In addition, BEACON participants who rolled over into the open-label extension study dosing at 180mg Q8W demonstrated clinical efficacy with 8 of 11 (73%) participants achieving a complete response at 12 weeks.
Results from the 240mg Q8W and the 240mg followed by 180mg Q8W dose cohorts appear to be confounded by an issue with one drug product lot used in those cohorts, with 10 of the 13 patients dosed with drug from the lot in question.
The company is investigating the drug product lot in question. It expects to have the investigation results in the coming weeks.
Key observations noted in those 10 patients were lower than expected drops in mean tryptase levels and no discernable impact on UAS7 scores. The 2 participants enrolled in the cohorts that have been confirmed as being dosed with drug product from a different lot both achieved complete response.
The company also plans to enroll an additional 10-12 patients across the 240mg Q8W and the 240mg followed by 180mg Q8W cohorts to ensure a robust data set to inform the Phase 2b CSU study.
Data from the additional BEACON patients is expected in the fourth quarter of 2025, and commencement of the Phase 2b study is now expected in mid-2026.
The company has also determined that the drug product lot in question was used to treat participants enrolled in the ETESIAN trial evaluating briquilimab in asthma.
<h2 class="wp-block-heading">Why It Matters?</h2>
To focus resources on advancing briquilimab in CSU, the company is halting the asthma study and pausing development.
In addition, the company is halting development in SCID and will implement several other cost-cutting measures, including a potential restructuring, to extend the runway and reduce expenses.
Briquilimab treatment also resulted in deep and durable disease control in the open-label extension study evaluating briquilimab at 180mg Q8W, with 8 of 11 participants (73%) achieving a complete response at the week 12 assessment.
Substantial reductions in tryptase were observed as early as the week 1 assessment and were correlated with the onset of clinical responses. Tryptase levels below the lower limit of quantification were reported for 8 of 10 (80%) participants across the 240mg and 360mg single-dose cohorts.
Briquilimab was tolerated well in the BEACON study and the open-label extension, with no dose-limiting toxicities observed.
Price Action: JSPR stock is down 54.5% at $3.08 at the last check on Monday.
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