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Regulus Therapeutics (NASDAQ:RGLS) Stock, Chaîne d'Options

Regulus Therapeutics

Regulus Therapeutics Inc is a biotechnology company focused on the development of microRNA therapies. MicroRNA therapies target diseases such as cancer, metabolic diseases, fibrosis, and inflammatory diseases. The product candidate of the company is RGLS8429, an anti-miR next-generation oligonucleotide targeting miR-17 for the treatment of autosomal dominant polycystic kidney disease (ADPKD), and is in Phase 1b clinical development.

Regulus Therapeutics Inc

REGULUS RES INC by Regulus Resources, Inc.

Regulus Resources Inc

Wells Fargo analyst Yanan Zhu upgrades Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) from Equal-Weight to Overweight and raises the price target from $3 to $6.

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RGLS

Wells Fargo Upgrades Regulus Therapeutics to Overweight, Raises Price Target to $6

<h3>Gainers</h3>
<ul>
<li>23andMe Holding (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ME#NASDAQ">ME</a>) stock increased by 79.1% to $0.95 during Thursday's regular session. The market value of their outstanding shares is at $25.4 million. </li>
<li>Nkarta (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NKTX#NASDAQ">NKTX</a>) stock increased by 55.41% to $2.13. The company's market cap stands at $150.2 million. As per the news, the Q4 earnings report came out yesterday. </li>
<li>Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) stock moved upwards by 53.87% to $1.99. The market value of their outstanding shares is at $131.4 million. </li>
<li>Soleno Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SLNO#NASDAQ">SLNO</a>) shares increased by 43.33% to $70.19. The company's market cap stands at $3.0 billion. </li>
<li>CervoMed (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRVO#NASDAQ">CRVO</a>) stock rose 29.05% to $9.95. The market value of their outstanding shares is at $86.5 million. </li>
<li>Tenon Medical (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TNON#NASDAQ">TNON</a>) shares rose 21.52% to $2.94. The company's market cap stands at $9.2 million. </li>
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<h3>Losers</h3>
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<li>AquaBounty Techs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AQB#NASDAQ">AQB</a>) shares declined by 29.7% to $0.72 during Thursday's regular session. The market value of their outstanding shares is at $2.7 million. </li>
<li>Equillium (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EQ#NASDAQ">EQ</a>) shares declined by 26.14% to $0.56. The market value of their outstanding shares is at $19.8 million. </li>
<li>OSR Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OSRH#NASDAQ">OSRH</a>) shares declined by 23.49% to $2.9. The company's market cap stands at $55.9 million. </li>
<li>EXoZymes (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EXOZ#NASDAQ">EXOZ</a>) shares decreased by 16.82% to $10.49. The company's market cap stands at $99.9 million. </li>
<li>Petros Pharma (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PTPI#NASDAQ">PTPI</a>) stock decreased by 16.52% to $0.11. The market value of their outstanding shares is at $2.8 million. </li>
<li>Longevity Health Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XAGE#NASDAQ">XAGE</a>) shares fell 16.18% to $0.14. The company's market cap stands at $4.2 million. 
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</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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Regulus Therapeutics Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) released topline results from all patients in the fourth cohort in its Phase&nbsp;1b&nbsp;MAD study of farabursen (RGLS8429) autosomal dominant polycystic kidney disease <a target="_blank" href="https://www.benzinga.com/general/health-care" rel="noreferrer noopener">(ADPKD) on Thursday</a>.
In the fourth cohort, 26 subjects received a fixed dose of 300 mg of farabursen every other <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/n44510746/regulus-therapeutics-announces-successful-completion-of-its-phase-1b-multiple-ascending-dose-mad-c" rel="noreferrer noopener">week for three months</a>.
ADPKD is caused by mutations in the PKD1 or PKD2 genes, resulting in end-stage renal disease.
The disease is characterized by the development of multiple fluid-filled cysts, primarily in the kidneys.
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/24/03/37613775/why-is-kidney-disease-focused-regulus-therapeutics-stock-trading-higher-on-tuesday" rel="noreferrer noopener">Why Is Kidney Disease-Focused Regulus Therapeutics Stock Trading Higher On Tuesday?</a>
The full cohort of 26 patients demonstrated a similar mechanistic response based on urinary PC1 and PC2 levels (which inversely correlate with disease severity) and mean halting of htTKV (which inversely correlates with kidney function) growth over the four-month study period.
Cohort 4 data highlights:
<ul>
<li>Increases in urinary PC1 and PC2 levels were similar to cohort 3 and reached a similar level of statistical significance compared to placebo (PC1 p=0.026; PC2 p=0.014).</li>
<li>The mean htTKV growth rate over 4 months was 0.05%, while placebo subjects in the trial experienced a mean growth rate of 2.58%.</li>
<li>Changes in htTKV were highly correlated with changes in renal cyst volume, suggesting farabursen directly impacts disease progression by limiting abnormal cyst growth.</li>
</ul>
An exploratory analysis compared the combination of patients treated with 3 mg/kg or 300 mg fixed dose faburden (n=35) to a combined historical control group of placebo-treated patients from prior pivotal ADPKD trials (n=550).
Farabursen-treated patients experienced a mean reduction in htTKV growth rate (-0.14%) compared to a mean increase of (+1.87%) in placebo-treated patients (p=0.0056).
Farabursen at 300 mg demonstrated a favorable safety and tolerability profile in this study, consistent with earlier cohorts.
RGLS Price Action: Regulus Therapeutics stock is up 51.94% at $1.96 at publication Thursday.
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</ul>
Photo: Shutterstock

