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Cassava Sciences (NASDAQ:SAVA) Stock, Chaîne d'Options

CASSAVA SCIENCES INC

Cassava Sciences

Cassava Sciences Inc is a clinical-stage biotechnology company engaged in developing a scientific approach for the treatment and detection of Alzheimer's disease. Its therapeutic product candidate is called simufilam, and it is a novel treatment for Alzheimer's disease; and investigational diagnostic product candidate is called SavaDx and it is a novel way to detect the presence of Alzheimer's disease from a small sample of blood, possibly years before the overt appearance of clinical symptoms. It is currently conducting two randomized placebo-controlled Phase 3 clinical trials of oral simufilam in patients with Alzheimer's disease dementia. It has one business segment: the development of novel drugs and diagnostics.

Cassava Sciences Inc

Cassava Sciences Inc Warrants (15/11/2024)

SAVANNAH GOLDFIELDS LTD by SAVANNAH GOLDFIELDS LTD

SAVANNAH ENERGY PLC by Savannah Energy Plc

Savannah Energy PLC

SAVANNAH RESOURCES PLC by SAVANNAH RESOURCES PLC

Savannah Resources PLC

Savara Inc

Savaria Corp

Wells Fargo analyst Michael Turrin downgrades Dayforce (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DAY#NYSE">DAY</a>) from Equal-Weight to Underweight and lowers the price target from $60 to $50.

News

Downgrades

Price Target

Analyst Ratings

Wells Fargo Downgrades Dayforce to Underweight, Lowers Price Target to $50

HC Wainwright &amp; Co. analyst Scott Buck reiterates Rezolve AI (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RZLV#NASDAQ">RZLV</a>) with a Buy and maintains $4 price target.

Reiteration

RZLV

HC Wainwright & Co. Reiterates Buy on Rezolve AI, Maintains $4 Price Target

Wells Fargo analyst Andrew Nowinski upgrades Zscaler (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZS#NASDAQ">ZS</a>) from Equal-Weight to Overweight and raises the price target from $260 to $385.

Upgrades

Wells Fargo Upgrades Zscaler to Overweight, Raises Price Target to $385

WIIM

NCLH

Shares of cruise stocks are trading lower following Israel's strikes on Iran, which have raised fuel prices and could cloud travel demand outlook.

UBS analyst Avinatan Jaroslawicz initiates coverage on EMCOR Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EME#NYSE">EME</a>) with a Buy rating and announces Price Target of $570.

Initiation

UBS Initiates Coverage On EMCOR Group with Buy Rating, Announces Price Target of $570

