Dernières nouvelles pour Palatin Techs (AMEX:PTN) Stock

PALATIN TECHNOLOGIES INC

Palatin Techs

Palatin Technologies Inc is a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor system. The product candidates are targeted, receptor-specific therapeutics for the treatment of diseases with significant unmet medical need and commercial potential.

Palatin Technologies Inc

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Palatin Technologies Inc.&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PTN#NYSE">PTN</a>) on Monday reported topline data with co-administered melanocortin-4 receptor (MC4R) agonist bremelanotide plus glucagon-like peptide-1/gastric inhibitory polypeptide <a target="_blank" href="https://www.benzinga.com/topic/weight-loss" rel="noreferrer noopener">(GLP-1/GIP) tirzepatide</a>.
Eli Lilly And Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>) tirzepatide is available as Mounjaro and Zepbound for diabetes and weight loss.
Topline data results from the study were highly statistically significant for the study&#8217;s primary endpoint, which was percent weight loss in patients for the co-administration of MC4R agonist bremelanotide plus&nbsp;GLP-1/GLP tirzepatide compared to placebo, over the <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/n44558732/palatin-announces-mc4r-agonist-bremelanotide-co-administered-with-glp-1gip-tirzepatide-meets-prima" rel="noreferrer noopener">8-week treatment period</a>.
<ul>
<li>The co-administered group had a 4.4% reduction in weight compared to 1.6% for the placebo group.</li>
</ul>
Also Read: <a target="_blank" href="https://www.benzinga.com/general/biotech/25/03/44536083/palatin-technologies-touts-positive-results-from-mid-stage-study-for-experimental-drug-for-ulcerative-colitis-halts-patients-enrollment-citing-strategic-focus" rel="noreferrer noopener">Palatin Technologies Touts Positive Results From Mid-Stage Study For Experimental Drug For Ulcerative Colitis, Halts Patients Enrollment Citing Strategic Focus</a>
The primary analysis for additive effect demonstrated that:
<ul>
<li>40% of patients in the co-administered group achieved a 5% reduction in their body weight, compared to 27% for the tirzepatide alone group.</li>
<li>27% of patients in the co-administered group achieved a 6% reduction in their body weight, compared to 13% for the tirzepatide alone group.</li>
<li>19% of patients in the co-administered group achieved a 7% reduction in their body weight, compared to 0% for the tirzepatide alone group.</li>
</ul>
Over 50% of the lost weight was regained within two weeks after treatment cessation in both the co-administration and the tirzepatide-only groups, a common occurrence following the discontinuation of&nbsp;GLP-1/GIP therapy.
The data indicated that weight regain was effectively halted in the MC4R agonist bremelanotide group.
Additionally, co-administration of the MC4R agonist with the&nbsp;GLP-1/GIP therapy showed no increase in safety or tolerability concerns among patients.
Further data analysis is ongoing, including exploratory endpoints such as body composition and body mass index.
Palatin is advancing the development of its next-generation MC4R long-acting peptide and oral small molecule compounds as stand-alone treatments, as well as in combination with&nbsp;GLP-1/GIP (incretin therapy), and as monotherapy for multiple genetic obesity disorders.
Investigational New Drug applications are expected to be submitted in the fourth quarter of calendar 2025, with clinical data expected in the first half of 2026.
Price Action: PTN stock is down 14.6% at $0.5656 at the last check Monday.
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Palatin Technologies' Obesity Drug Co-Administered With Eli Lilly's Blockbuster Drug Shows 4.4% Reduction In Weight

The Company reported topline data with co-administered melanocortin-4 receptor (MC4R) agonist bremelanotide plus glucagon like peptide-1/gastric inhibitory polypeptide (GLP-1/GIP) tirzepatide and highlighted next steps in its obesity program for its novel next-generation MC4R long-acting peptides and oral small molecules.

