Scholar Rock Holding Stock (NASDAQ: SRRK)

Dernières nouvelles pour Scholar Rock Holding (NASDAQ:SRRK) Stock

Scholar Rock Holding

Scholar Rock Holding Corp is a biopharmaceutical company. It is engaged in the discovery and development of innovative medicines for the treatment of serious diseases including neuromuscular disorders, cancer, fibrosis, and anemia. Geographically, the company operates in the United States. The company's product candidate is Apitegroma which is a selective, fully human, monoclonal antibody, with a mechanism of action that results in inhibition of the activation of the growth factor, myostatin, in skeletal muscle. Its other product comprises SRK-181, an inhibitor of the activation of latent transforming growth factor beta-1 ("TGFβ1"), for the treatment of cancers that are resistant to anti-PD-(L)1 antibody therapies.

Scholar Rock Holding Corporation - Common Stock

Scholar Rock Holding Corp

STOCK CLIMBS OVER 7% AT ITS HIGH, SIGNAL OCCURS AFTER EARLY WEAKNESS IN COIN
<figure class="wp-block-image size-full is-resized"><img loading="lazy" decoding="async" width="864" height="709" src="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/25210401/Screen-Shot-2024-11-25-at-4.08.18-PM.png" alt="" class="wp-image-3606" style="width:624px" srcset="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/25210401/Screen-Shot-2024-11-25-at-4.08.18-PM.png 864w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/25210401/Screen-Shot-2024-11-25-at-4.08.18-PM-300x246.png 300w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/25210401/Screen-Shot-2024-11-25-at-4.08.18-PM-768x630.png 768w" sizes="(max-width: 864px) 100vw, 864px" /></figure>
Coinbase Global, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/COIN#NASDAQ">COIN</a>) today experienced a Power Inflow, a significant event for those who follow where smart money goes and value order flow analytics in their trading decisions. 
Today, at 10:01 AM on November 25th, a significant trading signal occurred for Coinbase Global , Inc. as it demonstrated a Power Inflow at a price of $294.76. This indicator is crucial for traders who want to know directionally where institutions and so-called "smart money" moves in the market. They see the value of utilizing order flow analytics to guide their trading decisions. The Power Inflow points to a possible uptrend in Coinbase&#8217;s stock, marking a potential entry point for traders looking to capitalize on the expected upward movement. Traders with this signal closely watch for sustained momentum in Coinbase&#8217;s stock price, interpreting this event as a bullish sign.
Signal description
Order flow analytics, aka transaction or market flow analysis, separate and study both the retail and institutional volume rate of orders (flow). It involves analyzing the flow of buy and sell orders, along with size, timing, and other associated characteristics and patterns, to gain insights and make more informed trading decisions. This particular indicator is interpreted as a bullish signal by active traders.&nbsp;
The Power Inflow occurs within the first two hours of the market open and generally signals the trend that helps gauge the stock&#8217;s overall direction, powered by institutional activity in the stock, for the remainder of the day.&nbsp;
By incorporating order flow analytics into their trading strategies, market participants can better interpret market conditions, identify trading opportunities, and potentially improve their trading performance. But let's not forget that while watching smart money flow can provide valuable insights, it is crucial to incorporate effective risk management strategies to protect capital and mitigate potential losses. Employing a consistent and effective risk management plan helps traders navigate the uncertainties of the market in a more controlled and calculated manner, increasing the likelihood of long-term success
If you want to stay updated on the latest options trades for COIN, <a href="https://benzinga.grsm.io/register174">Benzinga Pro</a> gives you real-time options trades alerts.&nbsp;
<a href="https://benzinga.com/apis?_gl=1&#x2A;1hlgn5i&#x2A;_ga&#x2A;MTY1NjE2NTYxMi4xNzE0NzQ4MTAy&#x2A;_ga_V7ZK73W7N0&#x2A;MTcxNDc0ODEwMi4xLjEuMTcxNDc0ODQyOC4wLjAuMA..">Market News and Data brought to you by Benzinga APIs</a> and include firms, like <a href="https://finitusa.com/en/">Finit USA</a>, responsible for parts of the data within this article. 
&#xA9; 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved
After Market Close UPDATE:
The price at the time of the Power Inflow was $294.76. The returns on the High price ($317.46) and Close price ($312.30) after the Power Inflow were respectively 7.5% and 6.0%. That is why it is important to have a trading plan that includes Profit Targets and Stop Losses that reflect your risk appetite. In this case, the high of the day and close were very close but that is not always the case
Past Performance is Not Indicative of Future Results