President Donald Trump&#8216;s administration will extend existing 50% steel tariffs to imported home appliances, including refrigerators, dishwashers, washing machines, and cooking ranges, beginning June 23.
What Happened: The Commerce Department announced Thursday that the expanded tariffs will cover eight major appliance categories: combined refrigerator-freezers, small and large dryers, washing machines, dishwashers, chest and upright freezers, cooking stoves and ranges, food waste disposals, and welded wire racks, reported Reuters.
According to the Federal Register posting, tariffs will be &#8220;assessed on these derivative products for the value of the steel content in each product.&#8221;
This marks the second expansion of Trump&#8217;s steel tariff program since March, when the administration initially raised import duties from 25% to 50% on steel and aluminum. The first expansion in March added nearly 300 product categories ranging from horseshoes to bulldozer blades.
Trump <a href="https://www.benzinga.com/news/topics/25/05/45708977/trump-doubles-steel-tariffs-to-50-saying-it-will-secure-american-jobs-backs-us-steels-takeover-by-japans-nippon">doubled steel tariffs</a> to 50% on May 31, calling it a &#8220;major announcement&#8221; to protect American jobs. Speaking at a U.S. Steel facility in Pennsylvania, Trump said he initially considered 40% but raised it after industry feedback. &#8220;At 25% they can sorta get over that fence,&#8221; Trump stated. &#8220;At 50% nobody&#8217;s getting over that fence.&#8221;
See Also: <a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/45921146/shopify-teams-up-with-coinbase-stripe-to-roll-out-usdc-stablecoin-payments-for-merchants">Shopify Teams Up With Coinbase, Stripe To Roll Out USDC Stablecoin Payments For Merchants</a>
Why It Matters: The appliance expansion creates new cost pressures for manufacturers and consumers already facing elevated steel prices. Industry analysts warn the tariffs could add substantial costs to production.
Bloomberg&#8217;s Matthew Miller noted that steel represents approximately 2,800 pounds per vehicle, translating to &#8220;almost <a href="https://www.benzinga.com/markets/tech/25/06/45786145/trumps-50-steel-tariff-could-drive-up-the-costs-for-automakers-almost-2000-of-cost-for-each-car">$2,000 of cost for each car&#8221;</a> as hot-rolled steel approaches $1,000 per ton.
Ford Motor Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/F#NYSE">F</a>) <a href="https://www.benzinga.com/markets/equities/25/06/45841311/trumps-steel-tariffs-hits-straight-on-fords-core-analyst-sees-higher-input-costs-and-eroding-pricing-power-for-tesla-rival">faces particular exposure</a> due to its U.S.-centric manufacturing model. Alex Tsepaev, chief strategy officer at B2PRIME Group, told Benzinga that &#8220;A 50% tariff could inflate COGS significantly just as pricing power erodes in both EV and ICE segments.&#8221; Ford suspended financial guidance in Q1 amid tariff uncertainty following a 65% profit decline.
<div class="wp-block-group is-layout-constrained wp-block-group-is-layout-constrained">
The 2018 Trump-era steel tariffs provide historical context. While U.S. steel production rose slightly, a 2023 International Trade Commission report found the tariffs reduced output in vehicle, machinery, and tool sectors by over $3 billion by 2021, suggesting a net negative economic impact. The U.S. imported $31.3 billion in iron and steel last year, with Canada supplying $7.6 billion worth of materials. The expanded tariffs take effect as domestic steel prices have already climbed due to reduced foreign competition since March. Read Next:
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<li><a href="https://www.benzinga.com/markets/tech/25/06/45921026/chinese-antitrust-regulator-delays-35-billion-us-chip-merger-amid-trade-tensions-report">Chinese Antitrust Regulator Delays $35 Billion US Chip Merger Amid Trade Tensions: Report</a> </li>
</ul>
</div>
Photo courtesy: Joey Sussman / Shutterstock.com

Politics

Trump Extends 50% Steel Tariffs To Home Appliances Like Fridges, Dishwashers Starting June 23

CRTO

Criteo Expands Global Partnership With Dentsu To Power Full-Stack Commerce Media Campaigns

BCRX

BioCryst Pharmaceuticals Announced That National Institute Of Drug And Food Surveillance In Colombia Has Granted Approval For Oral, Once-daily ORLADEYO (berotralstat) For Prophylaxis Of Hereditary Angioedema Attacks In Adults And Pediatric Patients 12 Years Or Older

Citigroup analyst Patrick Cunningham downgrades Sherwin-Williams (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SHW#NYSE">SHW</a>) from Buy to Neutral and lowers the price target from $405 to $385.

Citigroup Downgrades Sherwin-Williams to Neutral, Lowers Price Target to $385

BEAM

Beam Therapeutics Announces New Data From BEACON Phase 1/2 Clinical Trial Of BEAM-101 Supporting Differentiated Profile In Sickle Cell Disease At European Hematology Association 2025 Congress; Company Says Enrollment Complete In Both Adult And Adolescent Cohorts Of BEACON Trial, With 30 Patients Expected To Be Dosed By Mid-2025

Fractyl Health, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GUTS#NASDAQ">GUTS</a>) (the Company), a metabolic therapeutics company focused on pattern-breaking approaches to treat the root causes of obesity and type 2 diabetes (T2D), today announced it will present a poster of new preclinical data from its Rejuva Smart GLP-1 pancreatic gene therapy platform at the American Diabetes Association's (ADA) 85th Scientific Sessions being held June 20-23, 2025, in Chicago, Illinois.
Poster Presentation Details
Session Title: Late Breaking Poster Session Abstract Title: Single-Dose GLP-1–Based Pancreatic Gene Therapy Prevents Obesity and Diabetes in High-Fat–Fed Mice Poster Number: 1970-LB Date and Time: Sunday, June 22, 2025, 12:30 p.m. – 1:30 p.m. Location: Poster Hall (Hall F1, Level 3)