Palatin Technologies Says BMT-801 Phase 2 Obesity Co-administration Study Met Its Primary Endpoint And Was Highly Statistically Significant

Palatin Technologies Inc.&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PTN#NYSE">PTN</a>) on Friday released topline results from its Phase 2 study of PL8177, a selective melanocortin-1 receptor (MC1R) agonist, in patients with <a href="https://www.benzinga.com/general/health-care" target="_blank" rel="noreferrer noopener">active ulcerative colitis</a>.
The Phase 2 randomized, placebo-controlled study evaluated 12 patients (nine in the PL8177 arm and three in the placebo arm) with active ulcerative colitis for <a href="https://www.benzinga.com/pressreleases/25/03/n44533405/palatin-announces-positive-topline-results-from-phase-2-ulcerative-colitis-uc-study-of-oral-melano" target="_blank" rel="noreferrer noopener">eight weeks of treatment</a>:
<ul>
<li>The company said clinical remission was achieved in 33% (3 of 9) of PL8177-treated patients versus 0% (0 of 3) on placebo.</li>
<li>Clinical response (statistically significant) was demonstrated in 78% (7 of 9) of PL8177-treated patients versus 33% (1 of 3) on placebo.</li>
<li>Symptomatic remission was achieved in 56% (5 of 9) of PL8177-treated patients versus 33% (1 of 3) on placebo.</li>
<li>Results for a subset of patients with more moderate disease at baseline showed that three of five (60%) PL8177-treated patients showed improvement in all three segments.
<ul>
<li>Four of five (80%) PL8177-treated patients showed improvement in two of the three segments.</li>
<li>Zero of one (0%) placebo patients showed improvement in two or more segments.</li>
</ul>
</li>
</ul>
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Treatment with oral PL8177 was well tolerated, and no treatment-related side effects were reported.
The study originally planned to enroll up to 28 patients, with an interim analysis after 12-16 participants. Due to a shift in strategic focus, Palatin stopped enrollment at 12 patients to accelerate out-licensing discussions and redirect resources to developing its melanocortin obesity assets.
As a result of lower patient numbers, the study was not powered to show statistical significance.
On Tuesday, the U.S. Food &amp; Drug Administration granted orphan drug designation to Palatin Technologies&#8217; PL7737, an oral treatment that activates the melanocortin-4 receptor, for leptin receptor deficiency, including obesity <a target="_blank" href="https://www.benzinga.com/pressreleases/25/03/n44470950/palatins-oral-mc4r-agonist-pl7737-receives-fda-orphan-drug-designation-for-obesity-due-to-leptin-r" rel="noreferrer noopener">caused by this condition</a>.
Price Action: PTN stock is down 2.43% at $0.68 during the premarket session at the last check Friday.
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</ul>
Image via Shutterstock

Palatin Technologies Touts Positive Results From Mid-Stage Study For Experimental Drug For Ulcerative Colitis, Halts Patients Enrollment Citing Strategic Focus

<ul>
<li>Clinical Remission: Achieved in 33% of PL8177-treated patients versus 0% on placebo after eight weeks of treatment.</li>
<li>Clinical Response (statistically significant): Demonstrated in 78% of PL8177-treated patients versus 33% on placebo after eight weeks of treatment (p&lt;0.005).</li>
</ul>

Palatin Reports Topline Results From Phase 2 Study Of PL8177; Says Endpoints Align With FDA's Recommended Primary And Key Secondary Endpoints For Evaluating Efficacy In UC Clinical Trials

<h3>Gainers</h3>
<ul>
<li>Tenon Medical (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TNON#NASDAQ">TNON</a>) stock increased by 367.2% to $4.57 during Tuesday's pre-market session. The market value of their outstanding shares is at $14.3 million. The company's, Q4 earnings came out 3 days ago. </li>
<li>Predictive Oncology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/POAI#NASDAQ">POAI</a>) shares rose 104.48% to $2.28. The company's market cap stands at $16.4 million. </li>
<li>Palatin Techs (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/PTN#AMEX">PTN</a>) shares increased by 17.04% to $0.88. The company's market cap stands at $22.9 million. </li>
<li>Alumis (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALMS#NASDAQ">ALMS</a>) stock increased by 16.29% to $4.39. The company's market cap stands at $238.8 million. </li>
<li>Know Labs (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/KNW#AMEX">KNW</a>) stock increased by 14.28% to $1.2. The company's market cap stands at $3.3 million. </li>
<li>BioSig Technologies (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BSGM#NASDAQ">BSGM</a>) shares increased by 10.34% to $0.54. The company's market cap stands at $12.9 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>Mural Oncology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MURA#NASDAQ">MURA</a>) stock declined by 49.6% to $1.93 during Tuesday's pre-market session. The market value of their outstanding shares is at $33.2 million. </li>
<li>Orchestra BioMed Hldgs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OBIO#NASDAQ">OBIO</a>) shares declined by 17.95% to $3.75. The market value of their outstanding shares is at $141.8 million. </li>
<li>Cyclo Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CYTH#NASDAQ">CYTH</a>) stock decreased by 12.77% to $0.62. The company's market cap stands at $20.2 million. </li>
<li>GlucoTrack (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GCTK#NASDAQ">GCTK</a>) stock declined by 10.52% to $0.24. The market value of their outstanding shares is at $3.1 million. </li>
<li>Inspire Veterinary (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IVP#NASDAQ">IVP</a>) shares decreased by 10.39% to $1.64. The market value of their outstanding shares is at $2.4 million. </li>
<li>Capstone Holding (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CAPS#NASDAQ">CAPS</a>) stock declined by 9.75% to $2.5. The company's market cap stands at $3.5 million. 
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</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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The FDA Has Granted Orphan Drug Designation To Palatin Technologies' PL7737, An Oral Treatment That Activates The Melanocortin-4 Receptor, For Leptin Receptor Deficiency, Including Obesity Caused By This Condition