Signals

Markets

General

COIN

Tradepulse Power Inflow Alert: Coinbase Global Inc. Climbs Over 20 Points After Signal

Bernard Looney, former CEO of oil and gas giant BP plc, said on Sunday he will join AI data center start-up, Prometheus Hyperscale, as the chairman of the <a href="https://www.prometheushyperscale.com/news/bernard-looney-appointed-chairman">board of directors. </a>
The Details: Looney resigned from his position at BP last year after an investigation <a href="https://www.theguardian.com/business/2023/sep/12/bp-boss-bernard-looney-to-resign-after-failing-to-reveal-ties-with-colleagues">revealed</a> he had not properly disclosed previous relationships with colleagues before becoming CEO. Looney is taking his more than 30 years of experience in the energy industry to the Wyoming-based start-up Prometheus Hyperscale.&nbsp;
Looney told the New York Times in an interview he would be helping Prometheus attract AI hyperscalers such as Microsoft and Google in need of power and space for data centers.&nbsp;
I'll be helping them with customers," he said. "I'll be helping them with investors. I'll be helping them with strategy."
Read More: <a href="https://www.benzinga.com/general/social-media/24/11/42119493/rumble-eyes-buying-bitcoin-could-it-be-the-next-microstrategy">Rumble CEO Considers Bitcoin Investment, Engages Michael Saylor As Shares Rally</a>
Prometheus plans to build a $10 billion flagship data center in Evanston, Wyoming, which will be among the largest facilities of its kind in the world when completed — the company estimates in 2025 or 2026. The company says the project encompasses a 12,000-acre ranch, including a dedicated 640-acre plot for data center facilities. 
The company secured an initial 120 MW of grid power through Rocky Mountain Power, with plans for an additional 120 MW, as well as a <a href="https://www.prometheushyperscale.com/news/oklo-partners-with-wyoming-hyperscale-to-deliver-100-megawatts-to-its-data-centers">strategic partnership</a> with Oklo Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/OKLO#NYSE">OKLO</a>) a small-scale nuclear reactor company.
Prometheus signed a non-binding letter of intent with Oklo in May, outlining its intent to enter into a 20-year Power Purchase Agreement.&nbsp;
"As the widespread adoption of artificial intelligence increases, Oklo remains dedicated to providing clean, reliable and affordable energy solutions to meet the needs of our data center partners. Our partnership with Wyoming Hyperscale underscores our commitment to advancing sustainable energy practices and supporting high-efficiency operations within the data center industry," Jacob DeWitte, CEO of Oklo, said in the announcement in May.&nbsp;
Combining the partnership with Oklo and its plans for incorporating a mix of wind, solar and gas power sources, Prometheus has an on-site generation goal of over 1 GW.&nbsp;
Looney said in the interview that he aims to help Prometheus Hyperscale address what he called downsides of A.I., including potential in emissions.&nbsp;
"We have to work on that," he said.
Read Next:&nbsp;
<ul>
<li><a href="https://www.benzinga.com/trading-ideas/movers/24/11/41949068/bitcoin-could-reach-1-million-by-2037-economist-says-buy-of-a-lifetime-opportunity">Bitcoin Could Reach $1 Million By 2037, Economist Says: &#8216;Buy Of A Lifetime&#8217; Opportunity</a></li>
</ul>
Photo: Courtesy of Prometheus Hyperscale

News

Management

Tech

OKLO

Former BP Oil CEO Joins AI Data Center Startup Prometheus Hyperscale

Scotiabank analyst Nicholas Yulico maintains Welltower (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/WELL#NYSE">WELL</a>) with a Sector Outperform and raises the price target from $133 to $142.