GUTS

Fractyl Health To Present Poster Of New Preclinical Data From Rejuva Smart GLP-1 Pancreatic Gene Therapy Platform At ADA 85th Scientific Sessions

MoneyHero (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MNY#NASDAQ">MNY</a>) reported quarterly losses of $(0.10) per share. This is a 66.67 percent increase over losses of $(0.30) per share from the same period last year. The company reported $14.31 million in sales this quarter. This is a 35.45 percent decrease over sales of $22.18 million the same period last year.

Earnings

MoneyHero Q1 EPS $(0.10) Up From $(0.30) YoY, Sales $14.31M Down From $22.18M YoY

JP Morgan analyst Andrea Teixeira upgrades Newell Brands (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NWL#NASDAQ">NWL</a>) from Neutral to Overweight and raises the price target from $6 to $7.

JP Morgan Upgrades Newell Brands to Overweight, Raises Price Target to $7

– ARV-393 demonstrated significant single-agent activity in models of nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (also known as AITL) and transformed follicular lymphoma –
– In combination with small molecule inhibitors, ARV-393 demonstrated enhanced tumor growth inhibition, including tumor regressions, in models of aggressive diffuse large B-cell lymphoma (DLBCL) –
NEW HAVEN, Conn., June 13, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ARVN#NASDAQ">ARVN</a>), a clinical-stage biotechnology company working to develop a new class of drugs based on targeted protein degradation, today presented data from preclinical studies of ARV-393, the company's investigational PROteolysis TArgeting Chimera (PROTAC) B-cell lymphoma 6 protein (BCL6) degrader. BCL6 is a transcriptional repressor protein and a known driver of B-cell lymphomas. ARV-393 demonstrated significant single-agent activity in a patient derived xenograft (PDX) model of nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (nTFHL-AI also known as AITL) and PDX models of transformed follicular lymphoma (tFL). In combination with oral small molecule inhibitors (SMIs), ARV-393 demonstrated enhanced antitumor activity, including tumor regressions, in cell line-derived xenograft (CDX) models of high-grade B-cell lymphoma (HGBCL) and aggressive diffuse large B-cell lymphoma (DLBCL). The results from these preclinical studies were shared at the European Hematology Association (EHA) 2025 Congress in Milan, Italy.
Key findings from the preclinical studies included:
<ul>
<li>Single-agent ARV-393 significantly reduced tumor burden in peripheral blood, bone marrow and spleen in a systemic PDX model of nTFHL-AI derived from a patient who relapsed post chemotherapy. This is potentially the first preclinical evidence of anti-tumor activity with an efficacious BCL6-targeted small-molecule degrader in a human nTFHL-AI model.</li>
<li>ARV-393 monotherapy treatment resulted in robust (≥95%) tumor growth inhibition (TGI) in two PDX models of tFL.</li>
<li>ARV-393 in combination with 5 classes of SMIs targeting potentially cooperative oncogenic drivers (tazemetostat, palbociclib, everolimus, acalabrutinib, or venetoclax) demonstrated increased TGI in CDX models of HGBCL and aggressive DLBCL compared with the respective monotherapy treatments. Tumor regressions were observed when ARV-393 was combined with tazemetostat, palbociclib, acalabrutinib, or venetoclax.</li>
<li>RNA sequencing studies carried out to further characterize downstream mechanism of action suggested that ARV-393 inhibits tumor cell cycle progression and promotes differentiation, driving antitumor activity and broad combinability in preclinical models.</li>
</ul>

ARVN

Arvinas Presents Data From Preclinical Studies Of ARV-393, PROTAC B-Cell Lymphoma 6 Protein Degrader, At EHA 2025 Congress