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Regulus Therapeutics Stock Shoots Higher After Positive Results From Investigational Drug For Rare Type Of Kidney Disease

WIIM

Regulus Therapeutics shares are trading higher after the company announced topline results from the phase 1b MAD study of Farabursen for autosomal dominant polycystic kidney disease.

<h3>Gainers</h3>
<ul>
<li>Soleno Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SLNO#NASDAQ">SLNO</a>) shares increased by 38.8% to $67.98 during Thursday's pre-market session. The company's market cap stands at $2.9 billion. </li>
<li>Ocean Biomedical (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OCEA#NASDAQ">OCEA</a>) shares moved upwards by 23.05% to $0.1. The market value of their outstanding shares is at $14.4 million. </li>
<li>Edap TMS (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EDAP#NASDAQ">EDAP</a>) shares increased by 20.48% to $2.47. The market value of their outstanding shares is at $91.6 million. As per the press release, Q4 earnings came out today. </li>
<li>XTL Biopharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XTLB#NASDAQ">XTLB</a>) shares moved upwards by 16.36% to $1.28. The company's market cap stands at $6.9 million. </li>
<li>Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) stock rose 16.27% to $1.5. The market value of their outstanding shares is at $99.3 million. </li>
<li>Onconetix (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ONCO#NASDAQ">ONCO</a>) stock rose 15.94% to $0.12. The company's market cap stands at $1.7 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>OSR Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OSRH#NASDAQ">OSRH</a>) stock decreased by 21.9% to $2.96 during Thursday's pre-market session. The market value of their outstanding shares is at $57.0 million. </li>
<li>Equillium (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EQ#NASDAQ">EQ</a>) shares declined by 20.85% to $0.6. The market value of their outstanding shares is at $21.2 million. </li>
<li>Petros Pharma (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PTPI#NASDAQ">PTPI</a>) stock fell 11.19% to $0.12. The market value of their outstanding shares is at $3.0 million. </li>
<li>HeartSciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HSCS#NASDAQ">HSCS</a>) shares fell 10.09% to $2.62. The market value of their outstanding shares is at $2.8 million. </li>
<li>Leap Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LPTX#NASDAQ">LPTX</a>) shares declined by 10.04% to $0.41. The company's market cap stands at $15.6 million. The company's, Q4 earnings came out yesterday. </li>
<li>Anebulo Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ANEB#NASDAQ">ANEB</a>) stock decreased by 8.39% to $1.42. The company's market cap stands at $58.3 million. 
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</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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12 Health Care Stocks Moving In Thursday's Pre-Market Session