Price Target

Analyst Ratings

WELL

Scotiabank Maintains Sector Outperform on Welltower, Raises Price Target to $142

Scotiabank analyst Tanya Jakusconek maintains Barrick Gold (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GOLD#NYSE">GOLD</a>) with a Sector Outperform and lowers the price target from $24 to $23.

GOLD

Scotiabank Maintains Sector Outperform on Barrick Gold, Lowers Price Target to $23

Scotiabank analyst Greg Harrison maintains BridgeBio Pharma (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BBIO#NASDAQ">BBIO</a>) with a Sector Outperform and raises the price target from $45 to $48.

BBIO

Scotiabank Maintains Sector Outperform on BridgeBio Pharma, Raises Price Target to $48

Scotiabank analyst Eric Winmill maintains Gold Royalty (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/GROY#AMEX">GROY</a>) with a Sector Outperform and lowers the price target from $2.5 to $2.25.

GROY

Scotiabank Maintains Sector Outperform on Gold Royalty, Lowers Price Target to $2.25

Scotiabank analyst Ben Isaacson maintains Sociedad Quimica Y Minera (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SQM#NYSE">SQM</a>) with a Sector Outperform and lowers the price target from $60 to $50.

Scotiabank Maintains Sector Outperform on Sociedad Quimica Y Minera, Lowers Price Target to $50