Zai Lab Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZLAB#NASDAQ">ZLAB</a>, HKEX: 9688))) today announced new data from its preclinical study of ZL-1503, the Company's promising IL-13/IL-31R bispecific antibody, demonstrating its ability to simultaneously suppress the inflammatory and pruritogenic (itch-causing) pathways in atopic dermatitis (AD). The findings, featured during a poster presentation at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025 in Glasgow, Scotland, highlight the potential of ZL-1503 as a novel treatment option for moderate-to-severe AD.
Medications that inhibit IL-4/IL-13 signaling have markedly improved the therapeutic landscape for AD. Certain AD symptoms are mediated by IL-31; however, they are only partially alleviated by IL-4/IL-13 inhibition. As a result, many patients experience slow and modest clinical responses to currently available medications.
ZL-1503 was evaluated in a pilot preclinical study in non-human primates to assess its long-term effects on IL-31-mediated scratching and IL-13-induced signaling (pSTAT6). Key study results presented at the EAACI Congress 2025 include:
<ul>
<li>An intravenous single dose of ZL-1503 (10 mg/kg, iv) completely inhibited IL-13-mediated pSTAT6 and IL-31-induced scratching for at least 76 days in all preclinical subjects.</li>
<li>Two out of three subjects exhibited prolonged IL-13-mediated pSTAT6 inhibition for over 118 days, and one out of three subjects sustained IL-31-induced scratching inhibition for over 133 days.</li>
<li>Pharmacokinetic (PK) analysis of serum samples collected during the study revealed that ZL-1503 exhibited slow clearance, correlating closely pharmacodynamic (PD) responses, demonstrating strong PK/PD relationships in blocking IL-13 and IL-31 pathways in the preclinical model.</li>
<li>ZL-1503 was well tolerated following weekly IV dosing up to 150 mg/kg.</li>
<li>Additionally, in vitro studies showed that binding to one target did not affect ZL-1503's blocking effects on the other target.</li>
</ul>

ZLAB

Zai Lab Unveils New Atopic Dermatitis Drug That Blocks Both Itch and Inflammation for Over 3 Months in Study

Jefferies analyst Andy Barish upgrades Darden Restaurants (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DRI#NYSE">DRI</a>) from Underperform to Hold and raises the price target from $165 to $210.

Jefferies Upgrades Darden Restaurants to Hold, Raises Price Target to $210

-- Q3M Arm Demonstrated 95% Mean Monthly Attack-Rate Reduction --
-- Q6M Arm Demonstrated 86% Mean Monthly Attack-Rate Reduction –
-- Well-Tolerated with a Favorable Safety Profile --
-- All Patients Remain on Navenibart --
-- Long-Term Data are Highly Consistent with Previous Results and Support the Potential Market-Leading Profile of Navenibart, Administered 2 or 4 Times Per Year --
-- Phase 3 ALPHA-ORBIT Trial Underway and Enrolling Patients --
<a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.astriatx.com&amp;esheet=54273873&amp;newsitemid=20250613335891&amp;lan=en-US&amp;anchor=Astria+Therapeutics%2C+Inc.&amp;index=1&amp;md5=cfd69ef5c1086a0f09f9ca618962670e">Astria Therapeutics, Inc.</a> (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATXS#NASDAQ">ATXS</a>), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunologic diseases, today announced positive initial results from the target enrollment group in the ongoing ALPHA-SOLAR long-term open-label trial evaluating navenibart (STAR-0215), a monoclonal antibody inhibitor of plasma kallikrein, in hereditary angioedema (HAE) patients. These results demonstrated robust overall reduction in the monthly attack rate (92% mean and 97% median). These results further support navenibart's favorable safety and tolerability profile, and potential every three- (Q3M) and every six-month (Q6M) dosing regimens.

ATXS

Astria Therapeutics Reports Initial Results From Target Enrollment Group In Ongoing ALPHA-SOLAR Long-Term Open-Label Trial Evaluating Navenibart In HAE Patients

Citizens Financial Expands Share Buyback Authorization To $1.5B, Company Cites Confidence In Growth Outlook

Jefferies analyst Roger Song downgrades CureVac (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CVAC#NASDAQ">CVAC</a>) from Buy to Hold and lowers the price target from $7 to $5.