HC Wainwright &amp; Co. analyst Joseph Pantginis maintains Palatin Techs (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/PTN#AMEX">PTN</a>) with a Buy and lowers the price target from $17 to $7.

Price Target

Analyst Ratings

HC Wainwright & Co. Maintains Buy on Palatin Techs, Lowers Price Target to $7

Palatin Techs (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/PTN#AMEX">PTN</a>) reported quarterly losses of $(0.12) per share which beat the analyst consensus estimate of $(0.42) by 71.43 percent. This is a 78.57 percent increase over losses of $(0.56) per share from the same period last year.

Earnings

Earnings Beats

Palatin Techs Q2 2025 GAAP EPS $(0.12) Beats $(0.42) Estimate. Cash And Equivalents Of $3.4M

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Earnings Scheduled For February 13, 2025

HC Wainwright &amp; Co. analyst Joseph Pantginis reiterates Palatin Techs (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/PTN#AMEX">PTN</a>) with a Buy and maintains $17 price target.

Reiteration

HC Wainwright & Co. Reiterates Buy on Palatin Techs, Maintains $17 Price Target

Palatin Technologies, Inc. (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/ptn#NYSE">PTN</a>) ("Palatin" or the "Company"), a biopharmaceutical company developing first-in-class medicines based on molecules that modulate the activity of the melanocortin receptor system, today announced that it has entered into definitive agreements with a single healthcare focused institutional investor for the purchase and sale of 4,688,000 shares of its common stock (or common stock equivalents in lieu thereof) in a registered direct offering (the "Registered Direct Offering") at a purchase price of $1.00 per share.

Penny Stocks

Offerings

Palatin Technologies Announces $4.7M Direct Offering Of 4.688M Shares Of Common Stock At A Price Of $1.00 Each

WIIM

Palatin Technologies shares are trading higher after the company announced the completion of its Phase 2 BMT-801 clinical study of MC4R.

Palatin Technologies Announced The Completion Of Its Phase 2 BMT-801 Clinical Study Of The Co-administration Of MC4R Bremelanotide + GLP-1/GIP Tirzepatide For The Treatment Of Obesity