Formula 1 is expanding with an 11th team joining the global motorsport for the 2026 season, naming General Motors (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GM#NYSE">GM</a>) <a href="https://www.benzinga.com/24/11/42135392/general-motors-gears-up-for-potential-f1-entry-in-2026-report">with Andretti Global.</a>
While the new team is still over a year away from starting, it will add an increased American presence to the sport and more competition for recent and four-time consecutive champion <a href="https://www.benzinga.com/general/education/21/12/24561188/max-verstappen-claims-his-first-f1-world-championship-5-things-you-might-not-know-about-the-for">Max Verstappen.</a>
What Happened: Formula 1, which is a unit of publicly traded Liberty Formula One (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/FWONA#NASDAQ">FWONA</a>)(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/FWONK#NASDAQ">FWONK</a>), announced it reached an agreement with General Motors for a new team, branded as Cadillac, which will enter beginning in 2026, following up a previous rejection of a GM-linked team <a href="https://www.benzinga.com/general/entertainment/24/01/36875148/formula-one-rejects-andretti-general-motors-team-bid-what-this-could-mean-for-us-growth-esp">earlier this year.</a>
General Motors will also become an engine supplier for the league at a later date, the league <a href="https://www.formula1.com/en/latest/article/statement-on-general-motors-application-to-join-fia-formula-one-world.69uoRF1uwHwXkr4efkpnhc">announced</a>. The GM team will use Ferrari engines until the GM engines are officially approved for the sport.
"With Formula 1's continued growth plans in the U.S., we have always believed that welcoming an impressive U.S. brand like GM/Cadillac to the grid and GM as a future power unit supplier could bring additional value and interest to the sport," Liberty Media CEO Greg Maffei said.
General Motors President Mark Reuss called Formula 1 the "pinnacle of motorsports" and said the announcement of becoming the 11th team is an honor for the automotive company.
"We're committed to competing with passion and integrity to elevate the sport for race fans around the world," Reuss said. "This is a global stage for us to demonstrate GM's engineering expertise and technology leadership at an entirely new level."
The approval of the team comes after the U.S. Justice Department launched an investigation into why Liberty Media, who owns the commercial rights to Formula 1, would not approve the American team bid started by Michael Andretti.
The new team, called Cadillac F1, will be run by Andretti Global majority owners Dan Towriss and Mark Walter after Andretti stepped aside from the group in September. Former Formula 1 champion and racing legend Mario Andretti will have an ambassador role with Cadillac F1 while his son Michael will have no official position.
Read Also: <a href="https://www.benzinga.com/general/entertainment/23/12/36222143/netflix-lands-more-live-sports-how-success-of-docuseries-helped-pave-the-way">Netflix Lands More Live Sports: How Success Of Docuseries Helped Pave The Way</a>
Why It's Important: The announcement comes after Formula 1's Las Vegas Grand Prix, one of three U.S. races in 2024, was recently held and saw Max Verstappen <a href="https://www.espn.com/f1/story/_/id/42520866/max-verstappen-wins-fourth-f1-world-title-las-vegas-red-bull">win </a>his fourth consecutive Formula 1 World Championship.
While Verstappen finished fifth in the race, he secured enough points to guarantee that no one could match his points total with two races left in the season. This marks the fourth consecutive title by Verstappen with his first title in 2021 a close one with<a href="https://www.benzinga.com/general/sports/24/02/36897433/f1-legend-lewis-hamilton-set-to-join-ferrari-likely-to-replace-sainz-in-major-team-shake-up"> racing legend Lewis Hamilton.</a>
Verstappen has been dominant in the sport in recent years winning the title with races still left in season three of the four years. Verstappen won seven of the first 10 races this season before falling out of form but later did enough to win enough points to secure the title.
The new GM team marks the second American-owned team. Gene Haas owns a team but chooses to have international drivers. Michael Andretti's original vision was to have an American-owned team and also feature American drivers, something that fans of the sport will be closely watching.
Team expansion has been infrequent with four teams added in 2010 to push the total to 13 teams and 26 cars. Of the four teams added, one never raced and the other three were out of the league by 2017, as <a href="https://apnews.com/article/f1-grid-expansion-11th-team-andretti-9ffab2a3b1c71d59bd838b1c154b690f?taid=6744c0a5988d9800014d4a8b&amp;utm_campaign=TrueAnthem&amp;utm_medium=AP&amp;utm_source=Twitter">reported </a>by the Associated Press. &nbsp;
The existing 10 team owners have been against expansion due to the dilution of prize money, but have no formal say in the approval process.
Adding another American team could benefit ESPN, which is a unit of Walt Disney Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DIS#NYSE">DIS</a>). ESPN secured the renewal of the U.S. rights in 2022, paying an estimated $75 million to $90 million annually for the rights for three additional years.
ESPN fought off several other parties interested in the rights, as viewership for the sport has surged in recent years.
Along with recent growth in viewership in the U.S. Formula One teams have also experienced increased interest in ownership stakes from investors, including several notable American football players.
The Alpine racing team received&nbsp;<a href="https://www.formula1.com/en/latest/article.patrick-mahomes-travis-kelce-anthony-joshua-and-rory-mcilroy-among-host-of.3J4ua82zLZnEDJuM5Cegpe.html" target="_blank" rel="noreferrer noopener">investments&nbsp;</a>in 2023 from Kansas City Chiefs players&nbsp;Patrick Mahomes&nbsp;and&nbsp;Travis Kelce, professional golfer&nbsp;Rory McIlroy&nbsp;and actor&nbsp;Ryan Reynolds.
FWONA Price Action: Liberty Formula One shares were up 4.25% to $80.74 on Monday, hitting an intraday high of $80.88, which is a new 52-week high. The stock is up 41% year-to-date in 2024.
Read Next: 
<ul>
<li><a href="https://www.benzinga.com/general/entertainment/24/09/41099414/ryan-reynolds-has-built-multiple-billion-dollar-brands-will-marketing-company-named-after-d">Ryan Reynolds&#8217; Billion-Dollar Streak: Will His Viral Marketing Firm Go Public Next?</a></li>
</ul>
Photo: Jay Hirano Photography via Shutterstock

Sports

Movers

Trading Ideas

FWONA

FWONK

Formula 1 Stock Hits 52-Week High, Announces 11th Team With General Motors/Andretti Global After Max Verstappen's Fourth Straight Title

SNBR

Sleep Number Issues Response To Public Letter To Shareholders From Stadium Capital Management; Reiterates That Its Highest Priority Is Identifying And Recruiting Optimal CEO Candidate

Scotiabank analyst Meny Grauman maintains Bank of Montreal (TSX:<a class="ticker" href="https://www.benzinga.com/stock/BMO#TSX">BMO</a>) with a Sector Outperform and raises the price target from C$112 to C$147.