<ul>
<li>Consistent demonstration of&nbsp;polycystin (PC) biomarker impact confirming 300 mg fixed dose selection to achieve optimal kidney exposure</li>
<li>Patients receiving 300 mg&nbsp;farabursen demonstrated a mean halting of height-adjusted total kidney volume (htTKV) growth over 4 months</li>
<li>Exploratory analysis of patients from high-dose cohorts demonstrates statistical significance in&nbsp;htTKV change compared to a large cohort of historical placebo-treated patients, which meaningfully derisks the 12-month htTKV endpoint in the planned Phase 3 trial</li>
<li>Company on track for initiation of Phase 3 single pivotal trial in third quarter 2025</li>
</ul>

Regulus Therapeutics Announced Topline Results From All Patients In The Fourth Cohort In Its Phase 1b MAD Study Of Farabursen For Autosomal Dominant Polycystic Kidney Disease

Canaccord Genuity analyst Whitney Ijem maintains Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy and maintains $28 price target.

Canaccord Genuity Maintains Buy on Regulus Therapeutics, Maintains $28 Price Target

HC Wainwright &amp; Co. analyst Raghuram Selvaraju reiterates Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Buy and maintains $10 price target.

Reiteration

HC Wainwright & Co. Reiterates Buy on Regulus Therapeutics, Maintains $10 Price Target

Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) reported quarterly losses of $(0.20) per share which beat the analyst consensus estimate of $(0.21) by 4.76 percent. This is a 50 percent increase over losses of $(0.40) per share from the same period last year.

Earnings

Earnings Beats

Regulus Therapeutics Q4 2024 GAAP EPS $(0.20) Beats $(0.21) Estimate

Regulus Therapeutics Announced Positive Clinical And Regulatory Updates From Its ADPKD Program, Says  Topline Data From An Interim Analysis Of Fourth Cohort Of Its Phase 1B Multiple-ascending Dose Clinical Trial Showed Continued Mechanistic Dose Response

Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) reported quarterly losses of $(0.21) per share which missed the analyst consensus estimate of $(0.17) by 23.53 percent. This is a 47.5 percent increase over losses of $(0.40) per share from the same period last year.

Earnings Misses

Regulus Therapeutics Q3 EPS $(0.21) Misses $(0.17) Estimate

Regulus Therapeutics Completes Enrollment Of Fourth Cohort In Phase 1b Multiple-Ascending Dose Clinical Trial Of RGLS8429 For Treatment Of Autosomal Dominant Polycystic Kidney Disease With 26 Patients Enrolled

Oppenheimer analyst Andreas Argyrides reiterates Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) with a Outperform and maintains $7 price target.

Oppenheimer Reiterates Outperform on Regulus Therapeutics, Maintains $7 Price Target

Regulus Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RGLS#NASDAQ">RGLS</a>) reported quarterly losses of $(0.17) per share which missed the analyst consensus estimate of $(0.13) by 30.77 percent. This is a 54.05 percent increase over losses of $(0.37) per share from the same period last year.

Regulus Therapeutics Q2 EPS $(0.17) Misses $(0.13) Estimate

Press Releases

Regulus Therapeutics Announces Participation at Two Healthcare Investment Conferences

Regulus Therapeutics Announces Completion of Enrollment in Fourth Cohort of Phase 1b Multiple-Ascending Dose (MAD) Clinical Trial of RGLS8429 for the Treatment of Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Regulus Therapeutics Reports Third Quarter 2024 Financial Results and Recent Updates

Regulus Therapeutics Announces Participation at Upcoming Healthcare Investment Conferences

Regulus Therapeutics Announces Positive Clinical and Regulatory Updates from its Autosomal Dominant Polycystic Kidney Disease (ADPKD) Program for Farabursen (RGLS8429)

Regulus Therapeutics to Present at the Oppenheimer 35th Annual Healthcare Life Sciences Conference

Regulus Therapeutics to Present at the Leerink Partners 2025 Global Healthcare Conference

Regulus Therapeutics Reports Fourth Quarter and Year-End 2024 Financial Results and Recent Updates

Regulus Therapeutics Announces Successful Completion of its Phase 1b Multiple-Ascending Dose (MAD) Clinical Trial of Farabursen (RGLS8429) for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

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