<h3>Gainers</h3>
<ul>
<li>Silexion Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SLXN#NASDAQ">SLXN</a>) stock increased by 112.1% to $1.23 during Tuesday's pre-market session. The market value of their outstanding shares is at $4.9 million. </li>
<li>IMAC Hldgs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BACK#NASDAQ">BACK</a>) stock increased by 62.84% to $1.35. The company's market cap stands at $2.7 million. </li>
<li>Trinity Biotech (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TRIB#NASDAQ">TRIB</a>) shares rose 61.86% to $1.23. The market value of their outstanding shares is at $33.8 million. </li>
<li>Hepion Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HEPA#NASDAQ">HEPA</a>) stock rose 32.84% to $0.22. The market value of their outstanding shares is at $1.5 million. </li>
<li>Surgery Partners (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SGRY#NASDAQ">SGRY</a>) stock increased by 19.85% to $25.47. The market value of their outstanding shares is at $3.2 billion. </li>
<li>Palatin Techs (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/PTN#AMEX">PTN</a>) shares rose 13.78% to $0.99. The market value of their outstanding shares is at $23.2 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>Sharps Technology (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/STSS#NASDAQ">STSS</a>) stock decreased by 69.2% to $0.45 during Tuesday's pre-market session. </li>
<li>Leap Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LPTX#NASDAQ">LPTX</a>) shares fell 63.54% to $0.82. The market value of their outstanding shares is at $31.4 million. </li>
<li>SAB Biotherapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SABS#NASDAQ">SABS</a>) shares declined by 44.73% to $2.41. The market value of their outstanding shares is at $22.2 million. </li>
<li>Akoya Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AKYA#NASDAQ">AKYA</a>) shares declined by 20.78% to $2.44. The market value of their outstanding shares is at $120.9 million. </li>
<li>Onconetix (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ONCO#NASDAQ">ONCO</a>) shares fell 16.71% to $0.54. The market value of their outstanding shares is at $4.4 million. </li>
<li>Tevogen Bio Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TVGN#NASDAQ">TVGN</a>) shares declined by 12.5% to $1.47. The market value of their outstanding shares is at $257.3 million. 
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</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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<ul>
<li>Open label study designed to evaluate the safety, tolerability, and efficacy of bremelanotide in patients with Type 2 diabetic nephropathy</li>
<li>Demonstrated efficacy at 6 months
<ul>
<li>71% percent of patients achieved a &gt;30% reduction in the urine protein to&nbsp;creatinine ratio (UP/Cr)</li>
<li>71% of patients achieved improved or stabilized estimated&nbsp;glomerular filtration rate (eGFR)</li>
</ul>
</li>
<li>Bremelanotide therapy increased urinary VEGF levels in 37.5% of patients and reduced urinary synaptopodin losses in 36% of patients</li>
</ul>

Palatin Announced Topline Data From BREAKOUT Phase 2b Study Of Bremelanotide In Diabetic Kidney Disease To Assess The Efficacy In Reducing Urinary Protein And Maintaining Podocyte Density And Function

Financing

Palatin Technologies Entered Into A Warrant Exercise Inducement Agreement With An Institutional Investor To Exercise Certain Outstanding Warrants Issued In June 2024 And October 2023 Totaling 3.91M For Gross Proceeds Of Approximately $3.4M

Press Releases

Palatin Provides Update on Anticipated 2025 Corporate Milestones

Palatin Completes Phase 2 Obesity Study With MC4R Bremelanotide Plus GLP-1/GIP Tirzepatide

Palatin Announces $4.7 Million Registered Direct Offering and Concurrent Private Placement

Palatin to Report Second Quarter Fiscal Year 2025 Results; Teleconference and Webcast to be held on February 13, 2025

Palatin Reports Second Quarter Fiscal Year 2025 Financial Results and Provides Business Update

Palatin's Oral MC4R Agonist PL7737 Receives FDA Orphan Drug Designation for Obesity Due to Leptin Receptor Deficiency

Palatin Technologies' Obesity Drug Receives FDA Orphan Designation; Phase 2 Results Imminent (NYSE: PTN)

Palatin Announces Positive Topline Results from Phase 2 Ulcerative Colitis (UC) Study of Oral Melanocortin-1 Receptor Agonist PL8177

Palatin Announces MC4R Agonist Bremelanotide Co-Administered with GLP-1/GIP Tirzepatide Meets Primary Endpoint in Phase 2 Obesity Study

Palatin Technologies' UC Treatment Shows Remarkable 78% Clinical Response Rate in Phase 2 Topline Data – Potential Game-Changer for Millions Suffering from Ulcerative Colitis (NYSE: PTN)

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Palatin Technologies

Tired,Teen,Girl,Rubbing,Dry,Irritable,Eyes,Feel,Eye,Strain

FDA Confirms Acceptability of Palatin&#39;s Remaining Phase 3 Pivotal Clinical Trials For PL9643 In Dry Eye Disease (DED)

Screenshot 2024-08-28 at 6.22.42 PM

Palatin Technologies: Utilizing The Melanocortin System As The Basis For Innovation In Drug Development – Targeting Inflammatory &amp;  Autoimmune Conditions, Obesity And Sexual Dysfunctions

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First Patient Dosed In Phase 2 Clinical Study Of Palatin&#39;s Bremelanotide Co-Administered With Tirzepatide (GLP-1) For The Treatment Of Obesity

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