TSX:BMO

Scotiabank Maintains Sector Outperform on Bank of Montreal, Raises Price Target to C$147

The Company expects the Restated Financial Statements to reflect the following approximate impacts: as of December 31, 2023, (i) an increase in assets of $190 million, (ii) an increase in accrued expenses and other liabilities of $783 million, and (iii) a decrease in retained earnings of $593 million.&nbsp;
For the years ended December 31, 2023 and 2022, pre-tax income would be reduced by approximately $190 million to $3,636 million and $77 million to $5,641 million, respectively. For the third quarter of 2024, pre-tax income would decrease by approximately $6 million to $1,282 million while pre-tax income for the nine months ended September 30, 2024 would increase by approximately $700 million to $4,462 million (as compared to the pre-tax income reported in the financial information with respect to the quarter ended September 30, 2024 in the exhibits furnished with the Company's Current Report on Form 8-K filed with the SEC on October 16, 2024).

Discover Financial Services Gets NYSE Notice Regarding Filing Of Form 10-Q; Plans To Restate Certain Prior Period Financial Statements

Scotiabank analyst Meny Grauman maintains Canadian Imperial Bank (TSX:<a class="ticker" href="https://www.benzinga.com/stock/CM#TSX">CM</a>) with a Sector Outperform and raises the price target from C$85 to C$108.

TSX:CM

Scotiabank Maintains Sector Outperform on Canadian Imperial Bank, Raises Price Target to C$108

Guidance

LexinFintech Says Cautious About Short-term Economic Outlook And Anticipate Recently Released Government Stimulus Measures Targeting Economic Recovery To Gradually Take Effect

Dividends

LexinFintech Board Approves Amended Dividend Payout Policy, Increasing Payout Ratio To 25% Of Net Profit Starting In 2025

Scotiabank analyst Meny Grauman maintains Royal Bank of Canada (TSX:<a class="ticker" href="https://www.benzinga.com/stock/RY#TSX">RY</a>) with a Sector Outperform and raises the price target from C$167 to C$197.

TSX:RY

Scotiabank Maintains Sector Outperform on Royal Bank of Canada, Raises Price Target to C$197

LexinFintech Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LX#NASDAQ">LX</a>) reported quarterly earnings of $0.28 per share. The company reported $521.85 in sales this quarter. This is a 100.00 percent decrease over sales of $480.94 million the same period last year.

Earnings

LexinFintech Holdings Q3 2024 Adj EPS $0.28, Sales $521.85M

Scotiabank analyst Meny Grauman maintains Toronto-Dominion Bank (TSX:<a class="ticker" href="https://www.benzinga.com/stock/TD#TSX">TD</a>) with a Sector Outperform and raises the price target from C$86 to C$98.

TSX:TD

Scotiabank Maintains Sector Outperform on Toronto-Dominion Bank, Raises Price Target to C$98

Flint, Michigan&#8217;s <a href="https://lightnupcannabis.com/">Light'N Up Cannabis Company</a> is helping local families in need celebrate Thanksgiving with its annual give away of 1,000 turkeys this past Saturday.
"Once you get something like this started, it takes on a life of its own and is more fun and more rewarding each year," said Light'N Up founder Kyle Cohee.
"We've been through some tough times here in Flint, and people deserve every single break we can provide," he said. "Giving them the central part of a Thanksgiving meal is our honor and our way of thanking the people of Flint for supporting our store."
The veteran-owned business set aside 300 of the 1,308 turkeys for Vet Life, a local nonprofit serving veterans. Another eight turkeys went to the North End Soup Kitchen and area churches to help others in need.
Country music artist and veteran advocate Stephen Cochran joined the event, adding to the day's community spirit.
See Also: <a href="https://www.benzinga.com/government/regulations/24/11/42173811/hemp-and-thanksgiving-from-the-mayflower-to-independence-the-crop-that-helped-build-a-nation">Hemp And Thanksgiving: From The Mayflower To Independence, The Crop That Helped Build A Nation</a>
<h3 class="wp-block-heading">Cannabis-Infused Thanksgiving In Arizona</h3>
Meanwhile, in Arizona, Mint Café, the state's first and only canna-kitchen, is putting a unique twist on Thanksgiving dinner. 
According to WDRB, the dispensary is offering a selection of cannabis-infused dishes, including THC-infused gravy, cranberry sauce, garlic herb butter and cornbread. For dessert, customers can choose between pumpkin and pecan pies, also infused with THC.
These special menu items will be available to adults 21 and older, providing an alternative way to enjoy a Thanksgiving feast.
Read Next: 
<ul>
<li><a href="https://www.benzinga.com/markets/cannabis/24/11/41843473/how-to-microdose-cannabis-for-a-stress-free-holiday-season-tips-for-newcomers">How To Microdose Cannabis For Stress-Free Holiday Season: Tips For Newcomers</a></li>
</ul>
Cover image made with AI.