CVAC

Jefferies Downgrades CureVac to Hold, Lowers Price Target to $5

The 2025 Global Gender Gap Index, released by the World Economic Forum, shows that gender parity worldwide is still a distant fantasy, with 68.8% of the gap closed across 148 economies, an improvement of only 0.3 percentage points from last year.
What Happened: At the current pace, the report says, it will take 123 years to achieve full global gender parity.
Iceland continues to lead with a 92.6% score, holding the top spot for 16 years and remaining the only country above the 90% mark. The top 10 economies, which have achieved 80% parity, are dominated by European nations, including Finland, Norway, Sweden, Germany and Ireland.
The Health and Survival (96.2%) and Educational Attainment (95.1%) gaps are nearly closed. However, Economic Participation (61%) and Political Empowerment (22.9%) still lag far behind.
Political Empowerment has seen the most long-term improvement, increasing by 9 percentage points since 2006, but full parity is still 162 years away. Economic Participation has improved by 5.6 points in the same period, with 135 years to go at the current rate.
Regionally, Northern America leads in 2025 with 75.8% overall parity and ranks first in economic participation. However, its economic gender gap has barely improved since 2006.
See Also: <a href="https://www.benzinga.com/news/topics/25/06/45858225/track-star-shacarri-richardson-partners-with-reddit-co-founder-alexis-ohanian-to-build-multicity-athlos-track-empire">Track Star Sha&#8217;Carri Richardson Partners With Reddit Co-Founder Alexis Ohanian To Build Multicity Athlos Track Empire</a>
Why It Matters: Closing the gender gap is projected to add up to $7 trillion to the global economy, UN Women estimates.
According to an OECD paper on gender equality and economic growth, "closing labour force participation gaps could add 0.10 p.p. of additional economic growth per year, culminating in a 3.9% boost to GDP per capita by 2060."
This WEF report, released every year, measures access and opportunities essential for reaching full economic potential. It offers a benchmark to inform policy decisions and business strategies.
Speaking <a href="https://www.livemint.com/news/indias-gender-gap-widens-as-it-drops-to-131st-spot-in-global-gender-gap-index-2025-11749710477982.html">to</a> the Press Trust of India, Saadia Zahidi, Managing Director, World Economic Forum, said: "At a time of heightened global economic uncertainty and a low growth outlook combined with technological and demographic change, advancing gender parity represents a key force for economic renewal."
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/markets/macro-economic-events/25/06/45920453/trumps-student-loan-policies-could-inflict-massive-economic-harm-for-americans-warns-expert-instead-of-helping-the-5-million-borrowers">Trump&#8217;s Student Loan Policies Could Inflict &#8216;Massive Economic Harm,&#8217; For Americans, Warns Expert: &#8216;Instead Of Helping The 5 million Borrowers&#8230;&#8217;</a></li>
</ul>
Photo courtesy: Drop of Light / Shutterstock.com

World Economic Forum Says Gender Equality Is 123 Years Away: UN Projects $7 Trillion Boost To Global Economy If Gap Closes

Press Releases

SAVA DEADLINE TOMORROW: ROSEN, A LEADING LAW FIRM, Encourages Cassava Sciences, Inc. Investors with Losses in Excess of $100K to Secure Counsel Before Important February 10 Deadline in Securities Class Action – SAVA

Cassava Sciences, Inc. Securities Fraud Class Action Lawsuit Pending: Contact The Gross Law Firm Before February 10, 2025 to Discuss Your Rights - SAVA

Legal

Cassava Sciences, Inc. Sued for Securities Law Violations – Investors Should Contact Levi & Korsinsky for More Information – SAVA

SAVA Deadline Today: SAVA Investors Have Opportunity to Lead Cassava Sciences, Inc. Securities Fraud Lawsuit

Cassava Sciences Licenses Simufilam Method of Treatment Patent

Cassava Sciences Reports 2024 Financial Results and Provides Business Update

Health Care

General

Cassava Sciences Reports Topline Phase 3 REFOCUS-ALZ Data

Management

Cassava Announces Retirement of Chief Medical Officer, Dr. Jim Kupiec, and Appointment of Dr. Jack Moore as Senior Vice President, Clinical Development

Comments

Cassava Sciences

Cassava Sciences (SAVA) Options

Cassava Sciences (NASDAQ:SAVA) Stock, Chaîne d'Options

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PARTENAIRE / CONTRIBUTEUR

BENZINGA MONDIAL