Cannabis

Restaurants

1,000 Free Turkeys Donated By Michigan Dispensary, Cannabis-Infused Thanksgiving Feasts In Arizona

Citigroup analyst Michael Griffin maintains CBRE Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CBRE#NYSE">CBRE</a>) with a Buy and raises the price target from $130 to $160.

CBRE

Citigroup Maintains Buy on CBRE Group, Raises Price Target to $160

Nuveen California Dividend Advantage Municipal Fund 2

Trading Halt: Halted at 5:53:28 p.m. ET - Trading Halt: Halt News Pending

Scholar Rock Holding ( ($SRRK) ) has released its Q3 earnings. Here is a breakdown of the information Scholar Rock Holding presented to its investo...

Scholar Rock Advances with Promising SMA Trial Results

Scholar Rock Holding (SRRK – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst yesterday. Analyst Etzer Darou...

Scholar Rock Holdings: Promising Developments and Strategic Trials Support Buy Rating

Shares of Scholar Rock (SRRK) are up $9.02, or 30%, to $38.94 in morning trading after rival Biohaven (BHVN) reported that taldefgrobep alpha showe...

Scholar Rock up after Biohaven SMA data disappoints

Wedbush raised the firm's price target on Scholar Rock (SRRK) to $47 from $40 and keeps an Outperform rating on the shares. Biohaven's (BHVN) trial...

Scholar Rock price target raised to $47 from $40 at Wedbush

Jefferies analyst Michael Yee reiterated a Buy rating on Scholar Rock Holding (SRRK – Research Report) today and set a price target of $50.00. Mich...

Scholar Rock Holding: Strategic Positioning and Pipeline Progress Justify Buy Rating Amid Reduced Competition

Truist Financial analyst Srikripa Devarakonda maintained a Buy rating on Scholar Rock Holding (SRRK – Research Report) today and set a price target...

Truist Financial Reaffirms Their Buy Rating on Scholar Rock Holding (SRRK)

Truist raised the firm's price target on Scholar Rock (SRRK) to $45 from $36 and keeps a Buy rating on the shares after Biohaven's (BHVN) Phase 3 s...

Truist ups Scholar Rock targets, calls potential takeout target

Jefferies analyst Michael Yee notes that Biohaven's (BHVN) Phase 3 study of taldefgrobep alfa failed on the primary endpoint with no statistical se...

Scholar Rock 'easier to own' after Biohaven data, says Jefferies

JPMorgan was "not surprised" that Biohaven's (BHVN) Phase 3 RESILIENT study for taldefgrobep alfa missed on the primary endpoint of change from bas...

Biohaven outcome 'fundamental net positive' for Scholar Rock, says JPMorgan

Get caught up quickly on the top news and calls moving stocks with these five Top Five lists. 1. STOCK NEWS: Macy's (M) delayed its Q3 earnings rel...

Comments

Scholar Rock Holding

Actualités

Dernières nouvelles pour Scholar Rock Holding (NASDAQ:SRRK) Stock

Les gens regardent aussi

Notizie

PARTENAIRE / CONTRIBUTEUR

BENZINGA MONDIAL